The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract
Open accessAbstract
Understanding the molecular organisation of intracellular signalling pathways is a topic of considerable research interest. Since many signalling enzymes are widely distributed and have several substrates, a critical component in signal transduction is the control of specificity. This is achieved, in part by the assembly of multiprotein complexes where clusters of signalling enzymes create focal points to disseminate the intracellular action of many hormones. This is particularly true for the cAMP dependent protein kinase (PKA) that is localised throughout the cell via its association with A‐kinase anchoring proteins (AKAPs). Recent data suggest that some AKAPs also interact with phosphodiesterases (PDEs). Compartmentalisation of PDEs not only provides an elegant means to control PKA activation by monitoring the local cAMP flux, but also serves to concentrate and segregate the action of these important regulatory enzymes.
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Citations
Cites
AKAP signalling complexes: focal points in space and time
Wong, W., & Scott, J. D. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1527 · Cited by 1,073
Self-citation
Cited by
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Bathgate, R. A. D., Halls, M. L., van der Westhuizen, E. T., Callander, G. E., Kocan, M., & Summers, R. J. (2013) · Physiological Reviews · doi:10.1152/physrev.00001.2012 · Cited by 534
Regulating gene transcription in response to cyclic AMP elevation
Sands, W. A., & Palmer, T. M. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2007.10.005 · Cited by 326
Houslay, M. D., Baillie, G. S., & Maurice, D. H. (2007) · Circulation Research · doi:10.1161/01.res.0000261934.56938.38 · Cited by 317
Self-citationSubcellular dynamics of protein kinase A activity visualized by FRET-based reporters
Allen, M. D., & Zhang, J. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.07.136 · Cited by 306
Ramos, L. S., Zippin, J. H., Kamenetsky, M., Buck, J., & Levin, L. R. (2008) · The Journal of General Physiology · doi:10.1085/jgp.200810044 · Cited by 118
Metadata
- Authors
- Baillie, G. S., Scott, J. D., & Houslay, M. D.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2005-04-14
- Volume
- 579
- Issue
- 15
- Pages
- 3264-3270
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2018058179
- Cited by
- 209
- References
- 1
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Baillie, G. S., Scott, J. D., & Houslay, M. D. (2005). Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract. FEBS Letters. https://doi.org/10.1016/j.febslet.2005.03.089
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
