The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Expression of macrophage‐selective markers in human and rodent adipocytes
Abstract
CD14, CD68 and/or mouse F4/80 or human epidermal growth factor module‐containing mucin‐like receptor 1 (EMR1) are widely used as macrophage‐specific markers. Since macrophages infiltrate several tissues during inflammatory processes, CD14, CD68 and EMR1‐F4/80 have been employed to discriminate between tissue‐containing macrophages, like adipose tissue (AT), and other cells. Using real‐time PCR experiments, we show that isolated adipocytes from humans and mice AT express high levels of CD14 and CD68 mRNA, whereas EMR1‐F4/80 is mainly present in the macrophage‐containing stroma‐vascular fraction. Furthermore, fibroblasts‐like cells (adipoblasts), preadipocytes and adipocytes from the murine cell lines, 3T3‐F442A and BFC‐1, express CD14 and CD68 mRNA and protein as determined by fluorescence‐activated cell sorter, but not F4/80 which, as expected, is strongly expressed in the macrophage cell line RAW264.7. These results reinforce the view that EMR1‐F4/80 is the best macrophage marker to date and show that CD14 and CD68 are not macrophage‐specific proteins.
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Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature · doi:10.1038/34178 · Cited by 3,525
Obesity-induced inflammatory changes in adipose tissue
Wellen, K. E., & Hotamisligil, G. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200320514 · Cited by 1,823
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Hotamisligil, G. S., & Erbay, E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2449 · Cited by 1,040
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Strissel, K. J., Stancheva, Z., Miyoshi, H., Perfield, J. W., DeFuria, J., Jick, Z., Greenberg, A. S., & Obin, M. S. (2007) · Diabetes · doi:10.2337/db07-0767 · Cited by 1,007
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Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus
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Metadata
- Authors
- Khazen, W., M'Bika, J.-P., Tomkiewicz, C., Benelli, C., Chany, C., Achour, A., & Forest, C.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2005-09-29
- Volume
- 579
- Issue
- 25
- Pages
- 5631-5634
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2046094477
- Cited by
- 167
- References
- 3
- FWCI
- 5.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Khazen, W., M'Bika, J.-P., Tomkiewicz, C., Benelli, C., Chany, C., Achour, A., & Forest, C. (2005). Expression of macrophage‐selective markers in human and rodent adipocytes. FEBS Letters. https://doi.org/10.1016/j.febslet.2005.09.032
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