The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves
Abstract
Botulinum neurotoxins (BoNTs) inhibit neurotransmitter release by selectively cleaving core components of the vesicular fusion machinery. The synaptic vesicle proteins Synaptotagmin‐I and ‐II act as receptors for BoNT/B and BoNT/G. Here we show that BoNT/A also interacts with a synaptic vesicle protein, the synaptic vesicle glycoprotein 2C (SV2C), but not with the homologous proteins SV2A and SV2B. Binding of BoNT/A occurs at the membrane juxtaposed region preceding transmembrane domain 8. A peptide comprising the intravesicular domain between transmembrane domains 7 and 8 specifically reduces the neurotoxicity of BoNT/A at phrenic nerve preparations demonstrating the physiological relevance of this interaction.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
SV2 modulates the size of the readily releasable pool of secretory vesicles
Xu, T., & Bajjalieh, S. M. (2001) · Nature Cell Biology · doi:10.1038/35087000 · Cited by 212
Cited by
Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology
Pirazzini, M., Rossetto, O., Eleopra, R., & Montecucco, C. (2017) · Pharmacological Reviews · doi:10.1124/pr.116.012658 · Cited by 768
Long-Distance Retrograde Effects of Botulinum Neurotoxin A
Antonucci, F., Rossi, C., Gianfranceschi, L., Rossetto, O., & Caleo, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0375-08.2008 · Cited by 450
Botulinum Neurotoxin: A Marvel of Protein Design
Montal, M. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.051908.125345 · Cited by 411
Jankovic, J. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70574-9 · Cited by 332
The updated European Consensus 2009 on the use of Botulinum toxin for children with cerebral palsy
Heinen, F., Desloovere, K., Schroeder, A. S., Berweck, S., Borggraefe, I., van Campenhout, A., Andersen, G. L., Aydin, R., Becher, J. G., Bernert, G., et al. (2010) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2009.09.005 · Cited by 296
Metadata
- Authors
- Mahrhold, S., Rummel, A., Bigalke, H., Davletov, B., & Binz, T.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2006-03-07
- Volume
- 580
- Issue
- 8
- Pages
- 2011-2014
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2170232101
- Cited by
- 315
- References
- 1
- FWCI
- 18.82
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves. https://app.cochat.ai/papers/10.1016/j.febslet.2006.02.074
- The paper
- Mahrhold, S., Rummel, A., Bigalke, H., Davletov, B., & Binz, T. (2006). The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves. FEBS Letters. https://doi.org/10.1016/j.febslet.2006.02.074
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
