FGF21 attenuates lipolysis in human adipocytes – A possible link to improved insulin sensitivity
Abstract
Fibroblast growth factor 21 (FGF21) is active in murine adipocytes and has beneficial metabolic effects in animal models of type 2 diabetes mellitus. We assessed whether FGF21 influences lipolysis in human adipocytes and 3T3‐L1 cells. FGF21 had no short‐time effect (h) while a 3‐day incubation with FGF21 attenuated hormone‐stimulated lipolysis. FGF21 did not influence the mRNA expression of genes involved in regulating lipolysis, but significantly reduced the expression of the lipid droplet‐associated phosphoprotein perilipin without affecting differentiation. Via reduced release of fatty acids into the circulation, the anti‐lipolytic effect could be a mechanism through which FGF21 promotes insulin sensitivity in man.
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Increased insulin sensitization in adipose tissues results in increased glucose uptake in BAT and attenuation of lipolysis in WAT.
“Increased insulin sensitization in adipose tissues results in increased glucose uptake in BAT (11) and attenuation of lipolysis in WAT (5).”
From Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis (2018) · cites this paper as [5]
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References 19 · Cited by 234
- Authors
- Arner, P., Pettersson, A., Mitchell, P. J., Dunbar, J. D., Kharitonenkov, A., & Rydén, M.
- Affiliations
- Karolinska University Hospital (SE)
- Eli Lilly (United States) (US)
- Corresponding author
- Rydén, Mikael
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2008-05-05
- Volume
- 582
- Issue
- 12
- Pages
- 1725-1730
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2011388183
- Cited by
- 234
- References
- 19
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 7 · 2023: 11 · 2022: 11 · 2021: 8 · 2020: 7 · 2019: 14 · 2018: 11 · 2017: 17 · 2016: 16 · 2015: 15 · 2014: 9 · 2013: 11 · 2012: 30
- FWCI
- 7.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- FGF21, lipolysis, human adipocytes, 3T3-L1 cells, insulin sensitivity, type 2 diabetes, perilipin, lipid droplets, fatty acid release, adipogenesis
- MeSH terms
- Perilipin-1, Klotho Proteins, Animals, Carrier Proteins, Cell Differentiation, Fatty Acids, Fibroblast Growth Factors, Glucuronidase, Humans, Insulin Resistance, Lipolysis, Phosphoproteins, Gene Expression, Adipocytes, 3T3-L1 Cells, Mice
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