The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Oxidative demethylation of 3‐methylthymine and 3‐methyluracil in single‐stranded DNA and RNA by mouse and human FTO
Open accessAbstract
The human obesity susceptibility gene, FTO, encodes a protein that is homologous to the DNA repair AlkB protein. The AlkB family proteins utilize iron(II), α‐ketoglutarate (α‐KG) and dioxygen to perform oxidative repair of alkylated nucleobases in DNA and RNA. We demonstrate here the oxidative demethylation of 3‐methylthymine (3‐meT) in single‐stranded DNA (ssDNA) and 3‐methyluracil (3‐meU) in single‐stranded RNA (ssRNA) by recombinant human FTO protein in vitro. Both human and mouse FTO proteins preferentially repair 3‐meT in ssDNA over other base lesions tested. They showed negligible activities against 3‐meT in double‐stranded DNA (dsDNA). In addition, these two proteins can catalyze the demethylation of 3‐meU in ssRNA with a slightly higher efficiency over that of 3‐meT in ssDNA, suggesting that methylated RNAs are the preferred substrates for FTO.
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A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
Scott, L. J., Mohlke, K. L., Bonnycastle, L. L., Willer, C. J., Li, Y., Duren, W. L., Erdos, M. R., Stringham, H. M., Chines, P. S., Jackson, A. U., et al. (2007) · Science · doi:10.1126/science.1142382 · Cited by 2,753
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA
Aas, P. A., Otterlei, M., Falnes, P. Ø., Vågbø, C. B., Skorpen, F., Akbari, M., Sundheim, O., Bjørås, M., Slupphaug, G., Seeberg, E., et al. (2003) · Nature · doi:10.1038/nature01363 · Cited by 638
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Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
Meyer, K. D., Saletore, Y., Zumbo, P., Elemento, O., Mason, C. E., & Jaffrey, S. R. (2012) · Cell · doi:10.1016/j.cell.2012.05.003 · Cited by 4,223
N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
Jia, G., Fu, Y., Zhao, X., Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T., Yang, Y.-G., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.687 · Cited by 4,106
Self-citationReading, writing and erasing mRNA methylation
Zaccara, S., Ries, R. J., & Jaffrey, S. R. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0168-5 · Cited by 2,597
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
Losman, J.-A., & Kaelin, W. G. (2013) · Genes & Development · doi:10.1101/gad.217406.113 · Cited by 570
Fedeles, B. I., Singh, V., Delaney, J. C., Li, D., & Essigmann, J. M. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.656462 · Cited by 416
Metadata
- Authors
- Jia, G., Yang, C.-G., Yang, S., Jian, X., Yi, C., Zhou, Z., & He, C.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2008-09-05
- Volume
- 582
- Issue
- 23-24
- Pages
- 3313-3319
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2093764457
- Cited by
- 423
- References
- 2
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Jia, G., Yang, C.-G., Yang, S., Jian, X., Yi, C., Zhou, Z., & He, C. (2008). Oxidative demethylation of 3‐methylthymine and 3‐methyluracil in single‐stranded DNA and RNA by mouse and human FTO. FEBS Letters. https://doi.org/10.1016/j.febslet.2008.08.019
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