The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
FGF21 N‐ and C‐termini play different roles in receptor interaction and activation
Abstract
MINT‐6799907, MINT‐6799922: FGF21 (uniprotkb: Q9NSA1) binds (MI:0407) to β‐Klotho (uniprotkb: Q86Z14) by surface plasmon resonance (MI:0107)
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In the citing paper
“FGF21 is also subject to proteolytic cleavage by the serine proteases fibroblast activation protein (FAP) and dipeptidyl peptidase IV (DPP-IV)42,43.”
From Metabolic messengers: FGF21 (2021) · cites this paper as [45]
In the citing paper
“FGF21 directly binds to KLB, which then facilitates binding to FGFR1c and then initiates downstream signaling events [[146], [147], [148], [149]].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [147]
In the citing paper
“The deletion of these 10 residues on the C terminus of human FGF21 disrupts its ability to interact with β-klotho and signal to target tissues (89, 144).”
From Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis (2018) · cites this paper as [144]
Citations
Cites
FGF-21 as a novel metabolic regulator
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Klotho converts canonical FGF receptor into a specific receptor for FGF23
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The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21
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βKlotho is required for metabolic activity of fibroblast growth factor 21
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Understanding the Physiology of FGF21
Fisher, F. M., & Maratos-Flier, E. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105339 · Cited by 912
The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic
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Chan, J. C. Y., Piper, D. E., Cao, Q., Liu, D., King, C., Wang, W., Tang, J., Liu, Q., Higbee, J., Xia, Z., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903849106 · Cited by 371
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Self-citationFlippo, K. H., & Potthoff, M. J. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00354-2 · Cited by 311
Metadata
- Authors
- Yie, J., Hecht, R., Patel, J., Stevens, J., Wang, W., Hawkins, N., Steavenson, S., Smith, S., Winters, D., Fisher, S., Cai, L., Belouski, E., Chen, C., Michaels, M. L., Li, Y.-S., Lindberg, R., Wang, M., Véniant, M., & Xu, J.
- Affiliations
- Amgen (United States) (US)
- Corresponding author
- Yie, Junming
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2008-12-04
- Volume
- 583
- Issue
- 1
- Pages
- 19-24
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2076037986
- Cited by
- 149
- References
- 22
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 3 · 2021: 8 · 2020: 10 · 2019: 4 · 2018: 13 · 2017: 13 · 2016: 13 · 2015: 10 · 2014: 12 · 2013: 9 · 2012: 17
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
- Keywords
- FGF21, β-Klotho, receptor binding, partial agonists, co-receptors
- MeSH terms
- Klotho Proteins, Amino Acid Sequence, Cell Line, Fibroblast Growth Factors, Humans, Luciferases, Membrane Proteins, Molecular Sequence Data, Protein Structure, Tertiary, Genes, Reporter, Receptor, Fibroblast Growth Factor, Type 1
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