The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis
Open accessAbstract
The IQGAP family comprises three proteins in humans. The best characterized is IQGAP1, which participates in protein–protein interactions and integrates diverse signaling pathways. IQGAP2 and IQGAP3 harbor all the domains identified in IQGAP1, but their biological roles are poorly defined. Proteins that bind IQGAP1 include Cdc42 and Rac1, E‐cadherin, β‐catenin, calmodulin and components of the mitogen‐activated protein kinase pathway, all of which are involved in cancer. Here, we summarize the biological functions of IQGAPs that may contribute to neoplasia. Additionally, we review published data which implicate IQGAPs in cancer and tumorigenesis. The cumulative evidence suggests IQGAP1 is an oncogene while IQGAP2 may be a tumor suppressor.
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1 retracted
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The many faces of calmodulin in cell proliferation, programmed cell death, autophagy, and cancer
Berchtold, M. W., & Villalobo, A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.10.021 · Cited by 320
Cellular and molecular mechanisms of MT1-MMP-dependent cancer cell invasion.
Castro-Castro, A., Marchesin, V., Monteiro, P., Lodillinsky, C., Rossé, C., & Chavrier, P. (2016) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111315-125227 · Cited by 249
Metadata
- Authors
- White, C. D., Brown, M. D., & Sacks, D. B.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2009-05-09
- Volume
- 583
- Issue
- 12
- Pages
- 1817-1824
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2079078062
- Cited by
- 306
- References
- 88
- FWCI
- 7.80
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
