Additive effects of insulin and muscle contraction on fatty acid transport and fatty acid transporters, FAT/CD36, FABPpm, FATP1, 4 and 6
Abstract
Insulin and muscle contraction increase fatty acid transport into muscle by inducing the translocation of FAT/CD36. We examined (a) whether these effects are additive, and (b) whether other fatty acid transporters (FABPpm, FATP1, FATP4, and FATP6) are also induced to translocate. Insulin and muscle contraction increased glucose transport and plasmalemmal GLUT4 independently and additively (positive control). Palmitate transport was also stimulated independently and additively by insulin and by muscle contraction. Insulin and muscle contraction increased plasmalemmal FAT/CD36, FABPpm, FATP1, and FATP4, but not FATP6. Only FAT/CD36 and FATP1 were stimulated in an additive manner by insulin and by muscle contraction.
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Insulin increases CD36 content in skeletal muscle.
“Further, insulin has been reported to increase CD36 content in skeletal muscle [99].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [99]
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References 39 · Cited by 96
- Authors
- Jain, S. S., Chabowski, A., Snook, L. A., Schwenk, R. W., Glatz, J. F. C., Luiken, J. J. F. P., & Bonen, A.
- Affiliations
- University of Guelph (CA)
- Medical University of Białystok (PL)
- Maastricht University (NL)
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2009-06-13
- Volume
- 583
- Issue
- 13
- Pages
- 2294-2300
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2133197012
- Cited by
- 96
- References
- 39
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 2 · 2020: 6 · 2019: 7 · 2018: 1 · 2017: 4 · 2016: 5 · 2015: 7 · 2014: 7 · 2013: 7 · 2012: 14
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- insulin, muscle contraction, fatty acid uptake, fatty acid transporters, FAT/CD36, FABPpm, FATP1, FATP4, GLUT4, glucose transport, additive effects, skeletal muscle, translocation
- MeSH terms
- Animals, Biological Transport, Hypoglycemic Agents, Insulin, Male, Mice, Inbred C57BL, Muscle Contraction, CD36 Antigens, Aspartate Aminotransferase, Mitochondrial, Fatty Acid-Binding Proteins, Fatty Acid Transport Proteins, Glucose Transporter Type 4, Mice
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