Peptide promiscuity: An evolutionary concept for plant defense
Open accessAbstract
The phenomenon of protein promiscuity, in which multiple functions are associated with a single peptide structure, has gained attention in several research fields, including the plant defense field. With this in mind, this report intends to link various plant defense peptides with common scaffolds (defensins, cyclotides and 2S albumins), and multiple activities with the processes of promiscuity generation and protein evolvability. This link seems to create an efficient system of plant defense against insect pests and pathogens, and is thus essential to plant survival and evolution. This review also identifies future possibilities for the use of peptide promiscuity in designing novel drugs and synthetic biotechnological products.
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Conditions could directly affect multifunctional and promiscuous peptides.
“In summary, it seems that conditions could directly affect multifunctional and promiscuous peptides, as previously suggested by Franco [10]”
From Structural insights into <i>Cn</i>‐AMP1, a short disulfide‐free multifunctional peptide from green coconut water (2015) · cites this paper as [10]
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Meneguetti, B. T., Machado, L. D. S., Oshiro, K. G. N., Nogueira, M. L., Carvalho, C. M. E., & Franco, O. L. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02136 · Cited by 77 · see citing works
Self-citation<i>Cn</i>‐AMP1: A new promiscuous peptide with potential for microbial infections treatment
Silva, O. N., Porto, W. F., Migliolo, L., Mandal, S. M., Gomes, D. G., Holanda, H. H. S., Silva, R. S. P., Dias, S. C., Costa, M. P., Costa, C. R., et al. (2012) · Peptide Science · doi:10.1002/bip.22071 · Cited by 51 · see citing works
Self-citationSantana, M. J., de Oliveira, A. L., Queiroz Júnior, L. H. K., Mandal, S. M., Matos, C. O., de O. Dias, R., Franco, O. L., & Lião, L. M. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.01.029 · Cited by 21 · see citing works
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- Authors
- Franco, O. L.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2011-03-12
- Volume
- 585
- Issue
- 7
- Pages
- 995-1000
- ISSN
- 0014-5793 (ISSN-L)
- OpenAlex
- W2041723515
- Cited by
- 135
- References
- 0
- Citations by year
- 2025: 6 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 10 · 2020: 13 · 2019: 5 · 2018: 8 · 2017: 7 · 2016: 14 · 2015: 11 · 2014: 10 · 2013: 16 · 2012: 13
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- CNPq
- CAPES
- FAPDF
- FAPEMIG
- UCB
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect-Plant Interactions and Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Structural Characterization
- Keywords
- plant defense peptides, defensins, cyclotides, 2S albumin, insect resistance, pathogen resistance, drug design
- MeSH terms
- Animals, Humans, Peptides, Plants, Plant Physiological Phenomena, Evolution, Molecular, Antimicrobial Cationic Peptides, Drug Discovery
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