SIRT5 deacetylates and activates urate oxidase in liver mitochondria of mice
Abstract
Hsp60 , Uox and Sirt5 colocalize by cosedimentation through density gradient (View interaction)
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SIRT5 promotes purine metabolism via urate oxidase.
“and purine metabolism via urate oxidase (Nakamura et al., 2012).”
From SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways (2013) · cites this paper as Nakamura et al., 2012
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References 24 · Cited by 55
- Authors
- Nakamura, Y., Ogura, M., Ogura, K., Tanaka, D., & Inagaki, N.
- Affiliations
- Kyoto University (JP)
- Corresponding author
- Inagaki, Nobuya
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2012-10-16
- Volume
- 586
- Issue
- 23
- Pages
- 4076-4081
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2079709757
- Cited by
- 55
- References
- 24
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 1 · 2019: 2 · 2018: 8 · 2017: 6 · 2016: 7 · 2015: 4 · 2014: 7 · 2013: 4
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (23791026)
- Core Research for Evolutional Science and Technology
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- SIRT5, uricase, protein deacetylation, enzyme activation, liver mitochondria, mitochondrial proteins, acetylation
- MeSH terms
- Acetylation, Animals, Mice, Transgenic, Mitochondria, Liver, Urate Oxidase, Electrophoresis, Gel, Two-Dimensional, Peroxisomes, Sirtuins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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