The Angiomotins – From discovery to function
Open accessAbstract
Angiomotins were originally identified as angiostatin binding proteins and implicated in the regulation of endothelial cell migration. Recent studies have shed light on the role of Angiomotins and other members of the Motin protein family in epithelial cells and in pathways directly linked to the pathogenesis of cancer. In particular, Motins have been shown to play a role in signaling pathways regulated by small G‐proteins and the Hippo–YAP pathway. In this review the role of the Motin protein family in these signaling pathways will be described and open questions will be discussed.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Bag3 regulates Yap and Taz activity by binding to Yap and Taz binding partners such as Lats1, Amotl1 and Amotl2.
“Additionally, Bag3 regulates Yap and Taz activity by binding to Yap and Taz binding partners, such as the Hippo kinase Lats1, Amotl1 and Amotl2 (reviewed in (102)).”
From The Hippo signal transduction network for exercise physiologists (2016) · cites this paper as [102]
The ‘Function: Angiomotin regulation of Hpo/YAP signaling’ section (page unavailable) describes AmotL1, AmotL2 and LATS1/2 as YAP binding partners and discusses angiomotin regulation of YAP/TAZ. It does not establish the claim’s central mechanism—that Bag3 binds LATS1, AmotL1 or AmotL2 to regulate YAP/TAZ—and a search for BAG3 found no relevant passage. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 98 · Cited by 112
Research works printed but not linked: 1
- [86]Zhao B Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes & development 2007 21 2747 61 17974916 PMC2045129
- Authors
- Moleirinho, S., Guerrant, W., & Kissil, J. L.
- Affiliations
- Scripps Research Institute (US)
- Corresponding author
- Kissil, Joseph L.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2014-02-15
- Volume
- 588
- Issue
- 16
- Pages
- 2693-2703
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- PMC
- PMC4112001
- OpenAlex
- W2038411007
- Cited by
- 112
- References
- 98
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 4 · 2022: 7 · 2021: 13 · 2020: 6 · 2019: 11 · 2018: 10 · 2017: 14 · 2016: 14 · 2015: 12 · 2014: 8
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA124495)
- National Institute of Neurological Disorders and Stroke (R01NS077952)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- angiomotin, endothelial cell migration, epithelial cells, small GTPases, Hippo-YAP signaling pathway, carcinogenesis
- MeSH terms
- Angiomotins, Animals, Disease, Gene Expression Regulation, Humans, Membrane Proteins, Microfilament Proteins, Signal Transduction, Neovascularization, Physiologic, Intercellular Signaling Peptides and Proteins, Endothelial Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
