Pregnancy outcome of in vitro fertilization/intracytoplasmic sperm injection with profound teratospermia
Open accessAbstract
Objective To assess the pregnancy outcome of IVF with intracytoplasmic sperm injection (ICSI) in couples with profound teratospermia (Kruger's strict criteria of zero). Design Retrospective analysis of 545 consecutive cycles of IVF/ICSI performed between January 2000 and January 2003. Setting Tertiary care center. Patient(s) Of 545 IVF/ICSI cycles, 45 patients were identified with a semen strict morphology of 0 using Kruger's strict criteria. Intervention(s) Ovarian down-regulation (Lupron) was followed by controlled ovarian stimulation exclusively with hMG. Embryo transfer was performed 2 days after transvaginal aspiration/ICSI. Main outcomes measure(s) Pregnancy outcomes and newborn/infant status. Result(s) Of 45 patients undergoing 54 treatment cycles, 21 patients were positive for pregnancy (38.9% pregnancy/cycle). No birth defects were noted at time of delivery and all infants had obtained appropriate developmental milestones at 1 year of age. Conclusion(s) Men with profound teratospermia (Kruger's strict criteria of zero) may achieve acceptable pregnancy rates after IVF/ICSI thereby alleviating the use of donor sperm in this group. Furthermore, no increased risk of birth defects is apparent in this small series.
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Some investigators have recommended IVF with ICSI in cases of isolated teratozoospermia.
“Indeed, some investigators have recommended IVF with ICSI in cases of isolated teratozoospermia.21”
From Men with a complete absence of normal sperm morphology exhibit high rates of success without assisted reproduction (2017) · cites this paper as [21]
The paper says most centers perform ICSI for severe teratospermia and concludes that IVF/ICSI yielded acceptable pregnancy rates in its small group with 0% normal sperm morphology (Abstract; Discussion). It does not establish a recommendation specifically for isolated teratozoospermia: the Semen Parameters section reports variation in sperm concentration and motility, rather than restricting the group to men whose only abnormal parameter was morphology. (LLM, conf=0.87)
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Research works printed but not linked: 15
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Smith, R., Kovac, J., Cajipe, M., Lamb, D., & Lipshultz, L. (2017) · Asian Journal of Andrology · doi:10.4103/1008-682x.189211 · Cited by 66 · see citing works
Self-citation
- Authors
- McKenzie, L. J., Kovanci, E., Amato, P., Cisneros, P., Lamb, D., & Carson, S. A.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Carson, Sandra A.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2004-10
- Volume
- 82
- Issue
- 4
- Pages
- 847-849
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W1986270351
- Cited by
- 36
- References
- 0
- Citations by year
- 2026: 1 · 2024: 2 · 2022: 2 · 2021: 1 · 2019: 1 · 2017: 3 · 2016: 3 · 2015: 2 · 2013: 1 · 2012: 5
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (NIH P01 HD 36289-01)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Keywords
- in vitro fertilization, intracytoplasmic sperm injection, male infertility, pregnancy rate, congenital malformations, embryo transfer, controlled ovarian stimulation, hMG
- MeSH terms
- Adult, Embryo Transfer, Female, Humans, Infant, Newborn, Infertility, Male, Male, Ovulation Induction, Pregnancy, Pregnancy Outcome, Retrospective Studies, Sperm Motility, Spermatozoa, Sperm Injections, Intracytoplasmic
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