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The Outcome of 150 Babies Following the Treatment With Letrozole or Letrozole and Gonadotropins
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“The potential for teratogenic effects of letrozole has been raised, with an abstract suggesting higher risk of congenital cardiac and bone malformations in newborns. 240”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [240]
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Items 101–200 of 208
Limiting access to letrozole—is it justified?
Tulandi, T., & DeCherney, A. H. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.01.115 · Cited by 14
Costello, M., & Ledger, W. J. (2012) · Women s Health · doi:10.2217/whe.12.14 · Cited by 14
“Also, there are concerns regarding the potential teratogenic effect of letrozole, first raised at an American Society for Reproductive Medicine meeting in 2005 where an oral abstract presentation suggested that the use of letrozole for infertility treatment may be associated with a higher risk of congenital cardiac an…”
BackgroundPoor responders to controlled ovarian hyperstimulation forin vitrofertilisation (IVF)
Kamble, L., Gudi, A., Shah, A. J., & Homburg, R. (2011) · Human Fertility · doi:10.3109/14647273.2011.608241 · Cited by 12
“It is important to be aware that safety concerns about letrozole administration in assisted reproduction, although later found to be completely unsubstantiated, have been raised (Biljan et al., 2005) and so the use of letrozole for this indication is still off-label (see below).”
BackgroundRevisiting ovulation induction in PCOS
Fauser, B. C. J. M. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.156 · Cited by 12
Arya, S., Kupesic-Plavsic, S., Mulla, Z. D., Dwivedi, A. K., Crisp, Z., Jose, J., & Noble, L. S. (2017) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2017.09.023 · Cited by 10
Fertility Preservation Strategies for Breast Cancer Patients
Mastro, L. D., & Venturini, M. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.07.4310 · Cited by 10
How Will the New Global Polycystic Ovary Syndrome Guideline Change Our Clinical Practice?
Jacob, S., & Balen, A. H. (2019) · Clinical Medicine Insights Reproductive Health · doi:10.1177/1179558119849605 · Cited by 9
Is letrozole superior to clomiphene for ovarian stimulation prior to intrauterine insemination?
Khanna, S. C., Kumar, A., Joy, S. G., Tanwar, R., Sharma, S. B., & Prasad, S. (2012) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-012-2579-9 · Cited by 9
Clomiphene Citrate versus Letrozole for Ovarian Stimulation in Therapeutic Donor Sperm Insemination
Hachem, H. E., Antaki, R., Sylvestre, C. V., Kadoch, I.-J., Lapensée, L., & Bouet, P. (2016) · Gynecologic and Obstetric Investigation · doi:10.1159/000452665 · Cited by 8
Préservation de la fertilité dans le cancer du sein : où en est-on en 2014 ?
Comtet, M., Sonigo, C., Valdelièvre, C., Sermondade, N., Sifer, C., & Grynberg, M. (2015) · Bulletin du Cancer · doi:10.1016/j.bulcan.2015.01.008 · Cited by 7
Potential cures for endometriosis
Jacobson, T. Z. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05933.x · Cited by 8
Yun, J., Choi, Y. S., Lee, I., Won, Y. B., Lee, J. H., Seo, S. K., Cho, S., Lee, B. S., & Yun, B. H. (2018) · Reproductive Toxicology · doi:10.1016/j.reprotox.2018.10.006 · Cited by 8
Alizzi, F. J. (2018) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2018.v11i8.25951 · Cited by 8
“Especially, in women with failure or resistance to CC, letrozole was shown to be very effective both in ovulation rate and live birth rate [8].”
BackgroundTakeshima, K., Ezoe, K., Kawasaki, N., Hayashi, H., Kuroda-Kawaguchi, T., & Kato, K. (2022) · F&S Reports · doi:10.1016/j.xfre.2022.03.001 · Cited by 7
“Nonetheless, a previous study reported that the possibility of fetal motor and congenital cardiac abnormalities could increase through letrozole administration (8); hence, letrozole administration was contraindicated in premenopausal women, and the use of letrozole for follicular development was discontinued worldwide…”
BackgroundKahraman, A., & Tülek, F. (2022) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-022-06676-0 · Cited by 7
“However, preliminary reports involving babies conceived via letrozole administration, indicated an increased risk of cardiac and locomotor defects in these infants [15].”
Reassurance of safety of letrozole and suggested approaches in controlled ovarian hyperstimulation
Ata, B., & Tulandi, T. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.03.103 · Cited by 7
Aromatase Inhibitors for Ovarian Stimulation in Patients with Breast Cancer
Ferreiro, E., de Uralde, B. L., Abreu, R., García-Velasco, J. A., & Muñoz, E. (2020) · Current Drug Targets · doi:10.2174/1389450121666200220124607 · Cited by 6
Ganesh, A., Chattopadhyay, R., Babu, K. N., et al. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.04.045 · Cited by 6
Addressing fertility needs of breast cancer patients: oncology perspective
Koczwara, B. (2008) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.8.8.1323 · Cited by 6
Letrozole for ovulation induction
Mitwally, M. F., & Casper, R. F. (2006) · Expert Review of Obstetrics & Gynecology · doi:10.1586/17474108.1.1.15 · Cited by 6
Letrozole in ovulation induction: time to make decisions
Polyzos, N. P., Mauri, D. N., & Tzioras, S. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn050 · Cited by 6
“Preliminary data suggested an increased risk of congenital anomalies in letrozole treated babies (Biljan et al., 2005), whereas recent data from retrospective (Tulandi et al.”
The role of letrozole in in vitro fertilization treatment: new remedy or old mirage?
Bülow, N. S., & Macklon, N. (2024) · Fertility and Sterility · doi:10.1016/j.fertnstert.2024.10.040 · Cited by 5
Zhang, W. Y., Gardner, R. M., Johal, J. K., et al. (2023) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-023-02759-2 · Cited by 5
Konzeptpapier zur Ovarprotektion an deutschen reproduktionsmedizinischen Universitätszentren
Beckmann, M., Binder, H., Dittrich, R., et al. (2006) · Geburtshilfe und Frauenheilkunde · doi:10.1055/s-2006-923974 · Cited by 5
Wang, H., & Zheng, P.-S. (2014) · Gynecologic and Obstetric Investigation · doi:10.1159/000367847 · Cited by 5
Infertility Treatment in Patients with Polycystic Ovary Syndrome (PCOS)
Tomić, V., & Tomić, J. (2012) · Journal of Fertilization In Vitro - IVF-Worldwide Reproductive Medicine Genetics & Stem Cell Biology · doi:10.4172/2165-7491.1000e113 · Cited by 5
“[21] study which reportedan increased risk of cardiac and skeletal abnormalities in infants born after the use of letrozole in ovulation induction.”
BackgroundBegum, P., Shaha, D. R., Hassan, M. K., & Zeba, D. (2021) · Faridpur Medical College Journal · doi:10.3329/fmcj.v15i2.53891 · Cited by 5
Palihawadana, T. S., Wijesinghe, P., & Seneviratne, H. (2015) · Journal of Human Reproductive Sciences · doi:10.4103/0974-1208.158598 · Cited by 5
“[9-11] The initial popularity of letrozole was shadowed by some concerns on its safety profile since the findings of one small study was presented as a conference paper, which reported an increased incidence of fetal anomalies in babies resulting from letrozole induced cycles.[12] However, subsequent studies did not s…”
BackgroundLetrozole at the Crossroads of Efficacy and Fetal Safety in Ovulation Induction: A Narrative Review
Kaltsas, A., Efthimiou, A., Roidos, C., Tzikoulis, V., Georgiou, I. A., Sotiriadis, A., Zachariou, A., Chrisofos, M., Sofikitis, N., & Dimitriadis, F. (2025) · Biomedicines · doi:10.3390/biomedicines13092051 · Cited by 5
“Initial case reports and a non-peer-reviewed study in the mid-2000s raised alarm about possible congenital cardiac defects in letrozole-exposed pregnancies, leading some regulators to temporarily contraindicate letrozole in women of childbearing age [54].”
Rashidi, B. H., Khandzad, B., Shahrokh-Tehraninejad, E., Bagheri, M., & Gorginzadeh, M. (2016) · Europe PMC (PubMed Central) · Cited by 4
Varlı, B., Şükür, Y. E., Özdemir, E. Ü., Özmen, B., Sönmezer, M., Berker, B., Atabekoğlu, C. S., & Aytaç, R. (2024) · Medicina · doi:10.3390/medicina60030407 · Cited by 4
“In an oral presentation by Biljan et al. [34] in 2005, letrozole use was associated with congenital cardiovascular anomalies and locomotor disabilities in offspring, but these findings were never published in a peer-reviewed journal as a research article.”
BackgroundCurrent issues in ovulation induction
Gorthi, S., Balen, A. H., & Tang, T. H. (2012) · The Obstetrician & Gynaecologist · doi:10.1111/j.1744-4667.2012.00117.x · Cited by 4
Etrusco, A., D’Amato, A., Agrifoglio, V., Laganà, A. S., Andrisani, A., Cantatore, C., Caringella, A. M., FRANCISCIS, P. D., & Riemma, G. (2025) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2025.114531 · Cited by 3
Balkrishna, A., Nain, P., Joshi, M., Kumar, B., & Varshney, A. (2022) · Journal of Ovarian Research · doi:10.1186/s13048-022-00982-6 · Cited by 3
“Moreover, neonatal morbidities including gestational diabetes and locomotor malformation have also been reported upon treatment with letrozole and gonadotropins [7].”
BackgroundWang, B., Lin, H., Xia, R.-B., Lin, S., & Li, Z. (2024) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2024.12596 · Cited by 3
“At present, the major concern about application of letrozole as an ovulation‑inducing drug centers on its debatable terato‑ genic effects (6).”
Backgroundvan Santbrink, E. J. P. (2009) · Springer eBooks · doi:10.1007/978-0-387-09718-3_20 · Cited by 3
“A relatively small study group treated with letrozole (n = 150) was compared to a large control group with spontaneous conceptions and suggested increased neonatal risk on bone and cardiac malformations in the former group [ 60 ].”
ResultSamara, N., & Casper, R. F. (2017) · Springer eBooks · doi:10.1007/978-3-319-45534-1_10 · Cited by 5
Ovulasjonsinduksjon ved bruk av letrozol
Ekerhovd, E. (2009) · Tidsskrift for Den norske legeforening · doi:10.4045/tidsskr.08.0129 · Cited by 3
New Advances in Ovulation Induction
Kafy, S. M., & Tulandi, T. (2007) · Postgraduate Obstetrics & Gynecology · doi:10.1097/00256406-200710310-00001 · Cited by 2
The infertility treatment related with polycystic ovary syndrome
Koo, Y. H., & Na, Y. J. (2010) · Korean Journal of Obstetrics & Gynecology · doi:10.5468/kjog.2010.53.10.869 · Cited by 2
Aromatase inhibitors in ovarian stimulation
García-Velasco, J. A. (2006) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)61041-3 · Cited by 2
The use of aromatase inhibitors in infertility and gynecology
Al-Shalati, J., & Tulandi, T. (2011) · Expert Review of Obstetrics & Gynecology · doi:10.1586/eog.11.30 · Cited by 2
Management of Polycystic Ovary Syndrome
Yasmin, E., & Balen, A. H. (2007) · Women s Health · doi:10.2217/17455057.3.3.355 · Cited by 4
Mahtab, N. T., Mahmud, N., & Chowdhury, T. (2019) · BIRDEM Medical Journal · doi:10.3329/birdem.v9i3.43087 · Cited by 2
Fertility preservation in female cancer patients
Lin, K., & Gracia, C. R. (2006) · Expert Review of Obstetrics & Gynecology · doi:10.1586/17474108.1.2.203 · Cited by 2
Abu, H. (2012) · InTech eBooks · doi:10.5772/27856 · Cited by 3
“, 2005 (106) suggested an increased risk of congenital anomalies in letrozole treated babies, whereas recent data from retrospective and prospective trials (107,108) have contested these initial findings and supported the safety of letrozole compared to traditional ovulation induction treatment.”
ResultLetrozole in Fertility Therapy
Marguerie, M., & Bedaiwy, M. A. (2020) · Springer eBooks · doi:10.1007/978-981-15-2377-9_7 · Cited by 3
No 362 - Déclenchement de l'ovulation en présence d'un syndrome des ovaires polykystiques
Smithson, D. S., Vause, T. D. R., & Cheung, A. P. (2018) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/j.jogc.2018.05.013 · Cited by 2
Polycystic Ovary Syndrome: Ovulation Induction Strategies
Taha, L. E., Rizk, B. R., Ledger, W. J., Sayegh, R. A., & Awwad, J. T. (2022) · Cambridge University Press eBooks · doi:10.1017/9781316477021.016 · Cited by 1
Daftary, G. V., Daftary, G. S., Patil, S., Mishra, A. O., & Patil, N. (2026) · Journal of IVF-Worldwide · doi:10.46989/001c.158185 · Cited by 1
Müderris, İ. İ., & Öner, G. (2012) · InTech eBooks · doi:10.5772/25555 · Cited by 1
“Notably, letrozole has warned clinicians against prescribing drugs for ovulation induction on the basis of reports of birth defects and spontaneous miscarriages in its safety database (27).”
BackgroundRuiz, F., & García-Velasco, J. A. (2011) · Expert Review of Obstetrics & Gynecology · doi:10.1586/eog.11.62 · Cited by 1
Microtia After Ovulation Induction with Letrozole
E. (2011) · American Journal of Pharmacology and Toxicology · doi:10.3844/ajptsp.2011.107.108 · Cited by 1
Ovulation induction in the gynecological cancer patient
Wahba, A. H. (2014) · World Journal of Obstetrics and Gynecology · doi:10.5317/wjog.v3.i2.61 · Cited by 1
Mild Stimulation Protocol for Poor Ovarian Responders Undergoing IVF
Revelli, A., Casano, S., & Benedetto, C. (2017) · Springer eBooks · doi:10.1007/978-3-319-53454-1_16 · Cited by 1
Friedman, J. M., & Weber-Schöndorfer, C. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-408078-2.00014-7 · Cited by 1
Current Knowledge on the Use of Letrozole in Ovarian Stimulation
Mangal, S. (2020) · International Journal of Infertility & Fetal Medicine · doi:10.5005/jp-journals-10016-1205 · Cited by 1
Ali, H. A. A. W., Aly, T., & Ragab, A. A. (2022) · Evidence Based Women s Health Journal · doi:10.21608/ebwhj.2021.113640.1164 · Cited by 1
“Letrozole, an aromatase inhibitor, has been reportedly effective in ovulation induction and increasing birth rate especially in CC-resistant patients[8].”
BackgroundWang, X., Li, Y., Zhang, C., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-072021 · Cited by 1
“In addition, considering that HRT may increase the risk of HDP and individual studies have doubts about the safety of letrozole, 13 we will compare the safety of the two endometrial preparation protocols simultaneously (including maternal complications and congenital malformations).”
BackgroundTorrealday, S., & Patrizio, P. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8394-6_12 · Cited by 1
Palihawadana, T. S., Dissanayake, D., Wijesinghe, P. S., et al. (2014) · Sri Lanka Journal of Obstetrics and Gynaecology · doi:10.4038/sljog.v36i3.7715 · Cited by 1
Déclenchement de l'ovulation en présence du syndrome des ovaires polykystiques
Vause, T. D. R., Cheung, A. P., Cheung, A. P., Sierra, S., Claman, P., Graham, J., Guillemin, J.-A., Lapensée, L., Stewart, S., Vause, T. D. R., et al. (2010) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)34505-4 · Cited by 1
The Role of Androgens in Controlled Ovarian Stimulation
Revel, A., & Hyman, J. H. (2015) · Springer eBooks · doi:10.1007/978-81-322-1686-5_15 · Cited by 1
Preservación de la fertilidad femenina
Comtet, M., Bénard, J., & Grynberg, M. (2017) · EMC - Ginecología-Obstetricia · doi:10.1016/s1283-081x(16)82403-0 · Cited by 1
Aromatase inhibitors forfemaleinfertility treatment
Atay, V., Yaralı́, H., Bozdağ, G., Özışık, G., Akin, D., & Muhçu, M. (2007) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.17.2.137 · Cited by 1
“[35] in which ∼ 150 births, which were compared with > 36,000 ones, spontaneously considered.”
Background„Off-label-Anwendung“ von Aromatasehemmern
Bohlmann, M. K., Hornemann, A., Weichert, J., Stichtenoth, G., Ortmann, J., Diedrich, K., & Lüdders, D. (2008) · Gynäkologische Endokrinologie · doi:10.1007/s10304-008-0265-6 · Cited by 1
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Oktay, K., & Lee, S. J. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.07.4633 · Cited by 1
Baker, M. B., & Bendikson, K. A. (2010) · doi:10.1002/9781444323030.ch98
Yapura, M. J. (2013) · HARVEST (University of Saskatchewan) · Cited by 1
Mild forms of ovarian stimulation
Aboulghar, M. A., & Rizk, B. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511762390.004
Jogessar, J. V. (2011) · ResearchSpace (University of KwaZulu-Natal)
Potential use of aromatase inhibitors in gynecology
Lukic, J., & Tulandi, T. (2006) · Expert Review of Obstetrics & Gynecology · doi:10.1586/17474108.1.1.41
Mild strategies for IVF: from theory to practice
Verberg, M. F. G. (2007) · Utrecht University Repository (Utrecht University)
Aromatase Inhibitors: New Drug of Choice for Induction of Ovulation
Siddiqui, M., Mahmud, N., Begum, M., & Chowdhury, T. (1970) · Journal of Bangladesh College of Physicians and Surgeons · doi:10.3329/jbcps.v28i1.4642
Aromatase Inhibitors in Infertility Treatment: Risks and Benefits
Daya, S. (2006) · Women s Health · doi:10.2217/17455057.2.4.501
Siebert, T. I. (2008) · SUNScholar (Stellenbosch University)
Ovarian Stimulation for Poor Responders
Fukuda, A. “. (2015) · Springer eBooks · doi:10.1007/978-81-322-1121-1_9
Aromatase Inhibitors in Clinical Gynecology
Onwubalili, N., & Cho, M. M. (2009) · Postgraduate Obstetrics & Gynecology · doi:10.1097/01.pgo.0000358041.98343.25
Singh, S., Singh, S., & Ashraf, C. M. (2015) · Springer eBooks · doi:10.1007/978-81-322-1686-5_5
Aromatase Inhibitors in the Treatment of Unexplained Female Infertility
Sekhon, L. H., Rekawek, P., & Grunfeld, L. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2140-9_26
Ovulation induction for anovulatory patients
van Santbrink, E. J. P., & Fauser, B. C. J. M. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511762390.005
Treatment options I. Ovulation induction
Oskowitz, S. P. (2011) · Reproductive medicine and assisted reproductive techniques series · doi:10.3109/9781841848181.006
Déclenchement de l'ovulation en présence du syndrome des ovaires polykystiques Résumé
Vause, T. D. R., Cheung, A. P., Sierra, S., Claman, P., Graham, J., Guillemin, J., Lapensée, L., Stewart, S., Wong, B. C.-M., Société, C. D., et al. (2010)
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Hormonal Treatments in the Infertile Women
Dafopoulos, K. C., & Tarlatzis, B. C. (2020) · Endocrinology · doi:10.1007/978-3-030-03594-5_13-1
Androgens for Improving Ovarian Response to Stimulation
Yakın, K. (2020) · Springer eBooks · doi:10.1007/978-981-15-2377-9_50
Anshu, A., Kumari, U., & Jana, D. (2021) · Indian Journal Of Applied Research · doi:10.36106/9712281
Chishti, J., Chowdhary, J., Paliwal, A., Sharma, C., & Choudhary, M. (2021) · Journal of Evolution of Medical and Dental Sciences · doi:10.14260/jemds/2021/408
Kahraman, A., & Tülek, F. (2022) · Research Square · doi:10.21203/rs.3.rs-1267736/v1
Ovulation Induction for Anovulatory Patients
van Santbrink, E. J. P., & Fauser, B. C. J. M. (2022) · Cambridge University Press eBooks · doi:10.1017/9781316477021.005
Torrealday, S., & Patrizio, P. (2022) · Springer eBooks · doi:10.1007/978-3-030-92589-5_15
Treatment options I. Ovulation induction
Oskowitz, S. P. (2011) · CRC Press eBooks · doi:10.3109/9781841848181-12
Faculty Opinions recommendation of Polycystic ovary syndrome throughout a woman's life.
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“hyperandrogenism, or ultrasound-guided detection of PCO morphology according to the Rotterdam criteria (4).”
BackgroundMethodInvestigation of Teratogenic Effects of Letrozole on Fetal Bone Development
Bilir, A., Atay, E., Fırat, F., Ertekin, A., & Bozkurt, E. (2022) · International Journal of Morphology · doi:10.4067/s0717-95022022000401108
“This situation was seriously discussed at the meeting of the American Society for Reproductive Medicine in 2005, and the safety of the fetus in mothers using letrozole was found to be of concern (Biljan et al., 2005).”
BackgroundThe mild stimulation in vitro fertilization protocol
Nargund, G., Datta, A. K., & Fauser, B. C. J. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85687-4.00027-0
A, A. H. A., Aly, T., & Ragab, A. A. (2023) · doi:10.36959/983/638
Begum, M. R., Ehsan, M., Quadir, E., Ehsan, N., Hossain, I., & Sharif, A. B. (2024) · Journal of South Asian Federation of Obstetrics and Gynaecology · doi:10.5005/jp-journals-10006-2476
Metadata
- Authors
- Biljan, M. M., Hemmings, R., & Brassard, N.
- Affiliations
- St Mary's Hospital Centre (CA)
- ORCID
- Hemmings, R.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2005-09
- Volume
- 84
- Pages
- S95
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2115337926
- Cited by
- 206
- References
- 0
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 12 · 2021: 7 · 2020: 8 · 2019: 9 · 2018: 9 · 2017: 8 · 2016: 4 · 2015: 11 · 2014: 10 · 2013: 6 · 2012: 17
- FWCI
- 13.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- letrozole, gonadotropins, ovulation induction, aromatase inhibitors, pregnancy outcomes, infertility treatment, assisted reproduction
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