Plasma adrenomedullin levels in patients with polycystic ovary syndrome
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Objective To evaluate adrenomedullin levels in patients with polycystic ovary syndrome (PCOS). Design Prospective study. Setting Department of obstetrics and gynecology in a university hospital. Patient(s) Thirty-eight women with PCOS and 29 healthy control subjects were enrolled in the study. Intervention(s) Plasma adrenomedullin, serum androstenedione, free T, T, DHEAS, SHBG, thyrotropin, PRL, FSH, LH, and E2 were measured in each subject. Insulin resistance was estimated by fasting insulin level, fasting glucose:insulin ratio and 75-g glucose tolerance test for 2 hours. Main outcome measure(s) Plasma adrenomedullin levels and correlations among adrenomedullin and gonadotropins, female sex steroids, androgens, and insulin resistance. Result(s) There was no significant difference concerning plasma adrenomedullin concentrations between the groups. In patients with PCOS, fasting glucose, fasting insulin, body mass index, and free T were inversely correlated with the plasma adrenomedullin. Plasma adrenomedullin was significantly correlated with glucose:insulin ratio. After controlling for body mass index, there were no significant correlations between the above-mentioned parameters. Conclusion(s) Adrenomedullin may play a role in regulating the insulin metabolism in patients with PCOS.
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Previous cross-sectional studies evaluating MR-proADM, MR-proANP and copeptin in PCOS and healthy controls have produced contradicting results.
“The three biomarkers have previously been evaluated in PCOS and healthy controls in cross-sectional studies, with contradicting results (13, 14, 15, 16, 17, 18).”
From Effect of liraglutide on atrial natriuretic peptide, adrenomedullin, and copeptin in PCOS (2018) · cites this paper as [13]
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Letizia, C., Iacobellis, G., Caliumi, C., Leonetti, F., Cotesta, D., Ribaudo, M., Petramala, L., Cianci, R., Celi, M., D'Erasmo, E., et al. (2005) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2005-837519 · Cited by 11 · see citing works
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Effect of liraglutide on atrial natriuretic peptide, adrenomedullin, and copeptin in PCOS
Frøssing, S., Nylander, M., Kistorp, C., Skouby, S. O., & Faber, J. (2018) · Endocrine Connections · doi:10.1530/ec-17-0327 · Cited by 38 · see citing works
- Authors
- Ucar, B., Noyan, V., Caglayan, O., Yucel, A., & Sagsoz, N.
- Affiliations
- Kırıkkale University (TR)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2006-10
- Volume
- 86
- Issue
- 4
- Pages
- 942-948
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2029494438
- Cited by
- 5
- References
- 1
- Citations by year
- 2023: 1 · 2018: 1 · 2016: 1 · 2012: 1
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- polycystic ovary syndrome, adrenomedullin, insulin resistance, insulin metabolism, glucose/insulin ratio, gonadotropins, sex steroids, androgens, body mass index, insulin tolerance test
- MeSH terms
- Adolescent, Adult, Female, Humans, Hyperinsulinism, Insulin Resistance, Peptides, Polycystic Ovary Syndrome, Statistics as Topic, Adrenomedullin
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