Imbalance in the peritoneal levels of interleukin 1 and its decoy inhibitory receptor type II in endometriosis women with infertility and pelvic pain
Open accessAbstract
Objective To evaluate the levels of interleukin-1beta (IL1beta) and its inhibitory soluble interleukin-1 receptor type II (IL1R2) in the peritoneal fluid (PF) of normal women and patients with endometriosis suffering from pelvic pain and infertility.Design Retrospective study using ELISA to measure peritoneal fluid IL1beta and soluble IL1R2.Setting Gynecology clinic and human reproduction research laboratory.Patient(s) Sixty-eight normal women and 154 women with endometriosis.Intervention(s) Peritoneal fluid samples were obtained at laparoscopy.Main outcome measure(s) IL1beta and soluble IL1R2 concentrations in the PF samples.Result(s) This study showed a marked decrease in peritoneal soluble IL1R2 levels in women with endometriosis compared to normal women and a concomitant increase in the levels of IL1beta. Both fertile and infertile women with endometriosis had lower soluble IL1R2 and higher IL1beta concentrations than fertile women having a normal gynecological status, but the difference was more significant in infertile endometriosis patients. Compared with normal controls, the decrease in soluble IL1R2 levels was less significant in women with endometriosis than without pelvic pain, whereas the increase in IL1beta concentrations was statistically significant only in women with endometriosis reporting pelvic pain.Conclusion(s) This study revealed an imbalance between IL1beta and its decoy inhibitory receptor type 2 in women with endometriosis, which was particularly obvious in those who were infertile, and suggests that a defect in the local control of IL1 may be involved in the pathophysiology of endometriosis and related infertility.
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Endometriosis is associated with systemic chronic inflammation, increased oxidative stress, and an atherogenic lipid profile.
“Endometriosis has been linked to systemic chronic inflammation, heightened oxidative stress and an atherogenic lipid profile.”
From Endometriosis and Risk of Coronary Heart Disease (2016) · cites this paper as [6]
The Discussion states that endometriosis is associated with a chronic immunoinflammatory reaction frequently observed at both local and systemic levels. The paper does not address heightened oxidative stress or an atherogenic lipid profile; searches for oxidative stress and lipid-profile terms returned no supporting passages. No page number was available in our copy. (LLM, conf=0.90)
Experimental — accuracy not yet measuredInflammatory factors such as interleukin-1, interleukin-6, and tumor necrosis factor-alpha are elevated in peritoneal fluid and peripheral blood of women with endometriosis compared with controls.
“Various inflammatory factors, e.g. interleukin-1, interleukin-6, tumor necrosis factor-α, have been observed to be elevated both in peritoneal fluid (4-6) and the peripheral blood (4, 5, 7) of women with endometriosis compared to controls.”
From Endometriosis and Risk of Coronary Heart Disease (2016) · cites this paper as [6]
The Results (page not available in our copy) report significantly higher interleukin-1β in the peritoneal fluid of women with endometriosis than controls. The paper does not establish that interleukin-6 or tumor necrosis factor-α is elevated there, or that these cytokines are elevated in peripheral blood; its peripheral-blood discussion instead concerns reduced soluble IL-1 receptor type II. (LLM, conf=0.88)
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References 61 · Cited by 78
Research works printed but not linked: 2
- [2]2. Siristatidis C, Nissotakis C, Chrelias C, Iacovidou H, Salamalekis E. Im- munological factors and their role in the genesis and development of en- dometriosis. J Obstet Gynaecol Res 2006;32:162-70.
- [49]49. Taylor RN, Lebovic DI, Mueller MD. Angiogenic factors in endometri- osis. Ann N Y Acad Sci 2002;955:89-100.
- Authors
- Akoum, A., Al-Akoum, M., Lemay, A., Maheux, R., & Leboeuf, M.
- Affiliations
- Centre hospitalier universitaire de Québec (CA)
- Corresponding author
- Akoum, Ali
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 89
- Issue
- 6
- Pages
- 1618-1624
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W1977671182
- Semantic Scholar
- e94aa01b23c97d8155bffe395dd2ff2801d12974
- Cited by
- 78
- References
- 61
- Citations by year
- 2026: 7 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 7 · 2015: 2 · 2014: 6 · 2013: 4 · 2012: 6
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- endometriosis, IL-1β, peritoneal fluid, infertility, pelvic pain, cytokine imbalance, endometriosis pathophysiology
- MeSH terms
- Adult, Ascitic Fluid, Endometriosis, Female, Humans, Infertility, Female, Interleukin-1, Reference Values, Retrospective Studies, Pelvic Pain, Receptors, Interleukin-1 Type II
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