Menstrual cycle length is an age-independent marker of female fertility: results from 6271 treatment cycles of in vitro fertilization
Open accessAbstract
Objective To investigate whether menstrual cycle length correlates with success rates at IVF/intracytoplasmic sperm injection (ICSI) and could be used as a marker of ovarian reserve.Design Prospective observational study.Setting Private infertility centre.Patient(s) A total of 6271 IVF/ICSI treatment cycles.Intervention(s) Self-reported mean number of menstrual days during the last year was recorded before initiation of IVF/ICSI treatment.Main outcome measure(s) Relations between menstrual cycle length and pregnancy and delivery rates.Result(s) Increasing age was associated with a subtle shortening of mean menstrual cycle length. Menstrual cycle length correlated linearly with pregnancy and delivery rates, even after age adjustment. The chance of delivery after IVF/ICSI was almost doubled for women with a menstrual cycle length >34 days compared with women with a menstrual cycle length <26 days. Menstrual cycle length was also significantly associated with ovarian response to FSH/hMG stimulation and embryo quality.Conclusion(s) Mean menstrual cycle length is highly related to success rates in assisted reproduction, independently of age. A precise menstrual cycle history could be used as a simple marker of ovarian reserve.
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The study's findings may be relevant to fertility and contraception because menstrual cycle length appears to be an age-dependent marker of female fertility.
“Since menstrual cycle length appears to be an age-dependent marker of female fertility (46), our findings may prove to be relevant not only to human physiology and behavior but also to fertility and contraception.”
From Women temporarily synchronize their menstrual cycles with the luminance and gravimetric cycles of the Moon (2021) · cites this paper as [46]
The cited claim describes menstrual cycle length as an age-dependent marker of fertility, but the Abstract says its association with assisted-reproduction success is independent of age. The Discussion likewise reports that the associations with implantation, pregnancy and delivery remained significant after correction for age. The paper does observe that cycle length shortens with age; that is distinct from saying its value as a fertility marker depends on age. (LLM, conf=0.92)
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References 31 · Cited by 98
- Authors
- Brodin, T., Bergh, T., Berglund, L., Hadziosmanovic, N., & Holte, J.
- Affiliations
- Uppsala University (SE)
- Uppsala University Hospital (SE)
- Corresponding author
- Brodin, Thomas
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 90
- Issue
- 5
- Pages
- 1656-1661
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2084242682
- Cited by
- 98
- References
- 31
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 8 · 2017: 7 · 2016: 7 · 2015: 8 · 2014: 9 · 2013: 10 · 2012: 2
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- menstrual cycle length, female fertility, ovarian reserve, in vitro fertilization, intracytoplasmic sperm injection, pregnancy rate, live birth rate, ovarian response, embryo quality, age
- MeSH terms
- Adult, Age Factors, Female, Fertilization in Vitro, Follicle Stimulating Hormone, Humans, Infertility, Female, Menotropins, Menstrual Cycle, Ovary, Pregnancy, Prospective Studies, Time Factors, Pregnancy Rate, Live Birth
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