Cited by 339Reproductive Biology and FertilityOvarian function and disordersOvarian cancer diagnosis and treatment

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

RETRACTED: Gonadotropin-releasing hormone agonists for prevention of chemotherapy-induced ovarian damage: prospective randomized study

Open access

Badawy, Ahmed, Elnashar, Aboubakr, El-Ashry, Mohamed, Shahat, May·2009·Fertility and Sterility

DOI 10.1016/j.fertnstert.2007.12.044

Open this paper in CoChat — free account Open PDF

Abstract

Objective To determine whether GnRHa administration before and during combination chemotherapy for breast cancer could preserve posttreatment ovarian function in young women or not. Design Prospective randomized controlled study. Setting Department of Obstetrics and Gynecology, Mansura University Hospital, Mansura, Egypt. Patient(s) Eighty patients with unilateral adenocarcinoma of the breast and with no metastasis who had undergone modified radical mastectomy or breast-conserving surgery plus full axillary lymph node dissection were included in the study. Patients were assigned randomly to receive combined GnRHa and chemotherapy or chemotherapy alone. One woman in each group dropped out. Main outcome measure(s) Return of spontaneous menstruation and ovulation. Hormonal changes (FSH, LH, E(2), P) during and after the course of treatment. Result(s) In the study group, 89.6% resumed menses and 69.2% resumed spontaneous ovulation within 3-8 months of termination of the GnRHa/chemotherapy cotreatment; 11.4% experienced hypergonadotrophic amenorrhoea and ovarian failure 8 months after treatment. In the control group (chemotherapy without GnRHa), 33.3% resumed menses and 25.6% resumed normal ovarian activity. The median FSH and LH concentrations, 6 months after completion of the GnRHa/chemotherapy cotreatment group, were significantly less than the control group. During the GnRHa/chemotherapy cotreatment the concentrations of FSH, LH, and P decreased to almost prepubertal levels. However, within 1-3 months after the last GnRHa injection, an increase in LH and FSH concentrations was detected, followed several weeks later in by an increase in P concentrations to within normal levels. Conclusion(s) GnRHa administration before and during combination chemotherapy for breast cancer may preserve posttreatment ovarian function in women <40 years. Long-term studies are required.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.fertnstert.2007.12.044This paper is marked retracted.

Cites

16 of 16 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cancer: Principles and Practice of Oncology.
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-9-819_4 · Cited by 8,516
Cancer—Principles & Practice of Oncology
Rhoads, J. E. (1983) · PubMed Central · Cited by 1,466
Premature Menopause in Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study
Sklar, C. A., Mertens, A. C., Mitby, P., Whitton, J., Stovall, M., Kasper, C., Mulder, J., Green, D., Nicholson, H. S., Yasui, Y., et al. (2006) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djj243 · Cited by 568
Letter: Serotyping of E. coli.
Rb, S. (1976) · PubMed · Cited by 391
Failure to preserve fertility in patients with Hodgkin's disease
Waxman, J. H., Ahmed, R., Smith, D., Wrigley, P. F. M., Gregory, W., Shalet, S., Crowther, D., Rees, L. H., Besser, G. M., Malpas, J. S., et al. (1987) · Cancer Chemotherapy and Pharmacology · doi:10.1007/bf00254570 · Cited by 319
How to Preserve Fertility in Young Women Exposed to Chemotherapy? The Role of GnRH Agonist Cotreatment in Addition to Cryopreservation of Embrya, Oocytes, or Ovaries
Blumenfeld, Z. (2007) · The Oncologist · doi:10.1634/theoncologist.12-9-1044 · Cited by 275
Endocrinology: Prevention of irreversible chemotherapy-induced ovarian damage in young women with lymphoma by a gonadotrophin-releasing hormone agonist in parallel to chemotherapy
Blumenfeld, Z., Avivi, I., Linn, S., Epelbaum, R., Ben-Shahar, M., & Haim, N. (1996) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a019457 · Cited by 265
Fertility Preservation in Young Women Undergoing Breast Cancer Therapy
Sonmezer, M., & Oktay, K. (2006) · The Oncologist · doi:10.1634/theoncologist.11-5-422 · Cited by 261
PROTECTION FROM CYCLOPHOSPHAMIDE-INDUCED TESTICULAR DAMAGE WITH AN ANALOGUE OF GONADOTROPIN-RELEASING HORMONE
GLODE, L. (1981) · The Lancet · doi:10.1016/s0140-6736(81)92301-1 · Cited by 259
Goserelin as ovarian protection in the adjuvant treatment of premenopausal breast cancer: a phase II pilot study
Recchia, F., Sica, G., Filippis, S. D., Saggio, G., Rosselli, M., & Rea, S. (2002) · Anti-Cancer Drugs · doi:10.1097/00001813-200204000-00011 · Cited by 88

Show all 15 references

Cancer, pregnancy and fertility: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Peccatori, F. A., Azim, H. A., Orecchia, R., Hoekstra, H. J., Pavlidis, N., Kesic, V., & Pentheroudakis, G. (2013) · Annals of Oncology · doi:10.1093/annonc/mdt199 · Cited by 790
Primary ovarian insufficiency
De Vos, M., Devroey, P., & Fauser, B. C. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60355-8 · Cited by 763
Cancer and fertility preservation: international recommendations from an expert meeting
Lambertini, M., Del Mastro, L., Pescio, M. C., Andersen, C. Y., Azim, H. A., Peccatori, F. A., Costa, M., Revelli, A., Salvagno, F., Gennari, A., et al. (2016) · BMC Medicine · doi:10.1186/s12916-015-0545-7 · Cited by 781
Goserelin for Ovarian Protection during Breast-Cancer Adjuvant Chemotherapy
Moore, H. C. F., Unger, J. M., Phillips, K.-A., Boyle, F., Hitre, E., Porter, D., Francis, P. A., Goldstein, L. J., Gomez, H. L., Vallejos, C. S., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1413204 · Cited by 553
Gonadotropin-Releasing Hormone Agonists During Chemotherapy for Preservation of Ovarian Function and Fertility in Premenopausal Patients With Early Breast Cancer: A Systematic Review and Meta-Analysis of Individual Patient–Level Data
Lambertini, M., Moore, H. C. F., Leonard, R. C. F., Loibl, S., Munster, P., Bruzzone, M., Boni, L., Unger, J. M., Anderson, R. A., Mehta, K., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2018.78.0858 · Cited by 393
Effect of the Gonadotropin-Releasing Hormone Analogue Triptorelin on the Occurrence of Chemotherapy-Induced Early Menopause in Premenopausal Women With Breast Cancer: A Randomized Trial
Del Mastro, L., Boni, L., Michelotti, A., Gamucci, T., Olmeo, N., Gori, S., Giordano, M., Garrone, O., Pronzato, P., Bighin, C., et al. (2011) · JAMA · doi:10.1001/jama.2011.991 · Cited by 351
Fertility Preservation in Adolescents and Young Adults With Cancer
Levine, J., Canada, A., & Stern, C. J. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.22.8312 · Cited by 323
Effect of Luteinizing Hormone–Releasing Hormone Agonist on Ovarian Function After Modern Adjuvant Breast Cancer Chemotherapy: The GBG 37 ZORO Study
Gerber, B., von Minckwitz, G., Stehle, H., Reimer, T., Felberbaum, R., Maass, N., Fischer, D., Sommer, H. L., Conrad, B., Ortmann, O., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.32.5704 · Cited by 297
RETIRED: Fertility preservation and reproduction in patients facing gonadotoxic therapies: a committee opinion
(2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.08.041 · Cited by 277
Update on fertility preservation from the Barcelona International Society for Fertility Preservation–ESHRE–ASRM 2015 expert meeting: indications, results and future perspectives
Martínez, F., Andersen, C. Y., Barri, P. N., Brannigan, R. E., Cobo, A., Donnez, J., Dolmans, M., Evers, J. L. H., Féki, A., Goddijn, M., et al. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.05.024 · Cited by 244
Ovarian suppression using luteinizing hormone-releasing hormone agonists during chemotherapy to preserve ovarian function and fertility of breast cancer patients: a meta-analysis of randomized studies
Lambertini, M., Ceppi, M., Poggio, F. B., Peccatori, F. A., Azim, H. A., Ugolini, D., Pronzato, P., Loibl, S., Moore, H. C. F., Partridge, A. H., et al. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv374 · Cited by 231
Gonadotropin-releasing hormone analogues for the prevention of chemotherapy-induced premature ovarian failure in cancer women: Systematic review and meta-analysis of randomized trials
Mastro, L. D., Ceppi, M., Poggio, F. B., Bighin, C., Peccatori, F. A., Demeestere, I., Levaggi, A., Giraudi, S., Lambertini, M., D’Alonzo, A., et al. (2013) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2013.12.001 · Cited by 205
Ovarian Suppression With Triptorelin During Adjuvant Breast Cancer Chemotherapy and Long-term Ovarian Function, Pregnancies, and Disease-Free Survival: A Randomized Clinical Trial
Lambertini, M., Boni, L., Michelotti, A., Gamucci, T., Scotto, T., Gori, S., Giordano, M., Garrone, O., Levaggi, A., Poggio, F. B., et al. (2015) · JAMA · doi:10.1001/jama.2015.17291 · Cited by 205
Female Reproductive Health After Childhood, Adolescent, and Young Adult Cancers: Guidelines for the Assessment and Management of Female Reproductive Complications
Metzger, M. L., Meacham, L. R., Patterson, B. C., Casillas, J., Constine, L. S., Hijiya, N., Kenney, L. B., Leonard, M., Lockart, B. A., Likes, W. M., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.43.5511 · Cited by 201
Adjuvant gonadotropin-releasing hormone analogues for the prevention of chemotherapy induced premature ovarian failure in premenopausal women
Chen, H., Li, J., Cui, T., & Hu, L. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008018.pub2 · Cited by 185
Sex Differences in Systemic Lupus Erythematosus
Nusbaum, J., Mirza, I., Shum, J., Freilich, R. W., Cohen, R. E., Pillinger, M. H., Izmirly, P., & Buyon, J. P. (2020) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2019.09.012 · Cited by 181
Chemotherapy and fertility
Blumenfeld, Z. (2012) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2011.11.008 · Cited by 177
Cancer, fertility and pregnancy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Pentheroudakis, G. E., Orecchia, R., Hoekstra, H. J., & Pavlidis, N. (2010) · Annals of Oncology · doi:10.1093/annonc/mdq198 · Cited by 172
No protection of the ovarian follicle pool with the use of GnRH-analogues or oral contraceptives in young women treated with escalated BEACOPP for advanced-stage Hodgkin lymphoma. Final results of a phase II trial from the German Hodgkin Study Group
Behringer, K., Wildt, L., Mueller, H., Mattle, V., Ganitis, P., van den Hoonard, B., Ott, H. W., Hofer, S., Pluetschow, A., Diehl, V., et al. (2010) · Annals of Oncology · doi:10.1093/annonc/mdq066 · Cited by 168
GnRH agonist for protection against ovarian toxicity during chemotherapy for early breast cancer: the Anglo Celtic Group OPTION trial
Leonard, R. C., Adamson, D. J. A., Bertelli, G., Mansi, J., Yellowlees, A., Dunlop, J. L., Thomas, G. A. O., Coleman, R., & Anderson, R. A. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx184 · Cited by 165
Gonadotropin-releasing hormone analog cotreatment for preservation of ovarian function during gonadotoxic chemotherapy: a systematic review and meta-analysis
Bedaiwy, M. A., Abou-Setta, A. M., Desai, N., Hurd, W. W., Starks, D. C., El‐Nashar, S. A., Al-Inany, H. G., & Falcone, T. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.11.017 · Cited by 162
Gonadotropin-Releasing Hormone Agonists for Ovarian Function Preservation in Premenopausal Women Undergoing Chemotherapy for Early-Stage Breast Cancer: A Systematic Review and Meta-analysis
Munhoz, R. R., Pereira, A. A. L., Sasse, A. D., Hoff, P. M., Traina, T. A., Hudis, C. A., & Marques, R. J. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.3251 · Cited by 160
Breast cancer in young women and its impact on reproductive function
Hickey, M., Peate, M., Saunders, C. M., & Friedlander, M. L. (2009) · Human Reproduction Update · doi:10.1093/humupd/dmn064 · Cited by 154
Gonadatrophin Suppression to Prevent Chemotherapy-Induced Ovarian Damage: A Randomized Controlled Trial
Elgindy, E. A., El-Haieg, D. O., Khorshid, O., Ismail, E. I., Abdelgawad, M. O., Sallam, H. N., & Abou-Setta, A. M. (2013) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31827374e2 · Cited by 152
Prevention of chemotherapy-induced ovarian damage
Roness, H., Kashi, O., & Meirow, D. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.11.043 · Cited by 151
Adolescent and Young Adult Oncology, Version 2.2014
Coccia, P. F., Pappo, A. S., Altman, J. K., Bhatia, R., Borinstein, S. C., Flynn, J. M., Frazier, A. L., George, S., Goldsby, R. E., Hayashi, R. J., et al. (2014) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2014.0004 · Cited by 134
Gonadotropin-Releasing Hormone Agonist for the Prevention of Chemotherapy-Induced Ovarian Failure in Patients With Lymphoma: 1-Year Follow-Up of a Prospective Randomized Trial
Demeestere, I., Brice, P., Peccatori, F. A., Kentos, A., Gaillard, I., Zachée, P., Casasnovas, O., Neste, É. V. D., Dechène, J., Maertelaer, V. D., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2012.42.8185 · Cited by 129
Ovarian protection with gonadotropin-releasing hormone agonists during chemotherapy in cancer patients: From biological evidence to clinical application
Lambertini, M., Horicks, F., Mastro, L. D., Partridge, A. H., & Demeestere, I. (2018) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2018.11.006 · Cited by 126
Adjuvant gonadotropin-releasing hormone analogues for the prevention of chemotherapy-induced premature ovarian failure in premenopausal women
Chen, H., Xiao, L., Li, J., Cui, L., & Huang, W. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008018.pub3 · Cited by 122
Protecting Ovaries During Chemotherapy Through Gonad Suppression: A Systematic Review and Meta-analysis
Elgindy, E. A., Sibai, H., Abdelghani, A., & Mostafa, M. I. (2015) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000000905 · Cited by 118
Practical recommendations for fertility preservation in women by the FertiPROTEKT network. Part I: Indications for fertility preservation
Schüring, A. N., Fehm, T. N., Behringer, K., Goeckenjan, M., Wimberger, P., Henes, M., Henes, J., Fey, M. F., & von Wolff, M. (2017) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-017-4594-3 · Cited by 116
Options on fertility preservation in female cancer patients
Rodriguez‐Wallberg, K. A., & Oktay, K. (2011) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2011.10.002 · Cited by 113
Risk of ovarian failure and fertility preserving methods in girls and adolescents with a malignant disease
Schmidt, K., Larsen, E. C., Andersen, C. Y., & Andersen, A. N. (2009) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2009.02408.x · Cited by 111
Prevention of chemotherapy-induced ovarian damage: possible roles for hormonal and non-hormonal attenuating agents
Roness, H., Kalich‐Philosoph, L., & Meirow, D. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu019 · Cited by 109
Fertility and gonadal function in female survivors after treatment of early unfavorable Hodgkin lymphoma (HL) within the German Hodgkin Study Group HD14 trial
Behringer, K., Thielen, I., Mueller, H., Goergen, H., Eibl, A. D., Rosenbrock, J., Halbsguth, T. V., Eichenauer, D. A., Fuchs, M., Reiners, K. S., et al. (2012) · Annals of Oncology · doi:10.1093/annonc/mdr575 · Cited by 107
Temporary ovarian suppression during chemotherapy to preserve ovarian function and fertility in breast cancer patients: A GRADE approach for evidence evaluation and recommendations by the Italian Association of Medical Oncology
Lambertini, M., Cinquini, M., Moschetti, I., Peccatori, F. A., Anserini, P., Menada, M. V., Tomirotti, M., & Mastro, L. D. (2016) · European Journal of Cancer · doi:10.1016/j.ejca.2016.10.034 · Cited by 95
In vivo delivery of FTY720 prevents radiation-induced ovarian failure and infertility in adult female nonhuman primates
Zelinski, M. B., Murphy, M. K., Lawson, M. S., Jurisicova, A., Pau, K. ‐. F., Toscano, N. P., Jacob, D., Fanton, J., Casper, R. F., Dertinger, S. D., et al. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.01.012 · Cited by 93
Fertility preservation after chemotherapy for Hodgkin lymphoma
van der Kaaij, M. A. E., van Echten‐Arends, J., Simons, A., & Kluin‐Nelemans, H. C. (2010) · Hematological Oncology · doi:10.1002/hon.939 · Cited by 93
Update on fertility preservation from the Barcelona International Society for Fertility Preservation–ESHRE–ASRM 2015 expert meeting: indications, results and future perspectives†‡
Martínez, F. (2017) · Human Reproduction · doi:10.1093/humrep/dex218 · Cited by 93
Fertility issues in cancer survivorship
Kort, J., Eisenberg, M. L., Millheiser, L. S., & Westphal, L. M. (2013) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21205 · Cited by 89
Pregnancy after breast cancer: if you wish, ma’am
Pagani, O., Partridge, A. H., Korde, L. A., Badve, S., Bartlett, J. M. S., Albain, K. S., Gelber, R. D., & Goldhirsch, A. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1643-7 · Cited by 89
Pharmacological interventions for fertility preservation during chemotherapy: a systematic review and meta-analysis
Ben‐Aharon, I., Gafter‐Gvili, A., Leibovici, L., & Stemmer, S. M. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-0996-7 · Cited by 88
Utility of gonadotropin-releasing hormone agonists for fertility preservation in young breast cancer patients: the benefit remains uncertain
Turner, N. H., Partridge, A. H., Sanna, G., Leo, A. D., & Biganzoli, L. (2013) · Annals of Oncology · doi:10.1093/annonc/mdt196 · Cited by 88
The Japanese Breast Cancer Society Clinical Practice Guideline for systemic treatment of breast cancer, 2015 edition
Aihara, T., Toyama, T., Takahashi, M., Yamamoto, Y., Hara, F., Akabane, H., Fujisawa, T., Ishikawa, T., Nagai, S. E., Nakamura, R., et al. (2016) · Breast Cancer · doi:10.1007/s12282-016-0670-y · Cited by 88
Fertility preservation in women of reproductive age with cancer
McLaren, J. F., & Bates, G. W. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2012.08.013 · Cited by 84
Gonadotropin‐releasing hormone agonists for ovarian protection during cancer chemotherapy: systematic review and meta‐analysis
Senra, J. C., Roque, M., Talim, M. C. T., dos Reis, F. M., & Tavares, R. L. C. (2017) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.18934 · Cited by 84
Use of Hormonal Protection for Chemotherapy-induced Gonadotoxicity
Kim, S. S., Lee, J. R., Jee, B. C., Suh, C. S., Kim, S. H., Ting, A. Y., & Petroff, B. K. (2010) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0b013e3181f96cb1 · Cited by 80
Fertility Preservation
Jensen, J. R., Morbeck, D. E., & Coddington, C. C. (2010) · Mayo Clinic Proceedings · doi:10.4065/mcp.2010.0564 · Cited by 80
Concurrent treatment with gonadotropin-releasing hormone agonists for chemotherapy-induced ovarian damage in premenopausal women with breast cancer: A meta-analysis of randomized controlled trials
Yang, B. Y., Shi, W., Yang, J., Liu, H., Zhao, H., Li, X., & Jiao, S. (2013) · The Breast · doi:10.1016/j.breast.2012.12.008 · Cited by 79
Chemotherapy in Pregnancy
Brewer, M., Kueck, A. S., & Runowicz, C. D. (2011) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0b013e318236e9f9 · Cited by 79
Chemotherapy-induced ovarian toxicity in patients affected by endocrine-responsive early breast cancer
Torino, F., Barnabei, A., Vecchis, L. D., Sini, V., Schittulli, F., Marchetti, P., & Corsello, S. M. (2013) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2013.07.007 · Cited by 79
Breast cancer and fertility preservation
Kim, S. S., Klemp, J. R., & Fabian, C. J. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.01.003 · Cited by 79
Goserelin with chemotherapy to preserve ovarian function in pre-menopausal women with early breast cancer: menstruation and pregnancy outcomes
Wong, M., O'Neill, S., Walsh, G., & Smith, I. E. (2012) · Annals of Oncology · doi:10.1093/annonc/mds250 · Cited by 75
Gonadotropin-releasing hormone agonist may minimize premature ovarian failure in young women undergoing autologous stem cell transplantation
Blumenfeld, Z., Patel, B. V., Leiba, R., & Zuckerman, T. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.07.1144 · Cited by 70
Granulocyte colony-stimulating factor with or without stem cell factor extends time to premature ovarian insufficiency in female mice treated with alkylating chemotherapy
Skaznik-Wikiel, M. E., McGuire, M. M., Sukhwani, M., Donohue, J., Chu, T., Krivak, T. C., Rajkovic, A., & Orwig, K. E. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.01.135 · Cited by 69
Breastfeeding in breast cancer survivors: Pattern, behaviour and effect on breast cancer outcome
Azim, H. A., Bellettini, G., Liptrott, S. J., Armeni, M. E., Dell’Acqua, V., Torti, F., Nubila, B. D., Galimberti, V. E., & Peccatori, F. A. (2010) · The Breast · doi:10.1016/j.breast.2010.05.018 · Cited by 69
Fertility considerations in young women with hematological malignancies
Jadoul, P., & Kim, S. S. (2012) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-012-9792-0 · Cited by 68
Effect of leuprolide acetate on ovarian function after cyclophosphamide–doxorubicin-based chemotherapy in premenopausal patients with breast cancer: results from a phase II randomized trial
Gui-ping, S., Gao, H. Y., & Yuan, Z. (2013) · Medical Oncology · doi:10.1007/s12032-013-0667-8 · Cited by 67
Assisted reproductive techniques after fertility-sparing treatments in gynaecological cancers
Zapardiel, I., Cruz, M., Diestro, M. D., Requena, A., & García-Velasco, J. A. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmv066 · Cited by 67
Data integrity of 35 randomised controlled trials in women' health
Bordewijk, E. M., Wang, R., Askie, L. M., Gurrin, L. C., Thornton, J. G., van Wely, M., Li, W., & Mol, B. W. (2020) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2020.04.016 · Cited by 66
Protection from cyclophosphamide-induced ovarian damage with bone marrow-derived mesenchymal stem cells during puberty
Kılıç, S., Pınarlı, F. A., Özoğul, C., Taşdemir, N., Sarac, G. N., & Delibaşı, T. (2013) · Gynecological Endocrinology · doi:10.3109/09513590.2013.860127 · Cited by 65
GnRH agonist leuprolide acetate does not confer any protection against ovarian damage induced by chemotherapy and radiationin vitro
Bildik, G., Akin, N., Senbabaoglu, F., Şahin, G. N., Karahüseyinoğlu, S., İnce, Ü., Taşkıran, Ç., Selek, U., Yakın, K., Güzel, Y., et al. (2015) · Human Reproduction · doi:10.1093/humrep/dev257 · Cited by 65
Long-term follow-up of autologous hematopoietic stem cell transplantation for severe refractory Crohn's disease
Hommes, D. W., Duijvestein, M., Zelinková, Z., Stokkers, P. C. F., de Ley, M., Stoker, J., Voermans, C., van Oers, M. H. J., & Kersten, M. J. (2011) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2011.05.004 · Cited by 63
‘An ounce of prevention is worth a pound of cure’: the case for and against GnRH-agonist for fertility preservation
Blumenfeld, Z., Katz, G., & Evron, A. (2014) · Annals of Oncology · doi:10.1093/annonc/mdu036 · Cited by 62
Gonadotropin-Releasing Hormone Analog Cotreatment for the Preservation of Ovarian Function during Gonadotoxic Chemotherapy for Breast Cancer: A Meta-Analysis
Wang, C., Chen, M., Fu, F., & Huang, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066360 · Cited by 61
Factors associated with ovarian function recovery after chemotherapy for breast cancer: a systematic review and meta-analysis
Silva, C., Caramelo, O. L., Almeida‐Santos, T., & Rama, A. C. R. (2016) · Human Reproduction · doi:10.1093/humrep/dew224 · Cited by 61
Fertility considerations in the management of gynecologic malignancies
Noyes, N. L., Knopman, J. M., Long, K. C., Coletta, J. M., & Abu‐Rustum, N. R. (2010) · Gynecologic Oncology · doi:10.1016/j.ygyno.2010.09.012 · Cited by 60
Gonadotropin-releasing hormone agonists for the preservation of ovarian function among women with breast cancer who did not use tamoxifen after chemotherapy: a systematic review and meta-analysis
Vitek, W., Shayne, M., Hoeger, K. M., Han, Y., Messing, S. P., & Fung, C. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.06.003 · Cited by 60
The role of peripheral gonadotropin-releasing hormone receptors in female reproduction
Yu, B., Ruman, J. I., & Christman, G. M. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.08.045 · Cited by 58
Fertility preservation medicine: A new field in the care of young cancer survivors
Oktay, K., & Öktem, Ö. (2009) · Pediatric Blood & Cancer · doi:10.1002/pbc.22003 · Cited by 57
Preservation of gonadal function in women undergoing chemotherapy: a systematic review and meta-analysis of the potential role for gonadotropin-releasing hormone agonists
Hickman, L. C., Llarena, N. C., Valentine, L. N., Liu, X., & Falcone, T. (2018) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-018-1128-2 · Cited by 57
Combination of a GnRH agonist with an antagonist prevents flare-up effects and protects primordial ovarian follicles in the rat ovary from cisplatin-induced toxicity: a controlled experimental animal study
Li, X., Kang, X., Deng, Q., Cai, J., & Wang, Z. (2013) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-11-16 · Cited by 56
Efficacy and safety of ovarian stimulation before chemotherapy in 205 cases
Lawrenz, B., Jauckus, J., Kupka, M. S., Strowitzki, T., & von Wolff, M. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.06.054 · Cited by 55
A changing perspective: improving access to fertility preservation
Letourneau, J. M., Melisko, M., Cedars, M. I., & Rosen, M. P. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.133 · Cited by 54
Adjunctive GnRH-a treatment attenuates depletion of ovarian reserve associated with cyclophosphamide therapy in premenopausal SLE patients
Marder, W., McCune, W. J., Wang, L., Wing, J. J., Fisseha, S., McConnell, D. S., Christman, G. M., & Somers, E. C. (2012) · Gynecological Endocrinology · doi:10.3109/09513590.2011.650752 · Cited by 53
Gonadotropin Releasing Hormone Agonists May Minimize Cyclophosphamide Associated Gonadotoxicity in SLE and Autoimmune Diseases
Blumenfeld, Z., Mischari, O., Schultz, N., Boulman, N., & Balbir‐Gurman, A. (2011) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2011.05.008 · Cited by 53
Melatonin and Fertoprotective Adjuvants: Prevention against Premature Ovarian Failure during Chemotherapy
Jang, H. S., Hong, K., & Choi, Y. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061221 · Cited by 51
Motherhood after breast cancer: searching for la dolce vita
Azim, H. A., Peccatori, F. A., de Azambuja, E., & Piccart, M. J. (2011) · Expert Review of Anticancer Therapy · doi:10.1586/era.10.208 · Cited by 50
How does bone marrow transplantation affect ovarian function and fertility?
Jadoul, P., & Donnez, J. (2012) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e328353bb57 · Cited by 49
Reproductive issues in patients undergoing Hematopoietic Stem Cell Transplantation: an update
Guida, M., Castaldi, M. A., Rosamilio, R., Giudice, V., Orio, F., & Selleri, C. (2016) · Journal of Ovarian Research · doi:10.1186/s13048-016-0279-y · Cited by 49
Utility of gonadotropin-releasing hormone agonists for prevention of chemotherapy-induced ovarian damage in premenopausal women with breast cancer: a systematic review and meta-analysis
Shen, Y. W., Zhang, X. M., Lv, M., Wang, F., Qin, T. J., Chen, L., Liu, P. J., Yang, J., & Jiao, Y. (2015) · OncoTargets and Therapy · doi:10.2147/ott.s95936 · Cited by 48
Fertility considerations and preservation in haemato‐oncology patients undergoing treatment
Leader, A., Lishner, M., Michaeli, J., & Revel, A. (2011) · British Journal of Haematology · doi:10.1111/j.1365-2141.2011.08629.x · Cited by 47
Preserving fertility when choosing chemotherapy regimens – the role of gonadotropin-releasing hormone agonists
Blumenfeld, Z., & Evron, A. (2015) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2015.1031654 · Cited by 46
Strategies for fertility preservation in young early breast cancer patients
Cont, N. T., Lambertini, M., Hulsbosch, S., Peccatori, F. A., & Amant, F. C. (2014) · The Breast · doi:10.1016/j.breast.2014.05.024 · Cited by 45
Fertility Preservation in Reproductive-Age Women Facing Gonadotoxic Treatments
Roberts, J., Ronn, R., Tallon, N., & Holzer, H. E. G. (2015) · Current Oncology · doi:10.3747/co.22.2334 · Cited by 44
Update on fertility preservation in young women undergoing breast cancer and ovarian cancer therapy
Lambertini, M., Ginsburg, E. S., & Partridge, A. H. (2014) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000138 · Cited by 44
GnRH analogs do not protect ovaries from chemotherapy-induced ultrastructural injury in Hodgkin’s lymphoma patients
Nitzschke, M., Raddatz, J., Bohlmann, M. K., Stute, P., Strowitzki, T., & von Wolff, M. (2009) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-009-1308-5 · Cited by 44
Ovarian Reserve Disorders, Can We Prevent Them? A Review
Man, L., Guahmich, N. L., Vyas, N., Tsai, S., Arazi, L., Lilienthal, D., Schattman, G. L., Rosenwaks, Z., & James, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315426 · Cited by 43
Fertility counseling of young breast cancer patients.
Lambertini, M., Anserini, P., Levaggi, A., Poggio, F. B., & Mastro, L. D. (2013) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2072-1439.2013.05.22 · Cited by 42
Cancer and fertility: strategies to preserve fertility
Diedrich, K., Fauser, B. C. J. M., & Devroey, P. (2010) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2010.11.001 · Cited by 41
Fertility-preservation in endometrial cancer: is it safe? Review of the literature
Carneiro, M. M., Lamaita, R. M., Ferreira, M. C. F., & Filho, A. L. D. S. (2016) · JBRA · doi:10.5935/1518-0557.20160045 · Cited by 41
Preservation of fertility in adults and children diagnosed with cancer
Hart, R. J. (2008) · BMJ · doi:10.1136/bmj.a2045 · Cited by 41
The Roles of Different Stem Cells in Premature Ovarian Failure
Zhang, C. (2019) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x14666190314123006 · Cited by 40
Steroids - From Physiology to Clinical Medicine
Ostojić, S. M. (2012) · InTech eBooks · doi:10.5772/46119 · Cited by 40
Medical approaches to preservation of fertility in female cancer patients
Mastro, L. D., Giraudi, S., Levaggi, A., & Pronzato, P. (2011) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2011.522568 · Cited by 39
Reproductive Outcomes and Fertility Preservation Strategies in Women with Malignant Ovarian Germ Cell Tumors after Fertility Sparing Surgery
Vasta, F. M., Dellino, M., Bergamini, A., Gargano, G., Paradiso, A., Loizzi, V., Bocciolone, L., Silvestris, E., Petrone, M., Cormio, G., et al. (2020) · Biomedicines · doi:10.3390/biomedicines8120554 · Cited by 38
Fertility and Reproductive Considerations in Premenopausal Patients with Breast Cancer
Lee, M. C., Gray, J. E., Han, H. S., & Plosker, S. M. (2010) · Cancer Control · doi:10.1177/107327481001700304 · Cited by 37
How to Protect Ovarian Function before and during Chemotherapy?
Arecco, L., Ruelle, T., Martelli, V., Boutros, A., Latocca, M. M., Spinaci, S., Marrocco, C., Massarotti, C., & Lambertini, M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10184192 · Cited by 37
Fertility Management After Breast Cancer Diagnosis: A Qualitative Investigation of Women's Experiences of and Recommendations for Professional Care
Kirkman, M., Stern, C. J., Neil, S., Winship, I., Mann, G. B., Shanahan, K., Missen, D., Shepherd, H., & Fisher, J. (2012) · Health Care For Women International · doi:10.1080/07399332.2012.735729 · Cited by 37
Preservation of Fertility in Patients with Cancer
Lee, S. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmc090614 · Cited by 37

Authors: Badawy, A., Elnashar, A., El-Ashry, M., & Shahat, M.
Affiliations: Mansoura University (EG)
Benha University (EG)
Corresponding author: Badawy, Ahmed
ORCID: Badawy, Ahmed
Elnashar, Aboubakr
Venue: Fertility and Sterility
Publisher: Elsevier BV
Published: 2009-03
Volume: 91
Issue: 3
Pages: 694-697
ISSN: 0015-0282 (ISSN-L)
DOI: 10.1016/j.fertnstert.2007.12.044
OpenAlex: W2101897761
Cited by: 331
References: 15
Citations by year: 2026: 4 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 9 · 2020: 5 · 2019: 14 · 2018: 12 · 2017: 18 · 2016: 14 · 2015: 21 · 2014: 23 · 2013: 31 · 2012: 50
FWCI: 35.35
Type: journal article
Language: en
Status: Retracted
Update notices: retraction (2023-07-27)
retraction (2009-03-01)
erratum (2023-08-01)
retraction (2023-07-27)
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Fertility and Sterility (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Oncology › Ovarian cancer diagnosis and treatment
Keywords: GnRH agonist, chemotherapy-induced ovarian damage, breast cancer, ovarian preservation, chemotherapy-induced amenorrhea, ovarian failure, FSH and LH levels, estrogen and progesterone, young women
MeSH terms: Adenocarcinoma, Adult, Amenorrhea, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Drug Administration Schedule, Estradiol, Female, Fertility Agents, Female, Humans, Infertility, Female, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Lymph Node Excision, Mastectomy, Menstruation, Ovary, Ovulation, Progesterone, Prospective Studies, Time Factors, Primary Ovarian Insufficiency, Treatment Outcome, Chemotherapy, Adjuvant, Goserelin, Follicle Stimulating Hormone, Human

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

RETRACTED: Gonadotropin-releasing hormone agonists for prevention of chemotherapy-induced ovarian damage: prospective randomized study

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks

Data sources