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Cited by 80Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsGenetic and Kidney Cyst Diseases

Basal metabolic rate is decreased in women with polycystic ovary syndrome and biochemical hyperandrogenemia and is associated with insulin resistance

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Georgopoulos, Neoklis A., Saltamavros, Alexandros D., Vervita, Vasiliki, Karkoulias, Kyriakos, Adonakis, George, Decavalas, George, Kourounis, George, Markou, Kostas B. +1 more·2009·Fertility and Sterility
DOI 10.1016/j.fertnstert.2008.04.067
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Abstract

Objective To evaluate basal metabolic rate (BMR) in women with PCOS and to determine its association with insulin resistance (IR). Design Prospective assessment of BMR in women with PCOS. Setting Outpatient clinic of the Division of Reproductive Endocrinology. Patient(s) The study included 91 Greek women with PCOS and biochemical hyperandrogenemia, with mean age 24.03 +/- 0.55 years and mean body mass index (BMI) 26.67 +/- 0.69 kg/m(2), and 48 matched regularly menstruating women, with mean age 26.33 +/- 0.93 years and mean BMI 23.35 +/- 0.85 kg/m(2), as control subjects. Intervention(s) Assessment of BMR by indirect calorimetry, IR by HOMA and QUICKI indices, fasting insulin, and fasting glucose/insulin ratio. Main outcome measure(s) Reduced BMR in PCOS with or without IR. Result(s) Adjusted BMR was 1,868 +/- 41 kcal/day in the control group, 1,445.57 +/- 76 in all PCOS women, 1,590 +/- 130 in PCOS women without IR and 1,116 +/- 106 in PCOS women with IR. Adjusted BMR showed a statistically significant difference between women with PCOS and control subjects, with lowest values in the group of PCOS women with IR, even after adjusting all groups for age and BMI. Conclusion(s) Women with PCOS, particularly those with IR, present a significantly decreased BMR.

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  • Alterations in energy expenditure or metabolic inflexibility have been associated with insulin resistance and hyperandrogenism in PCOS.

    “Further, these alterations in energy expenditure or metabolic inflexibility have been associated with insulin resistance [25,26,34] and hyperandrogenism [34].”

    From Providing lifestyle advice to women with PCOS: an overview of practical issues affecting success (2021) · cites this paper as [25]

  • The limited literature has reported decreases in basal metabolic rate or postprandial thermogenesis for women with PCOS compared to those without, although this is not consistently found.

    “The limited literature in this area has reported decreases in basal metabolic rate [25] or postprandial thermogenesis [26] for women with PCOS compared to those without, although this is not consistently found [26][27][28][29].”

    From Providing lifestyle advice to women with PCOS: an overview of practical issues affecting success (2021) · cites this paper as [25]

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References 37 · Cited by 80

Research works printed but not linked: 27

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Authors
Georgopoulos, N. A., Saltamavros, A. D., Vervita, V., Karkoulias, K., Adonakis, G., Decavalas, G., Kourounis, G., Markou, K. B., & Kyriazopoulou, V.
Affiliations
University of Patras (GR)
Corresponding author
Georgopoulos, Neoklis A.
ORCID
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2009-07
Volume
92
Issue
1
Pages
250-255
ISSN
0015-0282 (ISSN-L)
DOI
10.1016/j.fertnstert.2008.04.067
OpenAlex
W2057326698
Cited by
80
References
37
Citations by year
2026: 3 · 2025: 4 · 2024: 4 · 2023: 10 · 2022: 4 · 2021: 4 · 2020: 6 · 2019: 10 · 2018: 4 · 2017: 7 · 2016: 3 · 2015: 6 · 2014: 3 · 2013: 2 · 2012: 3
FWCI
2.70
Type
journal article
Language
en
Open access
Licence
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords
polycystic ovary syndrome, basal metabolic rate, insulin resistance, hyperandrogenemia, energy expenditure, HOMA-IR, QUICKI, fasting insulin, body mass index
MeSH terms
Adult, Basal Metabolism, Body Composition, Female, Greece, Humans, Insulin Resistance, Polycystic Ovary Syndrome, Prospective Studies, Reference Values, Hyperandrogenism, Young Adult

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