A double-blind placebo-controlled trial investigating the efficacy of 12 weeks of dienogest 2 mg/day for the treatment of endometriosis-associated pain
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Dienogest at a dose of 2 mg once daily was similarly associated with only moderate decreases in estradiol levels in a 12-week placebo-controlled study and in a 1-year extension study.
“Dienogest at a dose of 2 mg once daily was similarly associated with only moderate decreases in estradiol levels in a 12-week placebo-controlled study and in a 1-year extension study (Seitz et al., 2008(Seitz et al., , 2009)).”
From Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, open-label trial (2010) · cites this paper as Seitz et al., 2008
In clinical trials, dienogest was shown to be an effective and well-tolerated treatment for endometriosis.
“In clinical trials, including a dose-response study (Ko ¨hler et al., 2010), a placebo-controlled study (Seitz et al., 2008), an activecontrolled study versus triptorelin after laparoscopic surgery (Cosson et al., 2002) and a long-term safety study (Seitz et al., 2009), dienogest was shown to be an effective and well-tolerated treatment for endometriosis.”
From Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, open-label trial (2010) · cites this paper as Seitz et al., 2008
The safety and tolerability findings from the current trial support the findings of previous studies of dienogest in endometriosis.
“The safety and tolerability findings from the current trial support the findings of previous studies of dienogest in endometriosis (Ko ¨hler et al., 1989(Ko ¨hler et al., , 2010;;Schindler et al., 2006;Seitz et al., 2008;Harada et al., 2009).”
From Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, open-label trial (2010) · cites this paper as Seitz et al., 2008
Dienogest appears to have no relevant effect on lipids and lacks androgenic side effects.
“Dienogest, in contrast, appears to have no relevant effect on lipids (Ko ¨hler et al., 1989;Schindler et al., 2006;Seitz et al., 2008) and lacks androgenic side effects (Oettel et al., 1999;Schindler et al., 2003).”
From Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, open-label trial (2010) · cites this paper as Seitz et al., 2008
Other studies that examined bleeding patterns during dienogest treatment, including the 1-year extension study, also reported progressive reductions in bleeding irregularity over time.
“Other studies that examined bleeding patterns during dienogest treatment, including the 1-year extension study, also reported progressive reductions in bleeding irregularity over time (Cosson et al., 2002;Seitz et al., 2008Seitz et al., , 2009;;Ko ¨hler et al., 2010).”
From Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, open-label trial (2010) · cites this paper as Seitz et al., 2008
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Cited by 7
- Authors
- Seitz, C., Gerlinger, C., Marr, J., & Schürmann, R.
- Affiliations
- Bayer (Germany) (DE)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 90
- Pages
- S140
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2094239157
- Cited by
- 7
- References
- 0
- Citations by year
- 2021: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 2
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, rescue medication, ibuprofen, analgesia, drug safety and tolerability, visual analogue scale
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