Signs of reduced angiogenic activity after surgical removal of deeply infiltrating endometriosis
Open accessAbstract
Objective To study the concentrations of vascular endothelial growth factor A (VEGF-A), soluble vascular endothelial growth factor receptors-1 and -2 (sVEGFR-1 and -2), angiogenin, and angiopoietin-2 (Ang-2) in serum and peritoneal fluid from healthy controls and women with advanced endometriosis. Further, we addressed the question of whether surgical removal of endometriotic lesions was associated with normalization of the serum concentrations of the same markers.Design Patients with endometriosis before and after surgery were compared with control patients.Setting University Hospital.Patient(s) Twenty-one healthy controls and 32 women with advanced endometriosis.Intervention(s) In women with endometriosis we performed surgical removal of endometriotic lesions using laparoscopy.Main outcome measure(s) Data on serum and peritoneal fluid concentrations of selected markers in healthy controls and women with endometriosis before surgery and in serum 5 to 7 days after surgery.Result(s) Women with endometriosis had elevated levels of VEGF-A, sVEGFR-1, and Ang-2 in serum and all studied markers in peritoneal fluid compared with healthy controls. Surgical removal of endometriotic lesions resulted in decreased serum levels of pro-angiogenic VEGF-A and increased levels of sVEGFR-2 that negatively regulates the action of VEGF.Conclusion(s) Women with advanced endometriosis have serum and peritoneal fluid concentrations of several factors involved in the regulation of angiogenesis that differ from those in healthy women, and these changes at least partly normalize within a week after surgical removal of the endometriotic lesions.
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Follow-up of patients with advanced endometriosis showed reduced VEGF-A levels after laparoscopic excision of the lesions.
“Follow-up of patients with advanced endometriosis showed reduced VEGF-A levels after laparoscopic excision of the lesions [68, 69].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [69]
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References 54 · Cited by 57
Research works printed but not linked: 1
- Taylor RN, Lebovic DI, Mueller MD. Angiogenic factors in endometri- osis. Ann N Y Acad Sci 2002;955:89-100.
- Authors
- Bourlev, V., Iljasova, N., Adamyan, L., Larsson, A., & Olovsson, M.
- Affiliations
- Uppsala University (SE)
- Corresponding author
- Olovsson, Matts
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 94
- Issue
- 1
- Pages
- 52-57
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2084814314
- Cited by
- 57
- References
- 54
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 7 · 2017: 3 · 2016: 5 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 3
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Russian Academy of Medical Sciences
- Vetenskapsrådet (8683)
- Svenska Läkaresällskapet
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, angiogenesis, VEGF-A, soluble VEGF receptor, angiopoietin-2, angiogenin, peritoneal fluid, serum biomarkers, laparoscopic surgery, advanced endometriosis
- MeSH terms
- Ascitic Fluid, Endometriosis, Endometrium, Female, Humans, Neovascularization, Pathologic, Biomarkers, Down-Regulation, Up-Regulation, Vascular Endothelial Growth Factor Receptor-1, Vascular Endothelial Growth Factor A, Angiopoietin-2
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