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Cited by 125Ovarian function and disordersReproductive Health and TechnologiesAssisted Reproductive Technology and Twin Pregnancy

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Factors associated with ovarian hyperstimulation syndrome (OHSS) and its effect on assisted reproductive technology (ART) treatment and outcome

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Luke, Barbara, Brown, Morton B., Morbeck, Dean E., Hudson, Susan B., Coddington, Charles C., Stern, Judy E.·2010·Fertility and Sterility
DOI 10.1016/j.fertnstert.2009.05.092
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Abstract

Objective To evaluate factors associated with ovarian hyperstimulation syndrome (OHSS) and its effect on assisted reproductive technology (ART) treatment and outcome. Design Historic cohort study. Setting Clinic-based data. Patient(s) The population included 214,219 ART cycles performed during 2004 to 2006 and reported to the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System Online database. The study population was limited to cycles of autologous, fresh embryo transfers to women without any treatment complications (212,041), and those developing moderate (1,523) or severe (655) OHSS. Intervention(s) None. Main outcome measure(s) Risk factors for developing OHSS, and its effect on achieving a pregnancy and live birth, as adjusted odds ratios. Result(s) Compared with white women, the risk of developing OHSS was increased for Black women (any OHSS, 1.88; severe OHSS, 2.93) and decreased for Hispanic women (any OHSS, 0.79). Ovarian hyperstimulation syndrome was associated with ovulation disorders (2.01), tubal factors (1.24), and unexplained factors (1.36). Ovarian hyperstimulation syndrome increased the odds of achieving a pregnancy (1.98 with any OHSS, 2.68 with severe), a live birth (any OHSS, 1.86), and a multiple live birth (1.58 with any OHSS, 1.86 with severe). The presence of any OHSS increased the risk of an adverse pregnancy outcome (stillbirth, low birthweight, or preterm birth) by 26% and low birthweight among singletons by 40%. Conclusion(s) Ovarian hyperstimulation syndrome is associated with a higher likelihood of pregnancy, and multiple gestations, but also greater risks for adverse pregnancy outcomes.

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Research works printed but not linked: 35

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Cited by

Sorted by citations

  • Endometriosis and polycystic ovary syndrome are diametric disorders

    Dinsdale, N. L., & Crespi, B. J. (2021) · Evolutionary Applications · doi:10.1111/eva.13244 · Cited by 90

    “PCOS is also associated with an increased risk of ovarian hyperstimulation syndrome, a serious condition resulting from supraphysiologic levels of gonadotropins (Kumar et al., 2011; Tummon et al., 2005), whereas endometriosis involves a decreased risk of this syndrome (Luke et al., 2010).”
    Background

Metadata

Authors
Luke, B., Brown, M. B., Morbeck, D. E., Hudson, S. B., Coddington, C. C., & Stern, J. E.
Affiliations
  • Michigan State University (US)
  • University of Michigan (US)
  • Mayo Clinic (US)
  • Dartmouth–Hitchcock Medical Center (US)
ORCID
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2010-09
Volume
94
Issue
4
Pages
1399-1404
ISSN
0015-0282 (ISSN-L)
DOI
10.1016/j.fertnstert.2009.05.092
OpenAlex
W2104430393
Cited by
125
References
0
Citations by year
2026: 2 · 2025: 16 · 2024: 6 · 2023: 12 · 2022: 11 · 2021: 16 · 2020: 10 · 2019: 11 · 2018: 8 · 2017: 4 · 2016: 4 · 2015: 7 · 2014: 7 · 2013: 6 · 2012: 3
FWCI
1.97
Type
journal article
Language
en
Open access
Licence
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
Funders
SART
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
Keywords
ovarian hyperstimulation syndrome, assisted reproduction, fresh embryo transfer, OHSS risk factors, racial and ethnic differences, ovulatory dysfunction, tubal factors, unexplained infertility, live birth, multiple pregnancy, adverse pregnancy outcomes, low birth weight, preterm birth, stillbirth
MeSH terms
Adult, Ethnicity, Female, Humans, Infant, Newborn, Pregnancy, Pregnancy Outcome, Risk Factors, Cohort Studies, Ovarian Hyperstimulation Syndrome, Treatment Outcome, Pregnancy Rate, Reproductive Techniques, Assisted, Live Birth

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