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Cited by 205Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsEndometriosis Research and Treatment

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Clinical and endocrine characteristics of the main polycystic ovary syndrome phenotypes

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Guastella, Ettore, Longo, Rosa Alba, Carmina, Enrico·2010·Fertility and Sterility
DOI 10.1016/j.fertnstert.2010.02.014
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Abstract

Objective To evaluate the clinical and endocrine differences between main polycystic ovary syndrome (PCOS) phenotypes.Design To evaluate clinical and hormone parameters in a large group of consecutive women with PCOS diagnosed according Rotterdam criteria and divided according their phenotype.Setting University department of medicine.Patient(s) Three hundred eighty-two consecutive women with PCOS and 85 ovulatory controls.Intervention(s) Evaluation of clinical and hormone parameters.Main outcome measure(s) Blood levels of gonadotropins, testosterone, sex-hormone-binding globulin, dehydroepiandrosterone sulfate, 17α-hydroxyprogesterone, progesterone, glucose, and insulin, and calculation of the free androgen index and insulin sensitivity.Result(s) The severe PCOS phenotype (hyperandrogenism, chronic anovulation, and polycystic ovaries: type I classic PCOS) was the most common phenotype in 53.9% of the patients. The phenotype of 8.9% of patients was characterized by hyperandrogenism and chronic anovulation but normal ovaries (type II classic PCOS). The two phenotypes of classic PCOS had similar clinical and endocrine characteristics, but the patients with polycystic ovaries had a higher luteinizing hormone/follicle-stimulating hormone (LH/FSH) ratio. Ovulatory PCOS was relatively common (28.8% of PCOS patients) and presented milder clinical and endocrine alterations than the classic PCOS phenotypes. The normoandrogenic phenotype was relatively uncommon. These patients had a normal body mass index, insulin sensitivity, and free androgen index but showed increased levels of LH and LH/FSH ratio.Conclusion(s) Ovulatory PCOS represents the mild form of classic PCOS, but the normoandrogenic phenotype, although part of the spectrum, may represent a different disorder or have a different pathogenetic pathway.

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Metadata

Authors
Guastella, E., Longo, R. A., & Carmina, E.
Affiliations
University of Palermo (IT)
Corresponding author
Carmina, Enrico
ORCID
Carmina, Enrico
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2010-11
Volume
94
Issue
6
Pages
2197-2201
ISSN
0015-0282 (ISSN-L)
DOI
10.1016/j.fertnstert.2010.02.014
OpenAlex
W2129451889
Cited by
205
References
23
Citations by year
2026: 10 · 2025: 12 · 2024: 14 · 2023: 13 · 2022: 15 · 2021: 22 · 2020: 6 · 2019: 5 · 2018: 9 · 2017: 11 · 2016: 16 · 2015: 15 · 2014: 9 · 2013: 16 · 2012: 19
FWCI
17.91
Type
journal article
Language
en
Open access
Licence
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
  • Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Keywords
polycystic ovary syndrome, PCOS phenotypes, hyperandrogenism, chronic anovulation, LH/FSH ratio, insulin sensitivity, free androgen index, sex hormone-binding globulin, dehydroepiandrosterone sulfate, insulin resistance, Rotterdam criteria
MeSH terms
Adult, Androgens, Endocrine System, Female, Follicle Stimulating Hormone, Humans, Luteinizing Hormone, Phenotype, Polycystic Ovary Syndrome, Retrospective Studies, Sex Hormone-Binding Globulin, Prevalence, Case-Control Studies, Hyperandrogenism, Dehydroepiandrosterone Sulfate, Young Adult

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