Use of oral contraceptives in women with endometriosis before assisted reproduction treatment improves outcomes
Open accessAbstract
In women with endometriosis, including those with endometriomas, 6 to 8 weeks of continuous use of oral contraception (OC) before assisted reproduction treatment (ART) maintains ART outcomes comparable with the outcomes of age-matched controls without endometriosis. In contrast, ART outcomes are markedly compromised in endometriosis patients who are not pretreated with OC. Ovarian responsiveness to stimulation was not altered by 6 to 8 weeks' use of pre-ART OC, including in poor responders with endometriomas.
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There is insufficient evidence to recommend prolonged administration of combined oral contraceptives (COC)/progestogens as a pre-treatment to ART to increase live birth rates.
“There is insufficient evidence to recommend prolonged administration of the combined oral contraceptives (COC)/progestogens as a pre-treatment to ART to increase live birth rates (de Ziegler et al., 2010).”
From ESHRE guideline: endometriosis (2022) · cites this paper as de Ziegler et al., 2010
Pretreatment with oral contraceptives for 6-8 weeks has been reported to improve ART outcome in endometriosis.
“Subsequently, a similar benefit of ART outcome has been reported with 6-8 weeks of pretreatment with oral contraceptives (55).”
From Endometrial receptivity in adenomyosis and/or endometriosis (2023) · cites this paper as [55]
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References 21 · Cited by 112
- Authors
- de Ziegler, D., Gayet, V., Aubriot, F. X., Fauque, P., Streuli, I., Wolf, J. P., de Mouzon, J., & Chapron, C.
- Affiliations
- Hôpital Cochin (FR)
- University of Geneva (CH)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 94
- Issue
- 7
- Pages
- 2796-2799
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2048769205
- Cited by
- 112
- References
- 21
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 10 · 2023: 7 · 2022: 9 · 2021: 4 · 2020: 6 · 2019: 9 · 2018: 9 · 2017: 10 · 2016: 3 · 2015: 7 · 2014: 9 · 2013: 12 · 2012: 10
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- endometriosis, oral contraceptives, endometrioma, ovulation induction, poor responders, ovarian response, ART outcomes
- MeSH terms
- Adult, Combined Modality Therapy, Contraceptives, Oral, Drug Administration Schedule, Endometriosis, Female, Humans, Infertility, Female, Gonadotropin-Releasing Hormone, Ovulation Induction, Pregnancy, Prognosis, Uterine Diseases, Treatment Outcome, Triptorelin Pamoate, Reproductive Techniques, Assisted
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