Aromatase inhibitors in women with clomiphene citrate resistance: a randomized, double-blind, placebo-controlled trial
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In 36 women with polycystic ovary syndrome and clomiphene citrate resistance, letrozole, an aromatase inhibitor, statistically significantly increased the ovulation rate by 33.3% in the treatment group, indicating that letrozole can be used as an effective and simple alternate ovulation-inducing agent in these women.
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One high-quality RCT with low risk of bias found letrozole better than placebo for ovulation rates (P=0.006) but similar for pregnancy rate and live birth rate per patient in women with PCOS and CCR.
“One high-quality RCT (level II) with a low risk of bias using letrozole versus placebo in PCOS with CCR, found letrozole better for ovulation rates ( P =0.006) but similar for pregnancy rate and live birth rate per patient. 243”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [243]
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References 17 · Cited by 44
- Authors
- Kamath, M. S., Aleyamma, T. K., Chandy, A., & George, K.
- Affiliations
- Christian Medical College, Vellore (IN)
- Corresponding author
- George, Korula
- ORCID
- Kamath, Mohan S.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 94
- Issue
- 7
- Pages
- 2857-2859
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2035001490
- Cited by
- 44
- References
- 17
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 1 · 2022: 5 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 5 · 2014: 2 · 2013: 1 · 2012: 5
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- aromatase inhibitors, letrozole, clomiphene citrate resistance, polycystic ovary syndrome, ovulation induction, ovulation rate, infertility treatment
- MeSH terms
- Letrozole, Adult, Clomiphene, Double-Blind Method, Drug Resistance, Female, Fertility Agents, Female, Humans, Infant, Newborn, Infertility, Female, Nitriles, Ovulation, Pregnancy, Triazoles, Treatment Failure, Pregnancy Rate, Aromatase Inhibitors, Young Adult
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