Overexpression of nerve growth factor in peritoneal fluid from women with endometriosis may promote neurite outgrowth in endometriotic lesions
Open accessAbstract
To investigate the role of the nerve growth factor (NGF) in the endometriosis-associated innervation in the development of endometriosis-associated symptoms, 41 peritoneal fluid samples (PF) from patients with surgically and histologically proven endometriosis and 20 PF from patients with other gynecologic conditions were analyzed with Western blot and a novel in vitro model using dorsal root ganglia (DRG) to show neuronal outgrowth; endometrial cells also were analyzed. The results suggest that the PF of endometriosis patients and endometriotic lesions have neurotropic properties, because the Western blot analysis and the cell culture stainings showed NGF expression, and the neurite outgrowth of DRG treated with PF of patients with endometriosis was significantly higher than when treated with PF of patients without endometriosis. Furthermore, blocking NGF with both anti-NGF and K252a leads to a significant decrease in neurite outgrowth.
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Increased density of sensory nerves in or around DE lesions results from neurotrophic factors secreted by endometriotic lesions or platelets.
“Moreover, the increased density of sensory nerves in or around DE lesions also results from neurotrophic factors secreted by endometriotic lesions84,87–90 or platelets84.”
From Neuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis (2019) · cites this paper as [88]
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References 23 · Cited by 89
- Authors
- Barcena de Arellano, M. L., Arnold, J., Vercellino, F., Chiantera, V., Schneider, A., & Mechsner, S.
- Affiliations
- Stiftung Charité (DE)
- Corresponding author
- Mechsner, Sylvia
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 95
- Issue
- 3
- Pages
- 1123-1126
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2005693586
- Cited by
- 89
- References
- 23
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 6 · 2019: 7 · 2018: 4 · 2017: 12 · 2016: 8 · 2015: 5 · 2014: 8 · 2013: 6 · 2012: 8
- FWCI
- 7.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi del Molise (submittedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
- Funders
- Bayer Schering
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Plant and fungal interactions
- Keywords
- nerve growth factor, endometriosis, peritoneal fluid, neurite outgrowth, dorsal root ganglia, endometriotic lesions, K252a, neurotropism, endometrial cells
- MeSH terms
- Animals, Ascitic Fluid, Cells, Cultured, Chick Embryo, Dysmenorrhea, Endometriosis, Endometrium, Female, Fluorescent Antibody Technique, Ganglia, Spinal, Humans, Sensory Receptor Cells, Blotting, Western, Neurites, Pelvic Pain, Nerve Growth Factor
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