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Cited by 33Sperm and Testicular FunctionReproductive Health and TechnologiesReproductive Biology and Fertility

Is intracytoplasmic morphologically selected sperm injection effective in patients with infertility related to teratozoospermia or repeated implantation failure?

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El Khattabi, Laïla, Dupont, Charlotte, Sermondade, Nathalie, Hugues, Jean-Noël, Poncelet, Christophe, Porcher, Raphael, Cedrin-Durnerin, Isabelle, Lévy, Rachel +1 more·2013·Fertility and Sterility
DOI 10.1016/j.fertnstert.2013.02.048
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Abstract

Objective To evaluate the potential benefit of intracytoplasmic morphologically selected sperm injection (IMSI) in patients selected for either severe teratozoospermia or repeated implantation failure after conventional intracytoplasmic sperm injection (ICSI). Design Prospective nonrandomized observational study. Setting University hospital assisted reproduction unit. Patient(s) Four hundred seventy-eight patients were enrolled to evaluate ICSI and IMSI results for two indications. The first group (T) was composed of patients with severe teratozoospermia (<10% normal spermatozoa in fresh ejaculated and selected semen, according to David classification) and no or one previous ICSI failure. In the second group (IF), patients with at least two previous failed ICSI attempts were enrolled in absence of severe male factor (>10% normal spermatozoa in fresh ejaculated semen and >20% in selected sperm). Intervention(s) ICSI/IMSI, biologic, and clinical data collection. Main outcome measure(s) Live-birth rate (LBR). Result(s) In group T, LBR was significantly higher when IMSI procedure was used compared with ICSI (38% [50/132] vs. 20% [25/126]). However, LBR observed in group IF was not significantly different between IMSI and ICSI procedures (21% [19/90] vs. 22% [28/130]). Conclusion(s) IMSI procedure is a valuable option for patients with severe teratozoospermia at their first or second attempts, but it does not improve pregnancy rate in patients with repeated ICSI failures in the absence of severe male factor.

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  • ART, particularly ICSI, is often recommended in men with severe teratozoospermia.

    “Hence, assisted reproductive technology (ART), particularly intracytoplasmic sperm injection (ICSI), are often recommended in men with severe teratozoospermia (16,17).”

    From Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review (2024) · cites this paper as [17]

    The Study Groups section reports that patients with severe teratozoospermia underwent ICSI or IMSI, supporting the use of these ART procedures in that group. But the Semen Evaluation and Preparation section lists other common indications for ICSI, and the paper does not say that ICSI is often recommended specifically for severe teratozoospermia. Its Discussion instead suggests IMSI may benefit those patients. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • A very limited number of review articles specifically address isolated teratozoospermia.

    “Despite the huge increase in the literature on male infertility, a very limited number of review articles specifically address isolated teratozoospermia (17,21).”

    From Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review (2024) · cites this paper as [17]

    The References list a systematic review on isolated teratozoospermia, but the paper does not assess how many review articles address the topic. The Discussion calls this the first study of a specific IMSI approach in these patients; that does not establish the claimed scarcity of reviews. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

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Cites

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Research works printed but not linked: 34

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Authors
El Khattabi, L., Dupont, C., Sermondade, N., Hugues, J.-N., Poncelet, C., Porcher, R., Cedrin-Durnerin, I., Lévy, R., & Sifer, C.
Affiliations
  • Inserm (FR)
  • Assistance Publique – Hôpitaux de Paris (FR)
Corresponding author
Sifer, Christophe
ORCID
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2013-07
Volume
100
Issue
1
Pages
62-68
ISSN
0015-0282 (ISSN-L)
DOI
10.1016/j.fertnstert.2013.02.048
OpenAlex
W2001250941
Cited by
33
References
1
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 6 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 7 · 2013: 2
FWCI
6.06
Type
journal article
Language
en
Open access
Licence
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords
intracytoplasmic morphologically selected sperm injection, IMSI, intracytoplasmic sperm injection, teratozoospermia, male infertility, recurrent implantation failure, live birth rate, sperm morphology, assisted reproduction outcomes
MeSH terms
Adult, Female, Humans, Infertility, Male, Male, Pregnancy, Prospective Studies, Treatment Outcome, Treatment Failure, Pregnancy Rate, Sperm Injections, Intracytoplasmic, Azoospermia

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