Polycystic ovary syndrome is a risk factor for diabetes and prediabetes in middle-aged but not elderly women: a long-term population-based follow-up study
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Objective To study the incidence rate and hazard ratios of diabetes and prediabetes between women with PCOS and healthy subjects.Design Prospective population-based study.Setting Not applicable.Patient(s) Women with PCOS (n = 178) and eumenorrheic, nonhirsute, healthy women as controls (n = 1,524), all followed for a median time of 12.9 years.Intervention(s) None.Main outcome measure(s) Incidence rate and hazard ratios of diabetes and prediabetes between women with PCOS and healthy controls.Result(s) We analyzed the participants on two pathways. First, for detecting new diabetes mellitus (DM) events, we selected participants who were free of DM at baseline (n = 39). Second, for detecting new pre-DM events, we selected participants who were free of pre-DM and DM at baseline (n = 222) from the baseline population. The rest of the population were included for final analysis to calculate the incidence rates and hazard ratio of diabetes and prediabetes events. The incidence rates of diabetes were 12.9 and 4.9 per 1,000 person-years for PCOS and controls, respectively. This incidence rate in women younger than 40 with and without PCOS was 13.4 and 4.2, respectively. The adjusted hazard ratio (HR) for women ≤40 was 4.9 (95% confidence interval [CI], 2.5-9.3). There were no statistically significant differences between the two groups studied after age 40. The incidence rates of prediabetes were 29.7 and 25.9 per 1,000 person-years for PCOS and healthy women, respectively. The incidence rate in women younger than 40 with and without PCOS was 30.3 and 23.9, respectively. The adjusted HR for women ≤40 years, 1.7 (95% CI, 1.1-2.6), disappeared after age 40.Conclusion(s) These data suggest that routine screening for diabetes in prevention strategies does not need to be emphasized for PCOS patients at late reproductive ages if they have not been affected by glucose intolerance up to that point.
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In another cohort of women with PCOS followed for a median of 13 years, there was no difference in hazard ratio for T2DM above 40 years compared to controls.
“In another cohort of women with PCOS followed for a median of 13 years, there was no difference in hazard ratio for T2DM above 40 years, as compared to controls (Kazemi Jaliseh et al., 2017).”
From Type 2 diabetes mellitus in women with polycystic ovary syndrome during a 24-year period: importance of obesity and abdominal fat distribution (2020) · cites this paper as Kazemi Jaliseh et al., 2017
The results regarding prevalence of T2DM in women with PCOS over the age of 40 years are conflicting.
“The results regarding prevalence of T2DM in women with PCOS over the age of 40 years are conflicting.”
From Type 2 diabetes mellitus in women with polycystic ovary syndrome during a 24-year period: importance of obesity and abdominal fat distribution (2020) · cites this paper as Kazemi Jaliseh et al., 2017
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References 42 · Cited by 80
- Authors
- Kazemi Jaliseh, H., Ramezani Tehrani, F., Behboudi-Gandevani, S., Hosseinpanah, F., Khalili, D., Cheraghi, L., & Azizi, F.
- Affiliations
- Research Institute for Endocrine Sciences (IR)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 108
- Issue
- 6
- Pages
- 1078-1084
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2772478311
- Cited by
- 80
- References
- 42
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 3 · 2023: 11 · 2022: 11 · 2021: 20 · 2020: 10 · 2019: 8 · 2018: 7 · 2017: 1
- FWCI
- 8.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Keywords
- polycystic ovary syndrome, diabetes mellitus, prediabetes, diabetes incidence, middle-aged women, older women, age-related risk, diabetes screening, impaired glucose tolerance, reproductive age
- MeSH terms
- Adolescent, Adult, Age Factors, Diabetes Mellitus, Female, Follow-Up Studies, Humans, Iran, Middle Aged, Polycystic Ovary Syndrome, Prediabetic State, Prognosis, Prospective Studies, Risk Factors, Time Factors, Incidence, Proportional Hazards Models, Case-Control Studies, Risk Assessment, Kaplan-Meier Estimate, Young Adult
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