Are combined hormonal contraceptives the neglected treatment for symptomatic endometriosis?
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One-third of women with endometriosis do not respond to OCPs or progestogens because of progesterone resistance.
“in one-third of women due to progesterone resistance”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [62]
OCPs can play an important role in the management of endometriosis, as two-thirds of women with symptomatic endometriosis respond to estroprogestins.
“these authors concluded that OCPs can play an important role in the management of endometriosis, as two-thirds of women with symptomatic endometriosis respond to estroprogestins.”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [62]
OCPs have no beneficial effect on non-menstrual pelvic pain and dyspareunia.
“There was, however, a lack of any beneficial effect of OCPs on non-menstrual pelvic pain and dyspareunia”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [62]
33% of patients given estroprogestins and/or progestins do not respond to therapy.
“33% of patients given estroprogestins and/or progestins do not respond to therapy.”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [62]
The risk of venous or arterial thrombosis with OCPs is not negligible.
“the risk of venous or arterial thrombosis is not negligible [54,55,56,57,58,59,60,61,62,63,64,65,66,67].”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [62]
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References 5 · Cited by 20
- Authors
- Vercellini, P.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Vercellini, Paolo
- ORCID
- Vercellini, Paolo
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 110
- Issue
- 1
- Pages
- 61-62
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2807847822
- Cited by
- 20
- References
- 5
- Citations by year
- 2026: 2 · 2024: 5 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 1
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- combined hormonal contraceptives, endometriosis treatment, hormone therapy
- MeSH terms
- Contraceptives, Oral, Hormonal, Endometriosis, Female, Humans, Pelvic Pain
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