Human neutrophils dump Candida glabrata after intracellular killing
Abstract
Interaction between fungal pathogens and human phagocytes can lead to remarkably variable outcomes, ranging from intracellular killing to prolonged survival and replication of the pathogen in the host cell. Using live cell imaging we observed primary human neutrophils that release phagocytosed Candida glabrata yeast cells after intracellular killing. This process, for which we propose the name "dumping", adds a new outcome to phagocyte-fungus interaction which may be of potential immunological importance as it allows professional antigen presenting cells to take up and process neutrophil-inactivated pathogens that in their viable state are able to evade intracellular degradation in these cells.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Human neutrophils, after phagocytosis, killed and dumped C. glabrata.
“Additionally, human neutrophils, after phagocytosis, killed and dumped C. glabrata, which may aid in activation of the immune response [142].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [142]
The citation lists haven’t been fetched yet
References 22 · Cited by 20
- Authors
- Essig, F., Hünniger, K., Dietrich, S., Figge, M. T., & Kurzai, O.
- Affiliations
- Jena University Hospital (DE)
- Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) (DE)
- Corresponding author
- Kurzai, Oliver
- Venue
- Fungal Genetics and Biology
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 84
- Pages
- 37-40
- ISSN
- 1087-1845 (ISSN-L)
- OpenAlex
- W1745417345
- Cited by
- 20
- References
- 22
- Citations by year
- 2026: 1 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 1
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Fungal Genetics and Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Candida glabrata, neutrophils, phagocytosis, intracellular killing, dumping, antigen presentation, live-cell imaging
- MeSH terms
- Cells, Cultured, Cytoplasm, Humans, Neutrophils, Phagocytosis, Candida glabrata, Adaptive Immunity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
