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Toxicity of raw and processed roots of Polygonum multiflorum
Abstract
The roots of Polygonum multiflorum (Chinese name: He-Shou-Wu, HSW) are used in traditional Chinese medicine for many diseases in processed form or raw state. There are reports dealing with the toxicity of HSW. However, the toxicity is caused by over dosage or by the herb itself remains unclear. We evaluated the toxicity of raw and processed HSW on Kunming (KM) mice. For raw HSW, the toxicity of water decocta is much higher than that of acetone extract. Meanwhile, the toxicity of acetone extract of raw HSW is considerably higher than that of acetone extract of processed HSW. HPLC analyses revealed that the contents of characteristic compounds in raw HSW were changed after processing: the content of 2,3,4',5-tetrahydroxystilbene 2-O-β-D-glucoside was decreased by 55.8%, whereas the content of emodin was increased by 34.0%. Thus, processing could reduce the toxicity of HSW. Thus, the toxicity of HSW does not depend on the content of anthranoid derivatives, it may be correlated with the content of tetrahydroxystilbene glucosides.
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Laboratory studies have shown that natural medicines such as Heshouwu, Leigongteng, or Xiao-Chai-Hu-Tang cause immune activation, metabolic disorders, apoptosis and damage to liver cells.
“although laboratory studies have also shown that these treatments cause immune activation, metabolic disorders, apoptosis and damage to liver cells.[35][36][37][38][39]”
From Incidence and Etiology of Drug-Induced Liver Injury in Mainland China (2019) · cites this paper as [37]
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Incidence and Etiology of Drug-Induced Liver Injury in Mainland China
Shen, T., Liu, Y., Shang, J., Xie, Q., Li, J., Yan, M., Xu, J., Niu, J., Liu, J., Watkins, P. B., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.02.002 · Cited by 615
Islam, R., Mamat, Y., Ismayil, I., Yan, M., Kadir, M., Abdugheny, A., Rapkat, H., Niyaz, M., Ali, Y., & Abay, S. (2015) · Phytotherapy Research · doi:10.1002/ptr.5317 · Cited by 19
Metadata
- Authors
- Wu, X., Chen, X., Huang, Q., Fang, D., Li, G., & Zhang, G.
- Venue
- Fitoterapia
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 83
- Issue
- 3
- Pages
- 469-475
- ISSN
- 0367-326X
- Cited by
- 98
- References
- 0
- Language
- en
- Funders
- National Basic Research Program of China (2009CB522804)
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