CoChat
Sign Up
Cited by 173

The DOI matches its Crossref record.

Chitosan-coated liposomes as delivery systems for improving the stability and oral bioavailability of acteoside

Zhou, Fei, Xu, Tao, Zhao, Yajing, Song, Huaxin, Zhang, Liuquan, Wu, Xiaodan, Lu, Baiyi·2018·Food Hydrocolloids
DOI 10.1016/j.foodhyd.2018.04.040
Open this paper in CoChat — free account

Abstract

The stability and bioavailability of acteoside were improved by encapsulating it with liposomes and chitosan. The liposomes were characterized through transmission electron microscopy, differential scanning calorimetry and Fourier transform infrared spectroscopy, and their particle size, zeta potential, encapsulation efficiency (EE), in vitro release, storage stability and oral bioavailability were tested. Results showed that the particles were nanosized and spherical. The average diameter, zeta potential, EE and relative bioavailability (Fᵣₑₗ) of the acteoside liposome (Ac-Lip) were 78.49 ± 1.44 nm, −4.93 ± 0.79 mV, 81.06 ± 3.48% and 217.62%, respectively. These parameters increased to 92.77 ± 2.99 nm, +19.65 ± 0.90 mV, 88.10 ± 5.36% and 442.84%, respectively, after the surface of Ac-Lip was coated with 2 mg/mL of chitosan (CS-Ac-Lip). In contrast to Ac-Lip, the CS-Ac-Lip showed a reduced in vivo release rate and enhanced storage stability. The chitosan coating increased the diameter, zeta potential, EE, in vivo release time, stability and bioavailability of the Ac-Lip, and the chitosan–liposome is a promising delivery system for transporting acteoside or other bioactive components.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.foodhyd.2018.04.040

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 27

  1. Alipieva, 2014, Verbascoside-a review of its occurrence, (bio)synthesis and pharmacological significance, Biotechnology Advances, 32, 1065, 10.1016/j.biotechadv.2014.07.001 · DOI
  2. Caddeo, 2016, Cross-linked chitosan/liposome hybrid system for the intestinal delivery of quercetin, Journal of Colloid and Interface Science, 461, 69, 10.1016/j.jcis.2015.09.013 · DOI
  3. Calis, 1999, Phenylethanoid glycosides from Globularia trichosantha, Journal of Natural Products, 62, 1165, 10.1021/np9900526 · DOI
  4. Cardinali, 2011, Verbascosides from olive mill waste water: Assessment of their bioaccessibility and intestinal uptake using an in vitro digestion/Caco-2 model system, Journal of Food Science, 76, 48, 10.1111/j.1750-3841.2010.01996.x · DOI
  5. Cardinali, 2013, Assessment of verbascoside absorption in human colonic tissues using the Ussing chamber model, Food Research International, 54, 132, 10.1016/j.foodres.2013.06.017 · DOI
  6. Chen, 2015, The stability, sustained release and cellular antioxidant activity of curcumin nanoliposomes, Molecules, 20, 14293, 10.3390/molecules200814293 · DOI
  7. Hao, 2017, Encapsulation of the flavonoid quercetin with chitosan-coated nano-liposomes, LWT - Food Science and Technology, 85, 37, 10.1016/j.lwt.2017.06.048 · DOI
  8. Hasan, 2016, Chitosan-coated liposomes encapsulating curcumin: Study of lipid–polysaccharide interactions and nanovesicle behavior, RSC Advances, 6, 45290, 10.1039/C6RA05574E · DOI
  9. Isacchi, 2017, Liposomal formulation to increase stability and prolong antineuropathic activity of verbascoside, Planta Medica, 83, 412
  10. Karewicz, 2013, Curcumin-containing liposomes stabilized by thin layers of chitosan derivatives, Colloids and Surfaces B: Biointerfaces, 109, 307, 10.1016/j.colsurfb.2013.03.059 · DOI
  11. Li, 2017, Liposomes coated with thiolated chitosan as drug carriers of curcumin, Materials Science and Engineering: C, 80, 156
  12. Liu, 2013, Improved physical and in vitro digestion stability of a polyelectrolyte delivery system based on layer-by-layer self-assembly alginate–chitosan-coated nanoliposomes, Journal of Agricultural and Food Chemistry, 61, 4133, 10.1021/jf305329n · DOI
  13. Liu, 2016, Environmental stress stability of microencapsules based on liposomes decorated with chitosan and sodium alginate, Food Chemistry, 196, 396, 10.1016/j.foodchem.2015.09.050 · DOI
  14. Liu, 2015, Temperature-dependent structure stability and in vitro release of chitosan-coated curcumin liposome, Food Research International, 74, 97, 10.1016/j.foodres.2015.04.024 · DOI
  15. Lopes, 2017, Pectin and polygalacturonic acid-coated liposomes as novel delivery system for nisin: Preparation, characterization and release behavior, Food Hydrocolloids, 70, 1, 10.1016/j.foodhyd.2017.03.016 · DOI
  16. Panossian, 2010, Rosenroot (Rhodiola rosea): Traditional use, chemical composition, pharmacology and clinical efficacy, Phytomedicine, 17, 481, 10.1016/j.phymed.2010.02.002 · DOI
  17. Peng, 2017, Hybrid liposomes composed of amphiphilic chitosan and phospholipid: Preparation, stability and bioavailability as a Carrier for curcumin, Carbohydrate Polymers, 156, 322, 10.1016/j.carbpol.2016.09.060 · DOI
  18. Rafiee, 2017, Nanoliposomal carriers for improvement the bioavailability of high-valued phenolic compounds of pistachio green hull extract, Food Chemistry, 220, 115, 10.1016/j.foodchem.2016.09.207 · DOI
  19. Ren, 2017, Influence of chitosan concentration on mechanical and barrier properties of corn starch/chitosan films, International Journal of Biological Macromolecules, 105, 1636, 10.1016/j.ijbiomac.2017.02.008 · DOI
  20. Ruttala, 2017, Multiple polysaccharide-drug complex-loaded liposomes: A unique strategy in drug loading and cancer targeting, Carbohydrate Polymers, 173, 57, 10.1016/j.carbpol.2017.05.062 · DOI
  21. Sheng, 2002, Protective effect of verbascoside on 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells, European Journal of Pharmacology, 451, 119, 10.1016/S0014-2999(02)02240-9 · DOI
  22. Wang, 2017, Chitosan-modified cholesterol-free liposomes for improving the oral bioavailability of progesterone, Colloids and Surfaces B: Biointerfaces, 159, 580
  23. Wang, 2017, Ursolic acid liposomes with chitosan modification: Promising antitumor drug delivery and efficacy, Materials Science and Engineering: C, 71, 1231
  24. Wu, 2006, Determination of acteoside in Cistanche deserticola and Boschniakia rossica and its pharmacokinetics in freely-moving rats using LC–MS/MS, Journal of Chromatography B, 844, 89, 10.1016/j.jchromb.2006.07.011 · DOI
  25. Zhao, 2015, Self-assembly and cytotoxicity study of PEG-modified ursolic acid liposomes, Materials Science and Engineering: C, 53, 196
  26. Zhou, 2017, Varietal classification and antioxidant activity prediction of Osmanthus fragrans Lour. flowers using UPLC–PDA/QTOF–MS and multivariable analysis, Food Chemistry, 217, 490, 10.1016/j.foodchem.2016.08.125 · DOI
  27. Zhou, 2017, Degradation of phenylethanoid glycosides in Osmanthus fragrans Lour. flowers and its effect on anti-hypoxia activity, Scientific Reports, 7, 10068, 10.1038/s41598-017-10411-0 · DOI

Cited by

Sorted by citations

See all 173

Metadata

Authors
Zhou, F., Xu, T., Zhao, Y., Song, H., Zhang, L., Wu, X., & Lu, B.
Venue
Food Hydrocolloids
Publisher
Elsevier BV
Published
2018-10
Volume
83
Pages
17-24
ISSN
0268-005X
DOI
10.1016/j.foodhyd.2018.04.040
Cited by
173
References
0
Language
en
Licence
Funders
  • Zhejiang Provincial Natural Science Foundation of China (R15C200002)
  • National Major R & D Program of China (2017YFD0400200)
  • Fundamental Research Funds for the Central Universities of China
  • Special Project of Agricultural Product Quality Safety Risk Assessment (GJFP2018015)
  • Ministry of Agriculture, China

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Chitosan-coated liposomes as delivery systems for improving the stability and oral bioavailability of acteoside. https://app.cochat.ai/papers/10.1016/j.foodhyd.2018.04.040
The paper
Zhou, F., Xu, T., Zhao, Y., Song, H., Zhang, L., Wu, X., & Lu, B. (2018). Chitosan-coated liposomes as delivery systems for improving the stability and oral bioavailability of acteoside. Food Hydrocolloids. https://doi.org/10.1016/j.foodhyd.2018.04.040