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Pathology of peliosis
Abstract
Peliosis is a pathological entity characterized by the gross appearance of multiple cyst-like, blood-filled cavities within parenchymatous organs. Peliosis has been related to several underlying debilitating illnesses such as tuberculosis, hematological malignancies, the acquired immunodeficiency syndrome (AIDS), and post-transplant immunodeficiency, as well as intravenous drug abuse, chronic alcoholism, and in conjunction with the intake of oral contraceptives or steroids. The classical pathoanatomical concept is based upon the opinion that peliosis exclusively develops in organs belonging to the mononuclear phagocytic system (liver, spleen, bone marrow, and lymph nodes). However, a paucity of studies indicates that other organs such as lungs, parathyroid glands, and kidneys may be affected too. Concerning the underlying pathogenetic mechanisms of onset and maintenance of peliosis, the morphological data obtained by different investigators suggest that there is more than one path of formal pathogenesis (e.g., congenital malformation of vessels manifesting under altered local intravascular pressure conditions, acquired vascular disorder triggered by toxic noxae, active proliferation of vessels corresponding to the benign end on the spectrum of neoplastic vascular lesions). In the liver, at gross inspection, the peliotic lesions give the cut sections a "swiss cheese" appearance. Microscopically, two different types of peliosis can be distinguished in the liver: (1) "parenchyma…
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“Clinically, some cases with chronic DILI develop from the chronicity of acute DILI, however, some might be a specific phenotype caused by drugs (e.g., drug-associated fatty liver disease [75], druginduced fibrosis/cirrhosis, nodular regenerative hyperplasia [76], drug-induced autoimmune-like hepatitis [DI-ALH], and peliosis hepatis [77]).”
From Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update (2024) · cites this paper as [77]
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Cited by
Sorted by citations
Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update
Mao, Y., Ma, S., Liu, C., Liu, X., Su, M., Li, D., Li, Y., Chen, G., Chen, J., Chen, J., et al. (2024) · Hepatology International · doi:10.1007/s12072-023-10633-7 · Cited by 62
Metadata
- Authors
- Tsokos, M., & Erbersdobler, A.
- Venue
- Forensic Science International
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 149
- Issue
- 1
- Pages
- 25-33
- ISSN
- 0379-0738
- Cited by
- 163
- References
- 0
- Language
- en
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