Cited by 281Heme Oxygenase-1 and Carbon MonoxideHemoglobin structure and functionRedox biology and oxidative stress

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Carbon monoxide, reactive oxygen signaling, and oxidative stress

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Piantadosi, Claude A.·2008·Free Radical Biology and Medicine

DOI 10.1016/j.freeradbiomed.2008.05.013PMC PMC2570053

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Abstract

The ubiquitous gas, carbon monoxide (CO), is of substantial biological importance, but apart from its affinity for reduced transition metals, particularly heme-iron, it is surprisingly nonreactive-as is the ferrous-carbonyl-in living systems. CO does form strong complexes with heme proteins for which molecular O2 is the preferred ligand and to which are attributed diverse physiological, adaptive, and toxic effects. Lately, it has become apparent that both exogenous and endogenous CO produced by heme oxygenase engender a prooxidant milieu in aerobic mammalian cells which initiates signaling related to reactive oxygen species (ROS) generation. ROS signaling contingent on CO can be segregated by CO concentration-time effects on cellular function, by the location of heme proteins, e.g., mitochondrial or nonmitochondrial sites, or by specific oxidation-reduction (redox) reactions. The fundamental responses to CO involve overt physiological regulatory events, such as activation of redox-sensitive transcription factors or stress-activated kinases, which institute compensatory expression of antioxidant enzymes and other adaptations to oxidative stress. In contrast, responses originating from highly elevated or protracted CO exposures tend to be nonspecific, produce untoward biological oxidations, and interfere with homeostasis. This brief overview provides a conceptual framework for understanding CO biology in terms of this physiological-pathological hierarchy.

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Suliman, H. B., Carraway, M. S., Ali, A. S., Reynolds, C. M., Welty‐Wolf, K. E., & Piantadosi, C. A. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32967 · Cited by 261
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Suliman, H. B., Carraway, M. S., Tatro, L. G., & Piantadosi, C. A. (2006) · Journal of Cell Science · doi:10.1242/jcs.03318 · Cited by 213
Self-citation
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Carbon Monoxide Protects against Hyperoxia-induced Endothelial Cell Apoptosis by Inhibiting Reactive Oxygen Species Formation
Wang, X., Wang, Y., Kim, H. P., Nakahira, K., Ryter, S. W., & Choi, A. M. K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607610200 · Cited by 192
Retracted
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139
THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases
Maines, M. D. (1997) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.37.1.517 · Cited by 2,489
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
Otterbein, L. E., Bach, F. H., Alam, J., Soares, M., Tao Lu, H., Wysk, M., Davis, R. J., Flavell, R. A., & Choi, A. M. K. (2000) · Nature Medicine · doi:10.1038/74680 · Cited by 2,153
Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia
Chandel, N. S., McClintock, D. S., Feliciano, C. E., Wood, T. M., Melendez, J. A., Rodriguez, A. M., & Schumacker, P. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001914200 · Cited by 2,000
Carbon Monoxide: a Putative Neural Messenger
Verma, A. M., Hirsch, D. B., Glatt, C. E., Ronnett, G. V., & Snyder, S. H. (1993) · Science · doi:10.1126/science.7678352 · Cited by 1,563
Microsomal Heme Oxygenase
Tenhunen, R., Marver, H. S., & Schmid, R. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63477-5 · Cited by 1,357
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
Kelly, D. P., & Scarpulla, R. C. (2004) · Genes & Development · doi:10.1101/gad.1177604 · Cited by 1,243
Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide
Nisoli, E., Clementi, E., Paolucci, C., Cozzi, V., Tonello, C., Sciorati, C., Bracale, R., Valerio, A., Francolini, M., Moncada, S., et al. (2003) · Science · doi:10.1126/science.1079368 · Cited by 1,243
Reversible Inactivation of the Tumor Suppressor PTEN by H2O2
Lee, S.-R., Yang, K., Kwon, J., Lee, C., Jeong, W., & Rhee, S. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111899200 · Cited by 1,061
Carbon Monoxide Generated by Heme Oxygenase 1 Suppresses Endothelial Cell Apoptosis
Brouard, S., Otterbein, L. E., Anrather, J., Tobiasch, E., Bach, F. H., Choi, A. M. K., & Soares, M. P. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1015 · Cited by 984
The heme synthesis and degradation pathways: role in oxidant sensitivity
Ryter, S. W., & Tyrrell, R. M. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00223-3 · Cited by 825
Activation of the human mitochondrial transcriptionfactor A gene by nuclear respiratory factors: a potential regulatory linkbetween nuclear and mitochondrial gene expression in organellebiogenesis.
Virbasius, J. V., & Scarpulla, R. C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.4.1309 · Cited by 819
Redox regulation of PI 3‐kinase signalling via inactivation of PTEN
Leslie, N. R., Bennett, D., Lindsay, Y. E., Stewart, H., Gray, A., & Downes, C. P. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg513 · Cited by 631
The protonmotive Q cycle. Energy transduction by coupling of proton translocation to electron transfer by the cytochrome bc1 complex.
Trumpower, B. L. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38410-8 · Cited by 598
Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria
Pamplona, A., Ferreira, A., Balla, J., Jeney, V., Balla, G., Epiphanio, S., Chora, Â., Rodrigues, C. D., Gregoire, I. P., Cunha-Rodrigues, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1586 · Cited by 560
Haem oxygenase-1 prevents cell death by regulating cellular iron
Ferris, C. D., Jaffrey, S. R., Sawa, A., Takahashi, M., Brady, S. D., Barrow, R. K., Tysoe, S. A., Wolosker, H., Barañano, D. E., Doré, S., et al. (1999) · Nature Cell Biology · doi:10.1038/11072 · Cited by 513
Regulation of Nox and Duox enzymatic activity and expression
Lambeth, J. D., Kawahara, T., & Diebold, B. A. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.028 · Cited by 510
Nitric oxide and iron proteins
Cooper, C. E. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00021-3 · Cited by 510
Mechanism of p38 MAP kinase activation in vivoPreprint
Brancho, D., Tanaka, N., Jaeschke, A., Ventura, J., Kelkar, N., Tanaka, Y., Kyuuma, M., Takeshita, T., Flavell, R. A., & Davis, R. J. (2003) · Genes & Development · doi:10.1101/gad.1107303 · Cited by 490
Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase.
Brüne, B., & Ullrich, V. (1987) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13029-0 · Cited by 472
Endothelium-Dependent and -Independent Vasodilation Involving Cyclic GMP: Relaxation Induced by Nitric Oxide, Carbon Monoxide and Light
Furchgott, R. F., & Jothianandan, D. (2008) · Blood Vessels · doi:10.1159/000158843 · Cited by 471
Heme Oxygenase-1 Modulates the Expression of Adhesion Molecules Associated with Endothelial Cell Activation
Soares, M. P., Seldon, M. P., Grégoire, I. P., Vassilevskaia, T. D., Berberat, P. O., Yu, J. H., Tsui, T., & Bach, F. H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.6.3553 · Cited by 464
Hemoxygenase-2 Is an Oxygen Sensor for a Calcium-Sensitive Potassium Channel
Williams, S. E. J., Wootton, P., Mason, H. S., Bould, J., Iles, D., Riccardi, D., Peers, C., & Kemp, P. J. (2004) · Science · doi:10.1126/science.1105010 · Cited by 458
Biochemical Characterization and Ligand Binding Properties of Neuroglobin, a Novel Member of the Globin Family
Dewilde, S., Kiger, L., Burmester, T., Hankeln, T., Baudin‐Creuza, V., Aerts, T., Marden, M. C., Caubergs, R. J., & Moens, L. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106438200 · Cited by 453
NPAS2: A Gas-Responsive Transcription Factor
Dioum, E. M., Rutter, J. P., Tuckerman, J. R., Gonzalez, G., Gilles‐Gonzalez, M., & McKnight, S. L. (2002) · Science · doi:10.1126/science.1078456 · Cited by 432
Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis
Fujita, T., Toda, K., Karimova, A., Yan, S., Naka, Y., Yet, S., & Pinsky, D. J. (2001) · Nature Medicine · doi:10.1038/87929 · Cited by 399
Suppression of Inflammatory Cytokine Production by Carbon Monoxide Involves the JNK Pathway and AP-1
Morse, D., Pischke, S. E., Zhou, Z., Davis, R. J., Flavell, R. A., Loop, T., Otterbein, S. L., Otterbein, L. E., & Choi, A. M. K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302942200 · Cited by 373
Heme Oxygenase-1 Modulates Early Inflammatory Responses
Kapturczak, M. H., Wasserfall, C., Brusko, T., Campbell-Thompson, M., Ellis, T. M., Atkinson, M. A., & Agarwal, A. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63365-2 · Cited by 370
Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts
Nakahira, K., Kim, H. P., Geng, X. H., Nakao, A., Wang, X., Murase, N., Drain, P. F., Wang, X., Sasidhar, M., Nabel, E. G., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060845 · Cited by 362
Heme oxygenase and the cardiovascular–renal system
Abraham, N. G., & Kappas, A. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.03.010 · Cited by 356
Carbon Monoxide Controls the Proliferation of Hypoxic Vascular Smooth Muscle Cells
Morita, T., Mitsialis, S. A., Koike, H., Liu, Y., & Kourembanas, S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.32804 · Cited by 332
Nitric Oxide Induces Heme Oxygenase-1 Gene Expression and Carbon Monoxide Production in Vascular Smooth Muscle Cells
Durante, W., Kroll, M. H., Christodoulides, N., Peyton, K. J., & Schafer, A. I. (1997) · Circulation Research · doi:10.1161/01.res.80.4.557 · Cited by 329
Heme-based sensors: defining characteristics, recent developments, and regulatory hypotheses
Gilles‐Gonzalez, M., & GONZALEZ, G. (2004) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2004.11.006 · Cited by 328
Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species
Zuckerbraun, B. S., Chin, B. Y., Bilban, M., d'Avila, J. D. C., Rao, J., Billiar, T. R., & Otterbein, L. E. (2007) · The FASEB Journal · doi:10.1096/fj.06-6644com · Cited by 323
Mitochondrial oxidative stress after carbon monoxide hypoxia in the rat brain.
Zhang, J., & Piantadosi, C. A. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115980 · Cited by 320
Self-citation
E2F1 and c-Myc Potentiate Apoptosis through Inhibition of NF-κB Activity that Facilitates MnSOD-Mediated ROS Elimination
Tanaka, H., Matsumura, I., Ezoe, S., Satoh, Y., Sakamaki, T., Albanese, C., Machii, T., Pestell, R. G., & Kanakura, Y. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00522-1 · Cited by 289
Inhibition of Hypoxia-inducible Factor 1 Activation by Carbon Monoxide and Nitric Oxide
Huang, E. L., Willmore, W. G., Gu, J., Goldberg, M. A., & Bunn, H. F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.9038 · Cited by 288
Heme oxygenase–carbon monoxide signalling pathway in atherosclerosis: anti-atherogenic actions of bilirubin and carbon monoxide?
Siow, R. C. M. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00278-8 · Cited by 274
The heme oxygenase pathway and its interaction with nitric oxide in the control of cellular homeostasis
Foresti, R., & Motterlini, R. (1999) · Free Radical Research · doi:10.1080/10715769900301031 · Cited by 271
The Stoichiometry and Absorption Spectra of Components a and a3 in Cytochrome c Oxidase*
Vanneste, W. H. (1966) · Biochemistry · doi:10.1021/bi00867a005 · Cited by 265
The Drosophila Nuclear Receptor E75 Contains Heme and Is Gas Responsive
Reinking, J., Lam, M. M. S., Pardee, K., Sampson, H. M., Liu, S., Yang, P., Williams, S. P., White, W. L., Lajoie, G., Edwards, A. M., et al. (2005) · Cell · doi:10.1016/j.cell.2005.07.005 · Cited by 260
Mitochondrial Transcription Factor A Induction by Redox Activation of Nuclear Respiratory Factor 1
Piantadosi, C. A., & Suliman, H. B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508805200 · Cited by 259
Self-citation
Mitochondrial H2O2 Regulates the Angiogenic Phenotype via PTEN Oxidation
Connor, K. M., Subbaram, S., Regan, K. J., Nelson, K. K., Mazurkiewicz, J. E., Bartholomew, P. J., Aplin, A. E., Tai, Y.-T., Aguirre-Ghiso, J., Flores, S. C., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410690200 · Cited by 251
Mitochondrial Respiratory Chain and NAD(P)H Oxidase Are Targets for theAntiproliferative Effect of Carbon Monoxide in Human Airway SmoothMuscle
Taillé, C., El-Benna, J., Lanone, S., Boczkowski, J., & Motterlini, R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503512200 · Cited by 246
Vascular Smooth Muscle Cell Heme Oxygenases Generate Guanylyl Cyclase–Stimulatory Carbon Monoxide
Christodoulides, N., Durante, W., Kroll, M. H., & Schafer, A. I. (1995) · Circulation · doi:10.1161/01.cir.91.9.2306 · Cited by 244
Apoptosis and Delayed Neuronal Damage after Carbon Monoxide Poisoning in the Rat
Piantadosi, C. A., Zhang, J., Levin, E. D., Folz, R. J., & Schmechel, D. E. (1997) · Experimental Neurology · doi:10.1006/exnr.1997.6584 · Cited by 243
Self-citation
Hypoxia-inducible factor 1α stabilization by carbon monoxide results in cytoprotective preconditioning
Chin, B. Y., Jiang, G., Wegiel, B., Wang, H. J., MacDonald, T. Y., Zhang, X., Gallo, D. J., Cszimadia, E., Bach, F. H., Lee, P. J., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609611104 · Cited by 228
Carbon Monoxide Protects against Liver Failure through Nitric Oxide–induced Heme Oxygenase 1
Zuckerbraun, B. S., Billiar, T. R., Otterbein, S. L., Kim, P. K. M., Liu, F., Choi, A. M. K., Bach, F. H., & Otterbein, L. E. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20031003 · Cited by 220
Carbon Monoxide and Nitric Oxide Suppress the Hypoxic Induction of Vascular Endothelial Growth Factor Gene via the 5′ Enhancer
Liu, Y., Christou, H. A., Morita, T., Laughner, E., Semenza, G. L., & Kourembanas, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.24.15257 · Cited by 218
Heme Is a Carbon Monoxide Receptor for Large-Conductance Ca 2+ -Activated K + Channels
Jaggar, J. H., Li, A., Parfenova, H., Liu, J., Umstot, E. S., Dopico, A. M., & Leffler, C. W. (2005) · Circulation Research · doi:10.1161/01.res.0000186180.47148.7b · Cited by 218
Biological Chemistry of Carbon Monoxide
Piantadosi, C. A. (2002) · Antioxidants and Redox Signaling · doi:10.1089/152308602753666316 · Cited by 201
Self-citation
Heme oxygenase‐1‐derived carbon monoxide protects hearts from transplant‐associated ischemia reperfusion injury
Akamatsu, Y., Haga, M., Tyagi, S., Yamashita, K., Graça-Souza, A. V., Öllinger, R., Czismadia, E., May, G. A., Ifedigbo, E., Otterbein, L. E., et al. (2004) · The FASEB Journal · doi:10.1096/fj.03-0921fje · Cited by 201
Heme oxygenase activity as measured by carbon monoxide production
Vreman, H. J., & Stevenson, D. K. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90006-1 · Cited by 200
Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury
Zhang, X., Shan, P., Alam, J., Fu, X.-Y., & Lee, P. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m408092200 · Cited by 198
Antiapoptotic role of heme oxygenase (HO) and the potential of HO as a target in anticancer treatment
Fang, J. Q., Akaike, T., & Maeda, H. (2004) · APOPTOSIS · doi:10.1023/b:appt.0000012119.83734.4e · Cited by 192
Adaptive responses and apoptosis in endothelial cells exposed to carbon monoxide
Thom, S. R., Fisher, D., Xu, Y., Notarfrancesco, K., & Ischiropoulos, H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.3.1305 · Cited by 192
CO–metal interaction: vital signaling from a lethal gas
Boczkowski, J., Poderoso, J. J., & Motterlini, R. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.09.001 · Cited by 185
The structure of carbonmonoxy neuroglobin reveals a heme-sliding mechanism for control of ligand affinity
Vallone, B., Nienhaus, K., Matthes, A., Brunori, M., & Nienhaus, G. U. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407633101 · Cited by 184
THE LIGHT REVERSIBLE CARBON MONOXIDE INHIBITION OF THE STEROID C21-HYDROXYLASE SYSTEM OF THE ADRENAL CORTEX.
Estabrook, R. W., Cooper, D. Y., & Rosenthal, O. (1963) · PubMed · Cited by 183
Carbon monoxide inhibits apoptosis in vascular smooth muscle cells
Liu, X. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00410-8 · Cited by 182
Activation of soluble guanylate cyclase by carbon monoxide and inhibition by superoxide anion
Brüne, B., SCHMIDT, K., & Ullrich, V. (1990) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1990.tb19276.x · Cited by 182
Allosteric Regulation and Temperature Dependence of Oxygen Binding in Human Neuroglobin and Cytoglobin
Fago, A., Hundahl, C. A., Dewilde, S., Gilany, K., Moens, L. J., & Weber, R. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407126200 · Cited by 181
Activation of Matrix Metalloproteinase-2 by Overexpression of Manganese Superoxide Dismutase in Human Breast Cancer MCF-7 Cells Involves Reactive Oxygen Species
Zhang, H. J., Zhao, W., Venkataraman, S., Robbins, M. E. C., Buettner, G. R., Kregel, K. C., & Oberley, L. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109801200 · Cited by 179
Mitochondrial Biogenesis Restores Oxidative Metabolism during Staphylococcus aureus Sepsis
Haden, D. W., Suliman, H. B., Carraway, M. S., Welty‐Wolf, K. E., Ali, A. S., Shitara, H., Yonekawa, H., & Piantadosi, C. A. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200701-161oc · Cited by 179
Self-citation
Function of cytochrome P-450 of microsomes.
Omura, T., Sato, R., COOPER, D. Y., Rosenthal, O., & Estabrook, R. W. (1965) · PubMed · Cited by 175
Vascular Endothelial Cells Generate Peroxynitrite in Response to Carbon Monoxide Exposure
Thom, S. R., Xu, Y., & Ischiropoulos, H. (1997) · Chemical Research in Toxicology · doi:10.1021/tx970041h · Cited by 173
Acquired resistance to acute oxidative stress. Possible role of heme oxygenase and ferritin.
Vogt, B. A., Alam, J., Croatt, A. J., Vercellotti, G. M., & Nath, K. A. (1995) · PubMed · Cited by 168
A re‐evaluation of the spectral, potentiometric and energy‐linked properties of cytochrome c oxidase in mitochondria
Wikström, M. K. F., Harmon, H. J., Ingledew, W. J., & Chance, B. (1976) · FEBS Letters · doi:10.1016/0014-5793(76)80127-5 · Cited by 164
Mechanisms of carbon monoxide toxicity
Coburn, R. F. (1979) · Preventive Medicine · doi:10.1016/0091-7435(79)90008-2 · Cited by 156
Heme oxygenase-1–derived carbon monoxide is an autocrine inhibitor of vascular smooth muscle cell growth
Peyton, K. J., Reyna, S. V., Chapman, G. B., Ensenat, D., Liu, X., Wang, H., Schafer, A. I., & Durante, W. (2002) · Blood · doi:10.1182/blood.v99.12.4443 · Cited by 156
Carbon Monoxide Protects Against Cardiac Ischemia—Reperfusion Injury In Vivo via MAPK and Akt—eNOS Pathways
Fujimoto, H., Ohno, M., Ayabe, S., Kobayashi, H., Ishizaka, N., Kimura, H., Yoshida, K.-I., & Nagai, R. (2004) · Arteriosclerosis, Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000142364.85911.0e · Cited by 153
Heme Inhibits Human Neutrophil Apoptosis: Involvement of Phosphoinositide 3-Kinase, MAPK, and NF-κB
Arruda, M. A., Rossi, A. G., de Freitas, M. S., Barja‐Fidalgo, C., & Graça-Souza, A. V. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.2023 · Cited by 147
Carbon Monoxide: Innovative Anti-inflammatory Properties of an Age-Old Gas Molecule
Otterbein, L. E. (2002) · Antioxidants and Redox Signaling · doi:10.1089/152308602753666361 · Cited by 147
In vivo binding of carbon monoxide to cytochrome c oxidase in rat brain
Brown, S. D., & Piantadosi, C. A. (1990) · Journal of Applied Physiology · doi:10.1152/jappl.1990.68.2.604 · Cited by 146
Self-citation
The Heme Oxygenase System: Update 2005
Maines, M. D. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1761 · Cited by 146
A kinetic description of ligand binding to sperm whale myoglobin.
Gibson, Q. H., Olson, J. S., McKinnie, R. E., & Rohlfs, R. J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67514-3 · Cited by 144
Carbon monoxide attenuates aeroallergen-induced inflammation in mice
Chapman, J. T., Otterbein, L. E., Elias, J. A., & Choi, A. M. K. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.281.1.l209 · Cited by 144
Adenovirus-Mediated Heme Oxygenase-1 Gene Expression Stimulates Apoptosis in Vascular Smooth Muscle Cells
Liu, X., Chapman, G. B., Wang, H., & Durante, W. (2002) · Circulation · doi:10.1161/hc0102.101369 · Cited by 142
Endoplasmic Reticulum Stress Stimulates Heme Oxygenase-1 Gene Expression in Vascular Smooth Muscle
Liu, X., Peyton, K. J., Ensenat, D., Wang, H., Schafer, A. I., Alam, J., & Durante, W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410413200 · Cited by 140
Modulation of cyclic guanosine monophosphate levels in cultured aortic smooth muscle cells by carbon monoxide
Ramos, K. S., Lin, H., & McGrath, J. J. (1989) · Biochemical Pharmacology · doi:10.1016/0006-2952(89)90347-x · Cited by 138
Heme oxygenase 1 expression induced by IL-10 requires STAT-3 and phosphoinositol-3 kinase and is inhibited by lipopolysaccharide
Ricchetti, G., Williams, L. M., & Foxwell, B. M. J. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0104046 · Cited by 138
Inhibition of cellular respiration by endogenously produced carbon monoxide
D’Amico, G., Lam, F., Hagen, T., & Moncada, S. (2006) · Journal of Cell Science · doi:10.1242/jcs.02914 · Cited by 131
Carbon Monoxide Signaling in Promoting Angiogenesis in Human Microvessel Endothelial Cells
Volti, G. L., Sacerdoti, D., Sangras, B., Vanella, A., Mezentsev, A., Scapagnini, G., Falck, J. R., & Abraham, N. G. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.704 · Cited by 124
The Heme Environment of Mouse Neuroglobin
Couture, M., Burmester, T., Hankeln, T., & Rousseau, D. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103907200 · Cited by 123
Redox Regulation in Neurodegeneration and Longevity: Role of the Heme Oxygenase and HSP70 Systems in Brain Stress Tolerance
Calabrese, V., Stella, A. M. G., Butterfield, D. A., & Scapagnini, G. (2004) · Antioxidants and Redox Signaling · doi:10.1089/ars.2004.6.895 · Cited by 117
Mitochondrial Function Is Required for Hydrogen Peroxide-induced Growth Factor Receptor Transactivation and Downstream Signaling
Chen, K., Thomas, S. R., Albano, A., Murphy, M. P., & Keaney, J. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404859200 · Cited by 117
Caveolin-1 expression by means of p38β mitogen-activated protein kinase mediates the antiproliferative effect of carbon monoxide
Kim, H. P., Wang, X. B., Nakao, A., Kim, S. I., Murase, N., Choi, M. E., Ryter, S. W., & Choi, A. M. K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501345102 · Cited by 114
Carbon Monoxide Suppresses Bleomycin-Induced Lung Fibrosis
Zhou, Z., Song, R., Fattman, C. L., Greenhill, S. R., Alber, S. M., Oury, T. D., Choi, A. M. K., & Morse, D. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62229-8 · Cited by 110
Carbon Monoxide Produced by Heme Oxygenase-1 in Response to Nitrosative Stress Induces Expression of Glutamate-Cysteine Ligase in PC12 Cells via Activation of Phosphatidylinositol 3-Kinase and Nrf2 Signaling
Li, M., Jang, J.-H., Na, H., Cha, Y., & Surh, Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701916200 · Cited by 109
CO-Sensing Mechanisms
Roberts, G. P., Youn, H., & Kerby, R. L. (2004) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.68.3.453-473.2004 · Cited by 108
Simultaneous production of carbon monoxide and thiobarbituric acid reactive substances in rat tissue preparations by an iron-ascorbate system
Vreman, H. J., Wong, R. J., Sanesi, C. A., Dennery, P. A., & Stevenson, D. K. (1998) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-76-12-1057 · Cited by 103
Stopped-Flow Analysis of CO and NO Binding to Inducible Nitric Oxide Synthase
Abu‐Soud, H. M., Wu, C., Ghosh, D. K., & Stuehr, D. J. (1998) · Biochemistry · doi:10.1021/bi972398q · Cited by 103
L-arginine and calmodulin regulation of the heme iron reactivity in neuronal nitric oxide synthase.
Matsuoka, A., Stuehr, D. J., Olson, J. S., Clark, P., & Ikeda‐Saito, M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31996-8 · Cited by 99
CooA, a paradigm for gas sensing regulatory proteins
ROBERTS, G., Kerby, R. L., Youn, H., & CONRAD, M. (2004) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2004.10.032 · Cited by 99
CARBON MONOXIDE BONDING IN HEMEPROTEINS *
Caughey, W. S. (1970) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1970.tb49781.x · Cited by 99
Measurement of Endogenous Carbon Monoxide Formation in Biological Systems
Marks, G. S., Vreman, H. J., McLaughlin, B. E., Brien, J. F., & Nakatsu, K. (2002) · Antioxidants and Redox Signaling · doi:10.1089/152308602753666325 · Cited by 98
Ligand Selectivity of Soluble Guanylyl Cyclase
Martin, E., Berka, V., Bogatenkova, E., Murad, F., & Tsai, A.-L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601078200 · Cited by 97
The formation of carbon monoxide during peroxidation of microsomal lipids
Wolff, D. G., & Bidlack, W. R. (1976) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(76)90199-6 · Cited by 96
Purification and partial characterization of the b-type cytochrome from human polymorphonuclear leukocytes.
Lutter, R., van Schaik, M. L., van Zwieten, R., Wever, R., Roos, D., & Hamers, M. N. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89544-8 · Cited by 94
Carbon monoxide mediates heme oxygenase 1 induction via Nrf2 activation in hepatoma cells
Lee, B.-S., Heo, J., Kim, Y., Shim, S. M., Pae, H., Kim, Y., & Chung, H. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.03.058 · Cited by 89
Myoglobin O2 tension determined from measurement of carboxymyoglobin in skeletal muscle
Coburn, R. F., & Mayers, L. (1971) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1971.220.1.66 · Cited by 86
Recent advances in heme-protein sensors
Chan, M. K. (2001) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(00)00193-9 · Cited by 81
Carbon monoxide, oxidative stress, and mitochondrial permeability pore transition
Piantadosi, C. A., Carraway, M. S., & Suliman, H. B. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.11.020 · Cited by 80
Self-citation
Simultaneous production of carbon monoxide and thiobarbituric acid reactive substances in rat tissue preparations by an iron-ascorbate system
Vreman, H. J., Wong, R. J., Sanesi, C. A., et al. (1998) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y98-126 · Cited by 79
Redox-dependent Matrix Metalloproteinase-1 Expression Is Regulated by JNK through Ets and AP-1 Promoter Motifs
Nelson, K. K., Subbaram, S., Connor, K. M., Dasgupta, J., Ha, X.-F., Meng, T., Tonks, N. K., & Melendez, J. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601820200 · Cited by 78
Protein thiol modification and apoptotic cell death as cGMP-independent nitric oxide (NO) signaling pathways
Brüne, B., Mohr, S., & Meßmer, U. K. (1995) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/bfb0048263 · Cited by 76
Resonance Raman Studies of Cytochrome c‘ Support the Binding of NO and CO to Opposite Sides of the Heme: Implications for Ligand Discrimination in Heme-Based Sensors
Andrew, C. R., Green, E. L., Lawson, D. M., & Eady, R. R. (2001) · Biochemistry · doi:10.1021/bi0023652 · Cited by 75
Carbon Monoxide Promotes Fas/CD95-induced Apoptosis in Jurkat Cells
Song, R., Zhou, Z., Kim, P. K. M., Shapiro, R. A., Liu, F., Ferran, C. J., Choi, A. M. K., & Otterbein, L. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406105200 · Cited by 72
NO Synthase Isozymes Have Distinct Substrate Binding Sites
Fan, B., Wang, J., Stuehr, D. J., & Rousseau, D. L. (1997) · Biochemistry · doi:10.1021/bi9715369 · Cited by 72
Nitric oxide priming protects nitric oxide-mediated apoptosis via HEME OXYGENASE-1 induction
Choi, B., Pae, H., & Chung, H. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00064-9 · Cited by 71
CARBON MONOXIDE ACTUATES O2-LIMITED HEME DEGRADATION IN THE RAT BRAIN
Cronje, F. J., Carraway, M. S., Freiberger, J. J., Suliman, H. B., & Piantadosi, C. A. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.08.022 · Cited by 71
Self-citation
Role of NF-kB and p38 MAP Kinase Signaling Pathways in the Lipopolysaccharide-Dependent Activation of Heme Oxygenase-1 Gene Expression
Wijayanti, N., Huber, S., Samoylenko, A., Kietzmann, T., & Immenschuh, S. (2004) · Antioxidants and Redox Signaling · doi:10.1089/ars.2004.6.802 · Cited by 71
Role of endothelial carbon monoxide in attenuated vasoreactivity following chronic hypoxia
Caudill, T. K., Resta, T. C., Kanagy, N. L., & Walker, B. R. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.4.r1025 · Cited by 69
Production of Hydroxyl Radical in the Hippocampus After CO Hypoxia or Hypoxic Hypoxia in the Rat
Piantadosi, C. A., Zhang, J., & It, D. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00423-6 · Cited by 68
Self-citation
Structural Characterization of the Proximal and Distal Histidine Environment of Cytoglobin and Neuroglobin
Sawai, H., Makino, M., Mizutani, Y., Ohta, T., Sugimoto, H., Uno, T., Kawada, N., Yoshizato, K., Kitagawa, T., & Shiro, Y. (2005) · Biochemistry · doi:10.1021/bi050997o · Cited by 68
REACTIONS OF OXYGEN WITH HEMOGLOBIN, CYTOCHROME C OXIDASE AND OTHER HEMEPROTEINS*
Caughey, W. S., Barlow, C., Maxwell, J. C., Volpe, J. A., & Wallace, W. J. (1975) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1975.tb41517.x · Cited by 62
Regulation of rat heme oxygenase-1 expression by interleukin-6 via the Jak/STAT pathway in hepatocytes
Tron, K., Samoylenko, A., Musikowski, G., Kobe, F., Immenschuh, S., Schaper, F., Ramadori, G. P., & Kietzmann, T. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2005.12.019 · Cited by 51
Concentration of Carbon Monoxide (CO) in Postmortem Human Tissues: Effect of Environmental CO Exposure*
Vreman, H. J., Wong, R. J., Stevenson, D. K., Smialek, J. E., Fowler, D. R., Li, L., Vigorito, R. D., & Zielke, H. R. (2006) · Journal of Forensic Sciences · doi:10.1111/j.1556-4029.2006.00212.x · Cited by 47
Peroxynitrite-mediated inactivation of heme oxygenases
Kinobe, R. T., Ji, Y., & Nakatsu, K. (2004) · BMC Pharmacology · doi:10.1186/1471-2210-4-26 · Cited by 46
Oxygenation of carbon monoxide by bovine heart cytochrome c oxidase
Young, L. J., & Caughey, W. S. (1986) · Biochemistry · doi:10.1021/bi00349a022 · Cited by 41
Human Biliverdin Reductase, a Previously Unknown Activator of Protein Kinase C βII
Maines, M. D., Miralem, T., Lerner‐Marmarosh, N., Shen, J. Y., & Gibbs, P. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m513427200 · Cited by 41
Pulmonary Vascular Stress from Carbon Monoxide
Thom, S. R., Ohnishi, S. T., Fisher, D., Xu, Y., & Ischiropoulos, H. (1999) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1998.8553 · Cited by 40
Carbon monoxide promotes hypoxic pulmonary vascular remodeling
Carraway, M. S., Ghio, A. J., Suliman, H. B., Carter, J. D., Whorton, A. R., & Piantadosi, C. A. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00211.2001 · Cited by 40
Self-citation
Kinetics of CO binding to the haem domain of murine inducible nitric oxide synthase: differential effects of haem domain ligands
STEVENSON, T. H., Gutiérrez, A., ALDERTON, W. K., Lian, L., & Scrutton, N. S. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3580201 · Cited by 40
Mechanism of oxidative stress from low levels of carbon monoxide.
Thom, & Ischiropoulos, H. (1997) · PubMed · Cited by 38
Carbon monoxide-cytochrome interactions in the brain of the fluorocarbon-perfused rat
Piantadosi, C. A., Sylvia, A. L., Saltzman, H. A., & Jöbsis-VanderVliet, F. F. (1985) · Journal of Applied Physiology · doi:10.1152/jappl.1985.58.2.665 · Cited by 38
Self-citation
Halogenated methanes: metabolism and toxicity.
Ahmed, A. A. E., Kubic, V. L., Stevens, J. L., & Anders, M. W. (1980) · PubMed · Cited by 35
Evidence for a Cyclic Guanosine Monophosphate—Dependent, Carbon Monoxide—Mediated, Signaling System in the Regulation of TNF-α Production by Human Pulmonary Macrophages
Arias‐Díaz, J. (1995) · Archives of Surgery · doi:10.1001/archsurg.1995.01430120041006 · Cited by 32
Differences in brain cytochrome responses to carbon monoxide and cyanide in vivo
Piantadosi, C. A., Sylvia, A. L., & Jöbsis-VanderVliet, F. F. (1987) · Journal of Applied Physiology · doi:10.1152/jappl.1987.62.3.1277 · Cited by 29
Self-citation
EARLY STUDIES OF CO PRODUCTION
Sjöstrand, T. (1970) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1970.tb49767.x · Cited by 25
Light Pulse‐Induced Heme and Iron‐Associated Transcripts in Mouse Brain: A Microarray Analysis
Ben‐Shlomo, R., Akhtar, R. A., Collins, B. H., Judah, D. J., Davies, R., & Kyriacou, C. P. (2005) · Chronobiology International · doi:10.1081/cbi-200062353 · Cited by 25
THE BURNING OF CO IN TISSUES
Fenn, W. O. (1970) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1970.tb49772.x · Cited by 24
Correlation of carbon monoxide and bilirubin production by tissue homogenates
Vreman, H. J., Stevenson, D. K., Henton, D. H., & Rosenthal, P. J. (1988) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(88)80134-8 · Cited by 23
CO binding studies of nitric oxide synthase: effects of the substrate, inhibitors and tetrahydrobiopterin
Sato, H., Nomura, S., Sagami, I., Ito, O., Daff, S. N., & Shimizu, T. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00699-1 · Cited by 21
Carbon Monoxide Reversibly Alters Iron Homeostasis and Respiratory Epithelial Cell Function
Ghio, A. J., Stonehuerner, J. G., Dailey, L. A., Richards, J. H., Madden, M. D., Deng, Z., Nguyen, N.-B., Callaghan, K. D., Yang, F., & Piantadosi, C. A. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0179oc · Cited by 19
Self-citation
NADPH-cytochrome c reductase from human neutrophil membranes: purification, characterization and localization
Nisimoto, Y., Otsuka-Murakami, H., & Iwata, S. (1994) · Biochemical Journal · doi:10.1042/bj2970585 · Cited by 16
Role of the Interdomain Linker Probed by Kinetics of CO Ligation to an Endothelial Nitric Oxide Synthase Mutant Lacking the Calmodulin Binding Peptide (Residues 503−517 in Bovine)
Żemojtel, T., Scheele, J. S., Pavel Martasek, E., Masters, B. S. S., Sharma, V. S., & Magde, D. (2003) · Biochemistry · doi:10.1021/bi026886w · Cited by 15
Rat carotid body chemosensory discharge and glomus cell HIF-1α expression in vitro: regulation by a common oxygen sensor
Roy, A., Baby, S. M., Wilson, D. F., & Lahiri, S. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00882.2006 · Cited by 9
Analysis of the kinetics of CO binding to neuronal nitric oxide synthase by flash photolysis: dual effects of substrates, inhibitors, and tetrahydrobiopterin
Bengea, S., Araki, Y., Ito, O., Igarashi, J., Sagami, I., & Shimizu, T. (2004) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2004.04.009 · Cited by 7
Reactivity of photoreduced cytochrome aa3 complexes with molecular oxygen
Nicholls, P. J., & Chanady, G. A. (1981) · Biochemical Journal · doi:10.1042/bj1940713 · Cited by 6
Kinetics of ligand binding of cytochrome oxidases: a comparative study
Basu, A., Yin, M. R., Waterland, R. A., & Chance, B. (1994) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(94)90235-6 · Cited by 4

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Authors: Piantadosi, C. A.
Affiliations: Duke University (US)
Corresponding author: Piantadosi, Claude A.
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 2008-09
Volume: 45
Issue: 5
Pages: 562-569
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/j.freeradbiomed.2008.05.013
PMC: PMC2570053
OpenAlex: W2087826558
Cited by: 281
References: 145
Citations by year: 2026: 11 · 2025: 10 · 2024: 15 · 2023: 13 · 2022: 19 · 2021: 16 · 2020: 21 · 2019: 8 · 2018: 16 · 2017: 13 · 2016: 7 · 2015: 11 · 2014: 17 · 2013: 16 · 2012: 16
FWCI: 1.83
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL090679)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: carbon monoxide, reactive oxygen species, oxidative stress, heme proteins, heme oxygenase, pro-oxidant activity, redox signaling, stress-activated kinases, redox-sensitive transcription factors, antioxidant enzymes, co-toxicity
MeSH terms: Adaptation, Biological, Animals, Carbon Monoxide, Hemeproteins, Humans, Signal Transduction, Reactive Oxygen Species, Oxidative Stress

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Carbon monoxide, reactive oxygen signaling, and oxidative stress

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