Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio

Emerling, Brooke M.; Weinberg, Frank; Snyder, Colleen; Burgess, Zach; Mutlu, Gökhan M.; Viollet, Benoit; Budinger, G.R. Scott; Chandel, Navdeep S.

doi:10.1016/j.freeradbiomed.2009.02.019

Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio

AMP-activated protein kinase (AMPK) is a sensor of cellular energy status found in metazoans that is known to be activated by stimuli that increase the cellular AMP/ATP ratio. Full activation of AMPK requires specific phosphorylation within the activation loop of the catalytic domain of the α-sub…