What really happens in the neutrophil phagosome?
Open accessAbstract
Current viewpoints concerning the bactericidal mechanisms of neutrophils are reviewed from a perspective that emphasizes challenges presented by the inability to duplicate ex vivo the intracellular milieu. Among the challenges considered are the influences of confinement upon substrate availability and reaction dynamics, direct and indirect synergistic interactions between individual toxins, and bacterial responses to stressors. Approaches to gauging relative contributions of various oxidative and nonoxidative toxins within neutrophils using bacteria and bacterial mimics as intrinsic probes are also discussed.
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The most common sources of MPO are neutrophils, where the enzyme is located at the lysosomal level.
“The most common sources are neutrophils, where the enzyme is located at the lysosomal level [29].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [29]
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References 168 · Cited by 124
Research works printed but not linked: 2
- [20]See e.g. Voet D Voet JG Biochemistry 1995 Wiley New York 2nd ed.
- [155]Elsbach P Weiss J Gallin JI Goldstein IM Snyderman R Phagocytic cells: oxygen-independent antimicrobial systems of phagocytes. Inflammation: basic principles and clinical correlates 1988 445 470 Raven Press New York
- Authors
- Hurst, J. K.
- Affiliations
- Washington State University (US)
- Corresponding author
- Hurst, James K.
- ORCID
- Hurst, James K.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 53
- Issue
- 3
- Pages
- 508-520
- ISSN
- 0891-5849 (ISSN-L)
- PMC
- PMC4382085
- OpenAlex
- W2070505577
- Cited by
- 124
- References
- 168
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 4 · 2023: 15 · 2022: 10 · 2021: 11 · 2020: 6 · 2019: 15 · 2018: 8 · 2017: 6 · 2016: 11 · 2015: 8 · 2014: 10 · 2013: 8 · 2012: 4
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R01AI015834, AI-15842)
- Department of Biochemistry and Biophysics, College of Science, Oregon State University
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Keywords
- bactericidal mechanism, respiratory burst, phagocytosis, bacterial stress response, toxin synergy, intracellular bacterial killing
- MeSH terms
- Animals, Escherichia coli, Humans, Immunity, Innate, Neutrophils, Oxidation-Reduction, Phagosomes, Staphylococcus aureus, Reactive Oxygen Species, Host-Pathogen Interactions
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