An overview of the chemistry and biology of reactive aldehydes
Open accessAbstract
The nonenzymatic free radical generation of reactive aldehydes is known to contribute to diseases of sustained oxidative stress including rheumatoid arthritis, atherosclerosis, neurodegeneration, and a number of liver diseases. At the same time, the accumulation of lipid electrophiles has been demonstrated to play a role in cell signaling events through modification of proteins critical for cellular homeostasis. Given the broad scope of reactivity profiles and the ability to modify numerous proteomic and genomic processes, new emphasis is being placed on a systems-based analysis of the consequences of electrophilic adduction. This review focuses on the generation and chemical reactivity of lipid-derived aldehydes with a special focus on the homeostatic responses to electrophilic stress.
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In hepatic Kupffer cells, 4-HNE adducts are present and activate infiltration of neutrophils into the liver, leading to activation of HSCs and an inflammatory cytokine response; these findings indicate a contributing role of MAA and 4-HNE adducts in promoting the hepatic immune response associated with ALD development.
“In hepatic Kupffer cells, 4-HNE adducts are also present and activate the infiltration of neutrophils into the liver, leading to the activation of HSCs and an inflammatory cytokine response226–228.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [226]
Highly-reactive lipid peroxides including 4-HNE and 4-ONE, despite their extremely short half-lives, can suppress the activities of many mitochondrial proteins likely through adduct formation with a few amino acids such as Cys, His, Arg, and Lys of target proteins.
“Recent results showed that highly-reactive lipid peroxides including 4-HNE and 4-ONE, despite their extremely short half-lives, can suppress the activities of many mitochondrial proteins likely through adduct formation with a few amino acids such as Cys, His, Arg, and Lys of target proteins [168].”
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References 57 · Cited by 237
Research works printed but not linked: 1
- [8]McNaught AD Wilkinson A International Union of Pure and Applied Chemistry Compendium of chemical terminology: IUPAC recommendations Oxford [England]; Malden, MA, USA Blackwell Science 1997
- Authors
- Fritz, K. S., & Petersen, D. R.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Petersen, Dennis R.
- ORCID
- Fritz, Kristofer S.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 59
- Pages
- 85-91
- ISSN
- 0891-5849 (ISSN-L)
- PMC
- PMC3540155
- OpenAlex
- W2031453558
- Cited by
- 237
- References
- 57
- Citations by year
- 2026: 14 · 2025: 16 · 2024: 19 · 2023: 24 · 2022: 20 · 2021: 22 · 2020: 14 · 2019: 22 · 2018: 12 · 2017: 15 · 2016: 11 · 2015: 25 · 2014: 9 · 2013: 11
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH/NIDDK (5R01DK074487-05)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Keywords
- reactive aldehydes, oxidative stress, protein modification, rheumatoid arthritis, atherosclerosis, neurodegeneration, liver disease, signal transduction
- MeSH terms
- Aldehydes, Animals, Free Radicals, Humans, Lipids, Lipid Peroxidation
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