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Revisiting an age-old question regarding oxidative stress
Open accessAbstract
Significant advances in maintaining health throughout life can be made through a clear understanding of the fundamental mechanisms that regulate aging. The Oxidative Stress Theory of Aging (OSTA) is probably the most well studied mechanistic theory of aging and suggests that the rate of aging is controlled by accumulation of oxidative damage. To directly test the OSTA, aging has been measured in several lines of mice with genetic alterations in the expression of enzymatic antioxidants. Under its strictest interpretation, these studies do not support the OSTA, as modulation of antioxidant expression does not generally affect mouse life span. However, the incidence of many age-related diseases and pathologies is altered in these models, suggesting that oxidative stress does significantly influence some aspects of the aging process. Further, oxidative stress may affect aging in disparate patterns among tissues or under various environmental conditions. In this review, we summarize the current literature regarding aging in antioxidant mutant mice and offer several interpretations of their support of the OSTA.
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Oxidative stress may have an impact on the aging process by causing biochemical and physiological changes that accelerate age-related diseases.
“Lastly, oxidative stress may also have an impact on the aging process by causing biochemical and physiological changes that accelerate age-related diseases [140].”
From Ultraviolet Radiation‐Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging (2016) · cites this paper as [140]
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References 129 · Cited by 64
Metadata
- Authors
- Edrey, Y. H., & Salmon, A. B.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Salmon, Adam B.
- ORCID
- Salmon, Adam B.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 71
- Pages
- 368-378
- ISSN
- 0891-5849 (ISSN-L)
- PMC
- PMC4049226
- OpenAlex
- W2056205714
- Cited by
- 64
- References
- 129
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 7 · 2020: 5 · 2019: 7 · 2018: 5 · 2017: 6 · 2016: 8 · 2015: 11 · 2014: 3
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Geriatric Research, Education and Clinical Center of the South Texas Veterans Health Care Systems (5P30 AG013319-19)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- oxidative stress, aging, antioxidant enzymes, lifespan, age-related diseases, tissue-specific aging
- MeSH terms
- Aging, Animals, Catalase, Glutathione Peroxidase, Longevity, Mutation, Oxidation-Reduction, Superoxide Dismutase, Thioredoxins, Gene Expression, Oxidative Stress, Methionine Sulfoxide Reductases, Mice, Peroxiredoxins
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