Glutathione sulfinamide serves as a selective, endogenous biomarker for nitroxyl after exposure to therapeutic levels of donors

Johnson, Gail M.; Chozinski, Tyler J.; Gallagher, Elyssia S.; Aspinwall, Craig A.; Miranda, Katrina M.

doi:10.1016/j.freeradbiomed.2014.07.022

Glutathione sulfinamide serves as a selective, endogenous biomarker for nitroxyl after exposure to therapeutic levels of donors

Nitroxyl (HNO) donors exhibit promising pharmacological characteristics for treatment of cardiovascular disorders, cancer and alcoholism. However, whether HNO also serves as an endogenous signaling agent is currently unknown, largely due to the inability to selectively and sensitively detect HNO …