The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
p62 links autophagy and Nrf2 signaling
Open accessAbstract
The Nrf2-Keap1-ARE pathway is a redox and xenobiotic sensitive signaling axis that functions to protect cells against oxidative stress, environmental toxicants, and harmful chemicals through the induction of cytoprotective genes. To enforce strict regulation, cells invest a great deal of energy into the maintenance of the Nrf2 pathway to ensure rapid induction upon cellular insult and rapid return to basal levels once the insult is mitigated. Because of the protective role of Nrf2 transcriptional programs, controlled activation of the pathway has been recognized as a means for chemoprevention. On the other hand, constitutive activation of Nrf2, due to somatic mutations of genes that control Nrf2 degradation, promotes carcinogenesis and imparts chemoresistance to cancer cells. Autophagy, a bulk protein degradation process, is another tightly regulated complex cellular process that functions as a cellular quality control system to remove damaged proteins or organelles. Low cellular nutrient levels can also activate autophagy, which acts to restore metabolic homeostasis through the degradation of macromolecules to provide nutrients. Recently, these two cellular pathways were shown to intersect through the direct interaction between p62 (an autophagy adaptor protein) and Keap1 (the Nrf2 substrate adaptor for the Cul3 E3 ubiquitin ligase). Dysregulation of autophagy was shown to result in prolonged Nrf2 activation in a p62-dependent manner. In this review, we will discuss the progress that has been made in dissecting the intersection of these two pathways and the potential tumor-promoting role of prolonged Nrf2 activation.
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Cites
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“According to the hinge and latch model, the ETGE motif has a higher affinity for Keap1 than the DLG motif, which causes the latter to dynamically associate and dissociate from Keap1 to generate oscillating “closed” (associated) and “open” (dissociated) conformations [29–33].”
Cited by
NRF2 and the Hallmarks of Cancer
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Self-citationNrf2 at the heart of oxidative stress and cardiac protection
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The interplay of ROS and the PI3K/Akt pathway in autophagy regulation
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Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes
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SQSTM1/p62: a potential target for neurodegenerative disease
Ma, S., Attarwala, I. Y., & Xie, X.-Q. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00516 · Cited by 185
Metadata
- Authors
- Jiang, T., Harder, B., Rojo de la Vega, M., Wong, P. K., Chapman, E., & Zhang, D. D.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 88
- Issue
- Pt B
- Pages
- 199-204
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W775311174
- Cited by
- 639
- References
- 20
- FWCI
- 12.87
- Type
- journal article
- Language
- en
- Open access
- green
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