Nrf2 in keratinocytes modulates UVB-induced DNA damage and apoptosis in melanocytes through MAPK signaling

Jeayeng, Saowanee; Wongkajornsilp, Adisak; Slominski, Andrzej T.; Jirawatnotai, Siwanon; Sampattavanich, Somponnat; Panich, Uraiwan

doi:10.1016/j.freeradbiomed.2017.05.009

Nrf2 in keratinocytes modulates UVB-induced DNA damage and apoptosis in melanocytes through MAPK signaling

Responses of melanocytes (MC) to ultraviolet (UV) irradiation can be influenced by their neighbouring keratinocytes (KC). We investigated the role of Nrf2 in regulating paracrine effects of KC on UVB‐induced MC responses through phosphorylation of MAPKs in association with oxidative stress in pri…