The ins and outs of iron: Escorting iron through the mammalian cytosol
Abstract
Mammalian cells contain thousands of metalloproteins and have evolved sophisticated systems for ensuring that metal cofactors are correctly assembled and delivered to their proper destinations. Equally critical in this process are the strategies to avoid the insertion of the wrong metal cofactor into apo-proteins and to avoid the damage that redox-active metals can catalyze in the cellular milieu. Iron and zinc are the most abundant metal cofactors in cells and iron cofactors include heme, iron-sulfur clusters, and mono- and dinuclear iron centers. Systems for the intracellular trafficking of iron cofactors are being characterized. This review focuses on the trafficking of ferrous iron cofactors in the cytosol of mammalian cells, a process that involves specialized iron-binding proteins, termed iron chaperones, of the poly rC-binding protein family.
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PCBP2 accepts ferrous iron, acts as a chaperone and accompanies iron to the basolateral membrane.
“Therein, PCBP2 (for poly(rC)-binding protein-2) accepts ferrous iron, acts as chaperone and as such accompanies iron to the basolateral membrane (Philpott and Jadhav, 2019;Shi et al., 2008;Yanatori et al., 2017).”
From Iron in infection and immunity (2020) · cites this paper as Philpott and Jadhav, 2019
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References 60 · Cited by 100
- Authors
- Philpott, C. C., & Jadhav, S.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Philpott, Caroline C.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 133
- Pages
- 112-117
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2897032853
- Cited by
- 100
- References
- 60
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 9 · 2023: 19 · 2022: 20 · 2021: 11 · 2020: 16 · 2019: 9
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- iron trafficking, iron chaperone, iron-binding proteins, cytosol, heme, iron-sulfur clusters, zinc, redox-active metals, mammalian cells
- MeSH terms
- Animals, Cytosol, Heme, Humans, Iron, Iron-Sulfur Proteins, Metalloproteins, Sulfur, Molecular Chaperones, Iron-Binding Proteins
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