The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Pyruvate kinase M2: A simple molecule with complex functions
Open accessAbstract
Pyruvate kinase M2 is a critical enzyme that regulates cell metabolism and growth under different physiological conditions. In its metabolic role, pyruvate kinase M2 catalyzes the last glycolytic step which converts phosphoenolpyruvate to pyruvate with the generation of ATP. Beyond this metabolic role in glycolysis, PKM2 regulates gene expression in the nucleus, phosphorylates several essential proteins that regulate major cell signaling pathways, and contribute to the redox homeostasis of cancer cells. The expression of PKM2 has been demonstrated to be significantly elevated in several types of cancer, and the overall inflammatory response. The unusual pattern of PKM2 expression inspired scientists to investigate the unrevealed functions of PKM2 and the therapeutic potential of targeting PKM2 in cancer and other disorders. Therefore, the purpose of this review is to discuss the mechanistic and therapeutic potential of targeting PKM2 with the focus on cancer metabolism, redox homeostasis, inflammation, and metabolic disorders. This review highlights and provides insight into the metabolic and non-metabolic functions of PKM2 and its relevant association with health and disease.
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Tan, J., Zhang, J., Wang, M., Wang, Y., Dong, M., Ma, X., Sun, B., Liu, S., Zhao, Z., Chen, L., et al. (2022) · Molecular Therapy Nucleic Acids · doi:10.1016/j.omtn.2021.12.017 · Cited by 26
Metadata
- Authors
- Alquraishi, M., Puckett, D. L., Alani, D. S., Humidat, A. S., Frankel, V. D., Donohoe, D. R., Whelan, J., & Bettaieb, A.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 143
- Pages
- 176-192
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2967656973
- Cited by
- 173
- References
- 25
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- green
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- Alquraishi, M., Puckett, D. L., Alani, D. S., Humidat, A. S., Frankel, V. D., Donohoe, D. R., Whelan, J., & Bettaieb, A. (2019). Pyruvate kinase M2: A simple molecule with complex functions. Free Radical Biology and Medicine. https://doi.org/10.1016/j.freeradbiomed.2019.08.007
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