CoChat
Sign Up
Cited by 84

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Insulin Resistance Causes Human Gallbladder Dysmotility

Nakeeb, Attila, Comuzzie, Anthony G., Al-Azzawi, Hayder, Sonnenberg, Gabriele E., Kissebah, Ahmed H., Pitt, Henry A.·2006·Journal of Gastrointestinal Surgery
DOI 10.1016/j.gassur.2006.04.005
Open this paper in CoChat — free account

Abstract

Obesity, diabetes, and hyperlipidemia are known risk factors for the development of gallstones. A growing body of animal and human data has correlated insulin resistance with organ dysfunction. The relationship among obesity, diabetes, hyperlipidemia, and abnormal gallbladder motility remains unclear. Therefore, we designed a study to investigate the association among obesity, insulin resistance, hyperlipidemia, and gallbladder dysmotility. One hundred ninety-two healthy adult nondiabetic volunteers were studied. Gallbladder ultrasounds were performed before and after a standardized fatty meal. A gallbladder ejection fraction (EF) was calculated, and an EF of 25% (109 +/- 20 mg/dl versus 78 +/- 2 mg/dl, P 25% (3.3 +/- 1.2 versus 2.0 +/- 0.2, P < 0.05). In obese subjects (n = 66), fasting glucose, insulin, and insulin resistance were not associated with a gallbladder EF < 25%. These data suggest that in lean, nondiabetic volunteers without gallstones, gallbladder dysmotility is associated with an elevated fasting glucose as well as a high index of insulin resistance. We conclude that insulin resistance alone may be responsible for gallbladder dysmotility that may result in acalculous cholecystitis or gallstone formation.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.gassur.2006.04.005

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 1 references

Research works printed but not linked: 41

  1. Carey, 1978, Critical tables for calculating the cholesterol saturation of native bile, J Lipid Res, 19, 945, 10.1016/S0022-2275(20)40677-7 · DOI
  2. Everhart, 1999, Prevalence and ethic differences in gallbladder disease in the United States, Gastorenterology, 117, 632, 10.1016/S0016-5085(99)70456-7 · DOI
  3. Tran, 2003, Diabetes and hyperlipidemia correlate with gallbladder contractility in leptin-related murine obesity, J Gastrointest Surg, 7, 857, 10.1007/s11605-003-0030-z · DOI
  4. Graewin, 2004, Gallbladder myocytes are short and cholecystokinin-resistant in obese diabetic mice, Surgery, 136, 431, 10.1016/j.surg.2004.05.020 · DOI
  5. Graewin, 2004, Nonobese diabetic mice have diminished gallbladder motility and shortened crystal observation time, J Gastrointest Surg, 8, 824, 10.1016/j.gassur.2004.06.014 · DOI
  6. Kissebah, 2000, Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome, Proc Natl Acad Sci U S A, 97, 14478, 10.1073/pnas.97.26.14478 · DOI
  7. Cooperberg, 1980, Real-time ultrasonography: Diagnostic technique of choice in calculous gallbladder disease, N Engl J Med, 302, 1277, 10.1056/NEJM198006053022303 · DOI
  8. Kucio, 1988, Gallbladder motor function in obese versus lean females, Eur J Clin Nutr, 42, 121
  9. Acalovschi, 1992, Ultrasonographic study of gallbladder emptying in obese patients, Int J Obes, 16, 313
  10. Attili, 1997, Factors associated with gallstone disease in the MICOL experience. Multicenter Italian Study on Epidemiology of Cholelithiasis, Hepatology, 26, 809, 10.1002/hep.510260401 · DOI
  11. Heaton, 1991, Symptomatic and silent gallstones in the community, Gut, 32, 10.1136/gut.32.3.316 · DOI
  12. Diehl, 1991, Epidemiology and natural history of gallstone disease, Gastroenterol Clin N Am, 20, 1, 10.1016/S0889-8553(21)00531-8 · DOI
  13. Shaffer, 1977, Biliary lipid secretion in cholesterol gallstone disease: The effect of cholecystectomy and obesity, J Clin Invest, 59, 828, 10.1172/JCI108705 · DOI
  14. Amaral, 1985, Gallbladder disease in the morbidly obese, Am J Surg, 149, 551, 10.1016/S0002-9610(85)80055-6 · DOI · Paper page
  15. Carey, 1978, The physical chemistry of cholesterol solubility in bile. Relationship to gallstone formation and dissolution in man, J Clin Invest, 61, 998, 10.1172/JCI109025 · DOI
  16. Shiffman, 1992, Changes in gallbladder bile composition following gallstone formation and weight reduction, Gastroenterology, 103, 214, 10.1016/0016-5085(92)91115-K · DOI · Paper page
  17. Yu, 1995, Direct G protein activation reverses impaired CCK signaling in human gallbladders with cholesterol stones, Am J Physiol, 269, G659
  18. Behar, 1989, Gallbladder contraction in patients with pigment and cholesterol stones, Gastroenterology, 97, 1470, 10.1016/0016-5085(89)90392-2 · DOI
  19. Vezina, 1990, Increased volume and decreased emptying of the gallbladder in large (morbidly obese, tall normal, and muscular normal) people, Gastroenterology, 98, 1000, 10.1016/0016-5085(90)90025-V · DOI
  20. Barbara, 1987, A population study on the prevalence of gallstone disease: The Sirmione study, Hepatology, 7, 913, 10.1002/hep.1840070520 · DOI
  21. De Santis, 1997, Gallstones and diabetes: A case study in a free-living population sample, Hepatology, 25, 787, 10.1002/hep.510250401 · DOI
  22. Haffner, 1990, Increased prevalence of clinical gallbladder disease in subjects with noninsulin-dependent diabetes mellitus, Am J Epidemiol, 132, 327, 10.1093/oxfordjournals.aje.a115662 · DOI
  23. Stone, 1988, Impairment of gallbladder emptying in diabetes mellitus, Gastroenterology, 95, 170, 10.1016/0016-5085(88)90307-1 · DOI
  24. Chapman, 1998, Gallbladder volume: Comparison of diabetics and controls, Dig Dis Sci, 43, 344, 10.1023/A:1018810523399 · DOI
  25. Guliter, 2003, Evaluation of gallbladder volume and motility in noninsulin-dependent diabetes mellitus patients using real-time ultrasonography, J Clin Gastro, 37, 288, 10.1097/00004836-200310000-00005 · DOI
  26. Scragg, 1984, Plasma lipids and insulin in gallstone disease: A case-control study, Br Med J, 289, 521, 10.1136/bmj.289.6444.521 · DOI
  27. Laasko, 1990, Plasma insulin, serum lipids and lipoproteins in gall stone disease in noninsulin dependent diabetic subjects: A case control study, Gut, 31, 344, 10.1136/gut.31.3.344 · DOI
  28. Ruhl, 2000, Association of diabetes, serum insulin, and C-peptide with gallbladder disease, Hepatology, 31, 299, 10.1002/hep.510310206 · DOI
  29. Gielkens, 1998, Effect of insulin on basal and cholecystokinin-stimulated gallbladder motility in humans, J Hepatol, 28, 595, 10.1016/S0168-8278(98)80282-1 · DOI
  30. Sweeney, 2001, Mechanisms and consequences of Na+,K+ pump regulation by insulin and leptin, Cell Mol Biol, 47, 363
  31. Singh, 2001, Advanced glycation end-products: A review, Diabetologia, 44, 129, 10.1007/s001250051591 · DOI · Paper page
  32. Bucala, 1997, Lipid and lipoprotein modification by AGEs: Role in atherosclerosis, Exp Physiol, 82, 327, 10.1113/expphysiol.1997.sp004028 · DOI
  33. Bravata, 2004, Two measures of insulin sensitivity provided similar information in a U.S. population, J Clin Epidemiol, 57, 1214, 10.1016/j.jclinepi.2004.05.001 · DOI
  34. Tran, 2003, Gallbladder motility in agouti-yellow and leptin-resistant obese mice, J Surg Res, 113, 56, 10.1016/S0022-4804(03)00157-4 · DOI
  35. Goldblatt, 2002, Decreased gallbladder response in leptin-deficient obese mice, J Gastrointest Surg, 6, 438, 10.1016/S1091-255X(01)00046-4 · DOI
  36. Phillips, 2002, Leptin ameliorates the gallbladder's response to neurotransmitters in congenitally obese mice, Gastroenterology, 123, 9
  37. Swartz-Basile, 2004, Alimentary leptin receptors are most abundant in the gallbladder, J Am Coll Surg, 199, 512, 10.1016/j.jamcollsurg.2004.05.010 · DOI
  38. Chen, 1999, Excess membrane cholesterol alters human gallbladder muscle contractility and membrane fluidity, Gastroenterology, 116, 678, 10.1016/S0016-5085(99)70190-3 · DOI
  39. Goldblatt, 2006, Nonalcoholic fatty gallbladder disease: The influence of diet in lean and obese mice, J Gastrointest Surg, 10, 193, 10.1016/j.gassur.2005.07.009 · DOI
  40. Krishnamurthy, 1981, Radionuclide ejection fraction: A technique for quantitative analysis of motor function of the human gallbladder, Gastroenterology, 80, 482, 10.1016/0016-5085(81)90009-3 · DOI
  41. Kao, 1994, Evaluation of gallbladder function by quantitative radionuclide cholescintigraphy in patients with gallbladder sludge or stones, Nucl Med Commun, 15, 742, 10.1097/00006231-199409000-00013 · DOI

Cited by

Sorted by citations

Metadata

Authors
Nakeeb, A., Comuzzie, A. G., Al-Azzawi, H., Sonnenberg, G. E., Kissebah, A. H., & Pitt, H. A.
Venue
Journal of Gastrointestinal Surgery
Publisher
Elsevier BV
Published
2006-07
Volume
10
Issue
7
Pages
940-949
ISSN
1091-255X
DOI
10.1016/j.gassur.2006.04.005
Cited by
84
References
1
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review