A High-Throughput Microphysiological Liver Chip System to Model Drug-Induced Liver Injury Using Human Liver Organoids

Meyer, Sophia R.; Zhang, Charles J.; Garcia, Max A.; Procario, Megan C.; Yoo, Sanghee; Jolly, Amber L.; Kim, Sumin; Kim, Jiho; Baek, Kyusuk; Kersten, Roland D.; Fontana, Robert J.; Sexton, Jonathan Z.

doi:10.1016/j.gastha.2024.08.004

A High-Throughput Microphysiological Liver Chip System to Model Drug-Induced Liver Injury Using Human Liver Organoids

Background and Aims Drug-induced liver injury (DILI) is a major failure mode in pharmaceutical development. This study aims to address the limitations of existing preclinical models by assessing a high-throughput, microfluidic liver-on-a-chip system, termed “Curio Barrier Liver Chips,” and its ca…