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Cited by 102Renal and related cancersDevelopmental Biology and Gene RegulationUrological Disorders and Treatments

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Recent genetic studies of mouse kidney development

Yu, Jing, McMahon, Andrew P, Valerius, M Todd·2004·Current Opinion in Genetics & Development
DOI 10.1016/j.gde.2004.07.009
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Abstract

Recent functional studies in mouse further illustrate the importance of the epithelial-mesenchymal interaction between the ureteric bud epithelium and the metanephric mesenchyme in kidney formation. Genetic ablation of Gdf11, Six1, Slit2/Robo2 reveal a role of these genes in regulating the outgrowth of a single ureteric bud from the Wolffian duct. Studies of Wnt11 and Fras1/Grip1, all expressed in the ureteric bud, show a role for these genes in regulating events in the adjacent metanephric mesenchyme. Furthermore, various approaches were used to address the function of Pod1, Pbx1, the Notch pathway and Brn1 in nephron formation.

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Crossref · 10.1016/j.gde.2004.07.009

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  • The predicted expansion in CCC potential during early postnatal development likely reflects ongoing refinement and stabilisation of predicted intercellular signalling networks following functional maturation, rather than acquisition of additional organ functionality.

    “this predicted expansion in CCC potential likely reflects the ongoing refinement and stabilisation of predicted intercellular signalling networks following functional maturation, rather than a predicted acquisition of additional organ functionality.”

    From Quantitative profiling of lifespan-dependent cell-cell communication potential reveals dynamic ligand-receptor network shifts across mouse tissues (2026) · cites this paper as [39]

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Research works printed but not linked: 38

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Metadata

Authors
Yu, J., McMahon, A. P., & Valerius, M. T.
Affiliations
Harvard University (US)
ORCID
Venue
Current Opinion in Genetics & Development
Publisher
Elsevier BV
Published
2004-10
Volume
14
Issue
5
Pages
550-557
ISSN
0959-437X (ISSN-L)
DOI
10.1016/j.gde.2004.07.009
OpenAlex
W2100847259
Cited by
102
References
0
Citations by year
2026: 1 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 5
FWCI
0.81
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Current Opinion in Genetics & Development (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (F32DK060319)
Topics
  • Health Sciences › Medicine › Oncology › Renal and related cancers
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Health Sciences › Medicine › Urology › Urological Disorders and Treatments
Keywords
kidney development, ureteric bud, metanephric mesenchyme, epithelial-mesenchymal interactions, GDF11, Six1, Wnt11, PBX1, Notch signaling, nephron development, mouse genetics
MeSH terms
Slit Homolog 2 Protein, Animals, Glycoproteins, Kidney, Nerve Tissue Proteins, Homeodomain Proteins, Gene Expression Regulation, Developmental, Bone Morphogenetic Proteins, Intercellular Signaling Peptides and Proteins, Wnt Proteins, Mice, Growth Differentiation Factors

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