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Role of VPS13, a protein with similarity to ATG2, in physiology and disease

Ugur, Berrak, Hancock-Cerutti, William, Leonzino, Marianna, De Camilli, Pietro·2020·Current Opinion in Genetics & Development
DOI 10.1016/j.gde.2020.05.027PMC PMC7746581
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  • The Vps13 complex regulates endosomal recycling towards the Golgi, mitochondria, and autophagosomes by promoting organelle bilayer bridging, and has been implicated in mitochondrial dysfunction in neurodegenerative diseases, including atypical PARK23.

    “The Vps13 complex regulates endosomal recycling towards the Golgi, mitochondria, and autophagosomes by promoting organelle bilayer bridging, and has been implicated in mitochondrial dysfunction in neurodegenerative diseases, including atypical PARK23 [40].”

    From Stabilizing the retromer complex rescues synaptic dysfunction and endosomal trafficking deficits in an Alzheimer’s disease mouse model (2025) · cites this paper as [40]

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Research works printed but not linked: 66

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Metadata

Authors
Ugur, B., Hancock-Cerutti, W., Leonzino, M., & De Camilli, P.
Venue
Current Opinion in Genetics & Development
Publisher
Elsevier BV
Published
2020-12
Volume
65
Pages
61-68
ISSN
0959-437X
DOI
10.1016/j.gde.2020.05.027
PMC
PMC7746581
Cited by
73
References
5
Language
en
Licence
Funders
  • National Institutes of Health
  • Parkinson's Foundation

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