Cited by 282Tendon Structure and TreatmentCellular Mechanics and InteractionsOsteoarthritis Treatment and Mechanisms

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Repetitive mechanical stretching modulates IL-1β induced COX-2, MMP-1 expression, and PGE2 production in human patellar tendon fibroblasts

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Yang, Guoguang, Im, Hee-Jeong, Wang, James H.-C.·2005·Gene

DOI 10.1016/j.gene.2005.08.006PMC PMC2901527

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Abstract

While mechanical loading is known to be essential in maintaining tendon homeostasis, repetitive mechanical loading has also been implicated in the etiology of tendon overuse injuries. The purpose of this study was to determine whether cyclic mechanical stretching regulates inflammatory responses induced by interleukin-1beta (IL-1beta) treatment in human patellar tendon fibroblasts (HPTFs). HPTFs were grown in microgrooved silicone dishes, where they became elongated in shape and aligned with the microgrooves, which is similar to the shape and organization of tendon fibroblasts in vivo. Cyclic uniaxial stretching was then applied to silicone culture dishes with a 4% or 8% stretch at a stretching frequency of 0.5 Hz for a duration of 4 h in the presence or absence of 10 pM IL-1beta treatment. Non-stretched cells in the presence or absence of IL-1beta were used for controls, respectively. The expression of cyclooxygenase-2 (COX-2), matrix metalloproteinase-1 (MMP-1), and the production of prostaglandin E2 (PGE2) were measured. In the absence of stretching, it was found that 10 pM of IL-1beta markedly induced higher levels of COX-2, MMP-1 gene expression, and PGE2 production than non-treated cells. Furthermore, cells with 4% stretching decreased the COX-2 and MMP-1 gene expression and PGE2 production that were stimulated by IL-1beta, whereas cells with 8% stretching further increased these gene products and/or expression levels in addition to the effects of IL-1beta stimulation. Thus, the results suggest that repetitive, small-magnitude stretching is anti-inflammatory, whereas large-magnitude stretching is pro-inflammatory. Therefore, moderate exercise may be beneficial to reducing tendon inflammation.

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Authors: Yang, G., Im, H.-J., & Wang, J. H.-C.
Affiliations: University of Pittsburgh (US)
Rush University Medical Center (US)
Corresponding author: Wang, James H.-C.
ORCID: Im, Hee-Jeong
Wang, James H.-C.
Venue: Gene
Publisher: Elsevier BV
Published: 2005-12
Volume: 363
Pages: 166-172
ISSN: 0378-1119 (ISSN-L)
DOI: 10.1016/j.gene.2005.08.006
PMC: PMC2901527
OpenAlex: W2082252073
Cited by: 282
References: 36
Citations by year: 2026: 11 · 2025: 9 · 2024: 5 · 2023: 12 · 2022: 15 · 2021: 10 · 2020: 19 · 2019: 17 · 2018: 13 · 2017: 15 · 2016: 14 · 2015: 20 · 2014: 13 · 2013: 13 · 2012: 22
FWCI: 8.09
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gene (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Veterans Affairs (I01BX002647)
U.S. Public Health Service (049921)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR053220)
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Keywords: IL-1β, cyclooxygenase-2, MMP-1, prostaglandin E2, tendon inflammation, tendon homeostasis, anti-inflammatory effects of exercise
MeSH terms: Adolescent, Adult, Base Sequence, Fibroblasts, Humans, Interleukin-1, Male, Patella, Physical Stimulation, Tendons, Dinoprostone, DNA Primers, Reverse Transcriptase Polymerase Chain Reaction, Matrix Metalloproteinase 1, Cyclooxygenase 2

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Repetitive mechanical stretching modulates IL-1β induced COX-2, MMP-1 expression, and PGE2 production in human patellar tendon fibroblasts

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