The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke
Open accessAbstract
Epigenetic alterations may mechanistically explain the developmental origins of adult disease, namely the hypothesis that many complex adult chronic diseases originate as a result of conditions encountered in utero. If true, epigenetically regulated imprinted genes, critical to normal growth and development, may partially mediate these outcomes. We determine the influence of in utero exposure to cigarette smoking on methylation at two differentially methylated regions (DMRs) regulating Insulin-like Growth Factor 2 (IGF2) and H19, and how this might relate to birth weight of infants born to 418 pregnant women. Smoking status was ascertained through self-report and medical records. Bisulfite pyrosequencing was used to measure methylation in umbilical cord blood DNAs. Least squares DNA methylation means at each DMR and birth weight were compared between infants of smokers and non-smokers, using generalized linear models. While there were no significant differences at the H19 DMR, infants born to smokers had higher methylation at the IGF2 DMR than those born to never smokers or those who quit during pregnancy (49.5%, SD=8.0 versus 46.6%, SD=5.6 and 45.8%, SD=6.3, respectively; p=0.0002). The smoking-related increase in methylation was most pronounced in male offspring (p for sex interaction=0.03), for whom approximately 20% of smoking-related low birth weight was mediated by DNA methylation at the IGF2 DMR. Our findings suggest that IGF2 DMR plasticity is an important mechanism by which in utero adjustments to environmental toxicants are conferred. Larger studies to replicate these findings are required.
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Cites
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531
The fetal and infant origins of adult disease.
Barker, D. J. (1990) · BMJ · doi:10.1136/bmj.301.6761.1111 · Cited by 2,768
Environmental epigenomics and disease susceptibility
Jirtle, R. L., & Skinner, M. K. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2045 · Cited by 2,492
Self-citationInsulin and insulin-like growth factor signalling in neoplasia
Pollak, M. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2536 · Cited by 2,059
The Developmental Origins of Adult Disease
Barker, D. J. P. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719428 · Cited by 1,854
Obesity in Young Men after Famine Exposure in Utero and Early Infancy
Ravelli, G.-P., Stein, Z. A., & Susser, M. W. (1976) · New England Journal of Medicine · doi:10.1056/nejm197608122950701 · Cited by 1,647
Dolinoy, D. C., Huang, D., & Jirtle, R. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703739104 · Cited by 1,369 · cited 2×
“Methylation differences observed in this study are small when compared to those found in studies of animal exposure (Dolinoy et al., 2007) or in human pathology (Cui, 2007; Ito et al.”
Self-citationGluckman, P. D., Hanson, M. A., & Beedle, A. S. (2007) · American Journal of Human Biology · doi:10.1002/ajhb.20590 · Cited by 1,006
Heijmans, B. T., Kremer, D., Tobi, E. W., Boomsma, D. I., & Slagboom, P. E. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm010 · Cited by 238 · cited 2×
“Major strengths of our study include the large sample size and the use of quantitative methods of analysis for DNA methylation (Heijmans et al., 2007).”
Cited by
Joubert, B. R., Håberg, S. E., Nilsen, R. M., Wang, X., Vollset, S. E., Murphy, S. K., Huang, Z., Hoyo, C., Midttun, Ø., Cupul-Uicab, L. A., et al. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1205412 · Cited by 716
Self-citationRichmond, R. C., Simpkin, A. J., Woodward, G., Gaunt, T. R., Lyttleton, O., McArdle, W. L., Ring, S. M., Smith, A. D. A. C., Timpson, N. J., Tilling, K., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddu739 · Cited by 372
Newborns of obese parents have altered DNA methylation patterns at imprinted genes
Soubry, A., Murphy, S. K., Wang, F., Huang, Z., Vidal, A. C., Fuemmeler, B. F., Kurtzberg, J., Murtha, A., Jirtle, R. L., Schildkraut, J. M., et al. (2015) · International Journal of Obesity · doi:10.1038/ijo.2013.193 · Cited by 326
Self-citationCortessis, V. K., Thomas, D. C., Levine, A. J., Breton, C. V., Mack, T. M., Siegmund, K. D., Haile, R. W., & Laird, P. W. (2012) · Human Genetics · doi:10.1007/s00439-012-1189-8 · Cited by 319
Influence of environmental exposure on human epigenetic regulation
Marsit, C. J. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.106971 · Cited by 253
Metadata
- Authors
- Murphy, S. K., Adigun, A., Huang, Z., Overcash, F., Wang, F., Jirtle, R. L., Schildkraut, J. M., Murtha, A. P., Iversen, E. S., & Hoyo, C.
- Venue
- Gene
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 494
- Issue
- 1
- Pages
- 36-43
- ISSN
- 0378-1119 (ISSN-L)
- OpenAlex
- W2003006766
- Cited by
- 227
- References
- 9
- FWCI
- 11.15
- Type
- journal article
- Language
- en
- Open access
- green
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