Combination with TMZ and miR-505 inhibits the development of glioblastoma by regulating the WNT7B/Wnt/β-catenin signaling pathway
Abstract
TMZ is the only drug that has improved survival of GBM patients although minimally. However, a number of GBM patients did not respond to TMZ-based chemotherapy. Here, we found that miR-505 inhibited tumorigenesis as a tumor suppressor in glioblastoma. In addition, TMZ could increase the levels of miR-505 and combination with pri-miR-505 and TMZ promoted the suppressive role mediated by miR-505 in GBM cells. Furthermore, miR-505 inactivated the Wnt/β-catenin signaling pathway by directly targeting and inhibiting WNT7B. In conclusion, our results demonstrated that the induction of miR-505 in combination with TMZ treatment could be a useful therapeutic strategy for suppressing GBM.
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Reduced expression of miR-505-3p enhances tumorigenic properties, including cell proliferation, colony formation, cell cycle progression, tumor cell migration, metastasis, and tumor growth in vivo.
“Reduced expression of miR-505-3p enhances tumorigenic properties, including cell proliferation, colony formation, cell cycle progression, tumor cell migration, metastasis, and tumor growth in vivo (19)(20)(21).”
From Functional interaction between miR-505-3p and miR-21 contributes to GBM suppression (2026) · cites this paper as [21]
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Functional interaction between miR-505-3p and miR-21 contributes to GBM suppression
Banadkooki, M. Z., Soltani, B. M., & Mowla, S. J. (2026) · Scientific Reports · doi:10.1038/s41598-026-59926-5
“Reduced expression of miR-505-3p enhances tumorigenic properties, including cell proliferation, colony formation, cell cycle progression, tumor cell migration, metastasis, and tumor growth in vivo 19–21 .”
- Authors
- Zhang, C., Yang, X., Fu, C., & Liu, X.
- Affiliations
- Affiliated Hospital of Jining Medical University (CN)
- Corresponding author
- Liu, Xin
- Venue
- Gene
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 672
- Pages
- 172-179
- ISSN
- 0378-1119 (ISSN-L)
- OpenAlex
- W2807711431
- Cited by
- 30
- References
- 0
- Citations by year
- 2024: 7 · 2023: 1 · 2022: 2 · 2021: 7 · 2020: 6 · 2019: 7
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- glioblastoma, temozolomide, miR-505, Wnt7b, Wnt/β-catenin signaling, microRNA, tumor suppressor, combination therapy, drug resistance
- MeSH terms
- Temozolomide, Animals, Base Sequence, Binding Sites, Brain Neoplasms, Combined Modality Therapy, Dacarbazine, Glioblastoma, Humans, Mice, Nude, Gene Expression, Gene Expression Regulation, Neoplastic, Antineoplastic Agents, Alkylating, Xenograft Model Antitumor Assays, RNA Interference, MicroRNAs, Cell Line, Tumor, Wnt Proteins, beta Catenin, Wnt Signaling Pathway, Carcinogenesis
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