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WIP/ITSN1 complex is involved in cellular vesicle trafficking and formation of filopodia-like protrusions
Abstract
WIP (WASP interacting protein) together with N-WASP (neural Wiskott-Aldrich syndrome protein) regulates actin polymerization that is crucial for invadopodia and filopodia formation. Recently, we reported the WIP interaction with ITSN1 which is highly implicated in endo-/exocytosis, apoptosis, mitogenic signaling and cytoskeleton rearrangements. Here we demonstrate that the WIP/ITSN1 complex is involved in the transferrin receptor recycling and partially co-localizes with a marker of the fast recycling endosomes, RAB4. Moreover, ITSN1 recruits WIP to RAB4-positive vesicles upon overexpression. Our data indicate that WIP enhances the interaction of N-WASP with ITSN1 and promotes ITSN1/β-actin association. Moreover, the WIP/ITSN1-L complex facilitates formation of filopodia-like protrusions in MCF-7 cells. Thus, WIP/ITSN1 complex is involved in the cellular vesicle trafficking and actin-dependent membrane processes.
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Several genes were assigned to clusters enriched for gene sets consistent with their known functions, including KDM1B, BRSK2, and ITSN1, consistent with published functional evidence.
“Several genes were assigned to clusters that showed enrichment for gene sets consistent with their known functions, including KDM1B,41 BRSK2,42 and ITSN143 consistent with published functional evidence”
From Exome sequencing of 457 autism families recruited online provides evidence for autism risk genes (2019) · cites this paper as [43]
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References 52 · Cited by 18
Metadata
- Authors
- Gryaznova, T., Gubar, O., Burdyniuk, M., Kropyvko, S., & Rynditch, A.
- Affiliations
- Institute of Molecular Biology and Genetics (UA)
- Corresponding author
- Gryaznova, Tetyana
- Venue
- Gene
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 674
- Pages
- 49-56
- ISSN
- 0378-1119 (ISSN-L)
- OpenAlex
- W2811498266
- Cited by
- 18
- References
- 52
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 3
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gene (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NAS (0115U002947)
- National Center for Scientific Research (0113U002831)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- WIP, ITSN1, N-WASP, actin polymerization, vesicle trafficking, filopodia formation, transferrin receptor recycling, Rab4, beta-actin, MCF-7 cells, endocytosis, exocytosis
- MeSH terms
- Actins, Biological Transport, Cytoskeletal Proteins, Humans, Pseudopodia, Endosomes, Transferrin, rab4 GTP-Binding Proteins, Cytoplasmic Vesicles, Adaptor Proteins, Vesicular Transport, Intracellular Signaling Peptides and Proteins, Wiskott-Aldrich Syndrome Protein, Neuronal, HEK293 Cells, MCF-7 Cells
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